DUSP4 mitigates doxorubicin-induced cardiotoxicity via the p38 MAPK/MK2 signaling pathway [0.03%]
DUSP4通过p38 MAPK/MK2信号通路缓解多柔比星诱导的心脏毒性
Lijie Deng,Yafang Zha,Chaoying Zhu et al.
Lijie Deng et al.
Doxorubicin (DOX) is a potent chemotherapeutic agent widely used to treat various malignancies; however, its dose-dependent cardiotoxicity severely limits long-term clinical application. Loss of Dual Specificity Phosphatase 4 (DUSP4) has be...
Signal peptide-directed proteins generated in the endoplasmic reticulum are secreted or degraded via the autophagic pathway [0.03%]
内质网合成的信号肽导向性蛋白质通过自噬途径被分泌或降解
Taek-Yeong Kim,Ye-Jin Cho,Kwon-Yul Ryu
Taek-Yeong Kim
Signal peptides (SPs) are short N-terminal sequences that direct proteins to the endoplasmic reticulum (ER). After cleavage of the SP, these proteins are mostly trafficked to the Golgi apparatus for secretion. Lipocalin-2 (LCN2), a neurotox...
ADAM proteases in cytokine biology: Modulators of immune signaling, inflammation and cancer [0.03%]
细胞因子生物学中的ADAM蛋白酶家族：免疫信号、炎症和癌症的调节者
Heba Khattab,Jelena Solujic,Mohamed I Saad
Heba Khattab
Ectodomain shedding, a post-translational process mediated primarily by A Disintegrin And Metalloprotease (ADAM) family members, represents a fundamental mechanism regulating intercellular communications. By cleaving the extracellular domai...
Corrigendum to "Frequent EPHA2 receptor mutations in cholangiocarcinoma disrupt receptor forward signaling supporting a tumor suppressor role" [BBA Mol. Cell Res. 1873 (2026) 120081] [0.03%]
“EPHA2受体在胆管癌中频繁突变，破坏受体正向信号转导，支持其肿瘤抑制作用[BBA Mol. Cell Res. 1873 (2026) 120081]”一文的勘误通知
Evodie Koutouan,Alejandro Lillo,Ayano Kabashima et al.
Evodie Koutouan et al.
Polyphosphate metabolism: Enzymatic pathways and regulation [0.03%]
聚磷酸盐代谢： enzymatic pathways and regulation酶促途径和调控
Sarah Krukenberg,Giuliano A Kullik,Thomas Renné
Sarah Krukenberg
Polyphosphate (polyP) is an ancient, evolutionarily conserved inorganic polymer found in all domains of life. PolyP functions in energy storage, metal chelation, phosphate buffering, and regulation of fundamental physiological processes suc...
The role of IL-6 in rheumatoid arthritis comorbidity and implications for therapy [0.03%]
白细胞介素6在类风湿关节炎共病中的作用及对治疗的启示
Federica Monaco,Sandra Dimonte,Simon A Jones
Federica Monaco
Immune-mediated inflammatory diseases (IMIDs) are complex conditions commonly associated with alterations in cytokine biology. In rheumatoid arthritis (RA), the systemic activities of cytokines, such as interleukin (IL)-6, have led to the c...
LncRNA PVT1 activates HIF-1α/RANKL signal to promote osteoclast differentiation and inflammatory response through post-transcriptional regulation [0.03%]
长链非编码RNA PVT1通过转录后调控激活HIF-1α/RANKL信号促进破骨细胞分化和炎症反应
Siyu Lu,Muguo Song,Lirong Ren et al.
Siyu Lu et al.
Osteoclasts play an essential role as the main functional cells for bone resorption in osteomyelitis (OM). Staphylococcus aureus (SA), a prevalent pathogen causing bone infections, significantly contributes to OM by synthesizing substantial...
S5D mutation of NLRP3 revealed its role in NLRP3 inflammasome complex using split-luciferase complementation assay [0.03%]
NLRP3的S5D突变通过分裂型萤光素酶补救实验揭示其在NLRP3炎性小体复合物中的作用
Mojdeh Amandadi,Hadi Ravan,Mohammad Hashemabadi et al.
Mojdeh Amandadi et al.
The NOD-like receptor (NLR) family pyrin domain-containing protein 3 (NLRP3) is a critical cytosolic inflammasome sensor of exogenous and endogenous danger signals and is a highly attractive medicinal target against inflammatory diseases. T...
Adhesion GPCR ADGRL1/Latrophilin-1 mobilizes β-arrestins as a prerequisite for endosomal restriction of G protein activation and splice-dependent scaffolds [0.03%]
粘附GPCR ADGRL1 / Latrophilin-1 摆动β-逮捕蛋白作为囊泡限制G蛋白激活和剪接依赖性支架的先决条件
Sheila Ribalta-Mena,Ana Lilia Moreno-Salinas,Judith Hernández-Aranda et al.
Sheila Ribalta-Mena et al.
Sustained signaling mediated by β-arrestins (βarr) in endosomal compartments has been described for several classical G protein-coupled receptors (GPCR), yet whether adhesion GPCRs-many of which exhibit constitutive activity driven by int...
Endoplasmic reticulum stress-mediated epithelial-mesenchymal transition contributes to cardiac biomarker-induced kidney injury [0.03%]
内质网应激介导的上皮间质转化加重心脏生物标志物所致肾损伤
Mengyuan Cheng,Xiaoyu Zhang,Ye Shi et al.
Mengyuan Cheng et al.
Renal dysfunction is a frequent comorbidity in heart failure (HF) patients, independently linked to poor prognosis. However, the intricate pathogenesis of the complex interaction between the heart and kidney remains unclear. This study anal...