Sensing the needs: Molecular basis of miRNA regulatory role of ELAVL protein HuR [0.03%]
感应需求：ELAVL蛋白HuR调控作用的miRNA分子基础
Kamalika Mukherjee
Kamalika Mukherjee
Regulation of miRNAs in mammalian cells-including their expression, activity, transport, storage, and export-is vital for the control of gene expression and cellular function. This process is affected by external stimuli, such as stress or ...
IL-6 family cytokines behind acute COVID-19 and Long COVID syndrome: Mechanisms, biomarkers, and intervention strategies [0.03%]
急性COVID-19和长新冠综合征背后的IL-6家族细胞因子：机制、生物标志物和干预策略
Matilde Bustos,María Ángeles Rodríguez-Hernández
Matilde Bustos
IL-6 family of cytokines is increasingly recognized as a potential contributor to the immune alterations observed in COVID-19 and its long-term sequelae. Beyond the well-established pro-inflammatory actions of IL-6 itself, members of this f...
RSL1D1 deficiency reduces FTH1 stability and induces ferroptosis and senescence in retinal pigment epithelial cells in diabetic retinopathy [0.03%]
RSL1D1缺乏通过降低FTH1稳定性诱导糖尿病视网膜病变中色素上皮细胞的铁死亡和衰老现象
Leilei Qin,Yanli Guo,Yi Zhang et al.
Leilei Qin et al.
Ribosomal L1 domain-containing protein 1 (RSL1D1) is an RNA-binding protein that relates to senescence. Nevertheless, the mechanism of RSL1D1 in modulating senescence and ferroptosis in diabetic retinopathy (DR) remains undefined. The DR mi...
FGFR1 induces RSK-dependent non-canonical activation of EphA2 during EMT [0.03%]
在上皮间质转化过程中，FGFR1通过RSK依赖性非经典途径活化EphA2
Yue Zhou,Leixin Song,Tomohiro Yamamura et al.
Yue Zhou et al.
Epithelial-to-mesenchymal transition (EMT) plays crucial roles in tumor progression, including cancer cell migration. Non-canonical phosphorylation of the receptor tyrosine kinase EphA2 at Ser-897 via the ERK-RSK pathway also induces cancer...
Orchestration of OXPHOS biogenesis through regulation of mitochondrial translation [0.03%]
通过调节线粒体翻译调控氧化磷酸化生物发生成组装
Andreas Carlström,Carmela Vazquez-Calvo,Martin Ott
Andreas Carlström
Mitochondrial gene expression is a remnant of the endosymbiotic origin of the organelle, which contains a complete gene expression system that contributes only a handful of subunits to the complexes driving oxidative phosphorylation (OXPHOS...
Leucine rich repeat containing protein 8B (LRRC8B) - A novel modulator of endoplasmic reticulum (ER) stress response [0.03%]
含有亮氨酸丰富重复序列的蛋白质8B(LRRC8B)—一种新的内质网应激反应调节因子
N Raja Mathanki,Olivia Neibel Isaac Newton,Amal Kanti Bera
N Raja Mathanki
The endoplasmic reticulum (ER), a major calcium ion (Ca2+) reservoir, plays a pivotal role in lipid synthesis, protein synthesis, and secretion. Disruption of ER function leads to the accumulation of misfolded proteins, resulting in ER stre...
Metformin triggers ATF4-mediated UPRmt and COX-2 inflammation in adipocytes [0.03%]
二甲双胍通过ATF4介导的UPRmt诱导脂肪细胞中的COX-2炎症反应
Juthakorn Poothong,Chutipong Chiamkunakorn,Wichit Suthammarak et al.
Juthakorn Poothong et al.
Metformin is the most common drug for type 2 diabetes due to its action to improve insulin sensitivity and enhance glucose uptake in tissues, including adipose tissue. As a mitochondrial complex I inhibitor, treatment with metformin may cau...
AKNA drives neuroblastoma cell fate transition through chromatin modifications of stemness factors and differentiation by cytosolic retention [0.03%]
AKNA通过组蛋白修饰诱导神经母细胞瘤干细胞特性向分化状态的转变
Soumen Manna,Kirtana Rallabhandi,Tirthankar Baral et al.
Soumen Manna et al.
Neuroblast cells play a pivotal role in adult neurogenesis. However, the detailed mechanisms underlying the acquisition of pluripotency or the process of differentiation remain unknown. Herein, the role of the AT-hook protein AKNA in regula...
Identification and validation of novel small molecule inhibitors targeting FoxM1-DNA binding domain with anti-cancer potential [0.03%]
靶向FoxM1-DNA结合域的新型小分子抑制剂的鉴定与验证及其抗癌潜力评估
Pradeep Singh Cheema,Neha Jaiswal,Sanjay Kumar Dey et al.
Pradeep Singh Cheema et al.
The Forkhead box M1 (FoxM1) transcription factor is a well-established oncogenic driver, with its overexpression closely associated with tumor grade, aggressiveness and adverse clinico-pathological features across multiple cancer types. Thi...
Inhibition of PrimPol by mevalonate pyrophosphate: A metabolic link between genome integrity and cytokinesis? [0.03%]
牻牛儿磷酸抑制PrimPol：基因组完整性和细胞分裂之间的一种代谢联系？
Miguel A Lasunción,Diego Gómez-Coronado,Gema de la Peña et al.
Miguel A Lasunción et al.
Cholesterol and certain precursors are essential for cell division, which is consistent with the activation of cholesterol biosynthesis in preparation for cell proliferation. Inhibition of diphosphomevalonate decarboxylase by fluoromevalona...