Identification and characterization of a novel Plakoglobin-binding protein highly expressed in the testes [0.03%]
鉴定并表征一种新的粘附连接蛋白plakoglobin结合蛋白并在睾丸中高表达
Miyu Yamashita,Kotone Teshima,Mizuki Higuchi et al.
Miyu Yamashita et al.
1700020L24Rik was originally identified as one of the numerous mouse genes transcriptionally regulated by MEIOSIN (Meiosis initiator), but the function of its gene product has remained unknown. The human homolog of 1700020L24Rik is C17orf50...
Folding the message: mRNA structure as a regulatory layer of human mitochondrial gene expression [0.03%]
折叠的信息：mRNA结构作为人类线粒体基因表达的调控层
Ahram Ahn,Seungwoo Hong,Michele Brischigliaro et al.
Ahram Ahn et al.
Mammalian mitochondrial gene expression operates within an unusually compact genomic architecture in which most regulatory information must be encoded within or immediately adjacent to protein-coding sequences. In this context, mitochondria...
Engrailed, a target of the miR-92 family, attenuates Tau accumulation and associated memory deficits in Drosophila [0.03%]
engrailed通过miR-92家族抑制Tau累积及其相关记忆缺陷在果蝇中的作用研究
Minh Nguyet Nguyen,Tae Hoon Ryu,Jeong-Soo Lee et al.
Minh Nguyet Nguyen et al.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the pathological accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles composed of hyperphosphorylated Tau protein. While microRNAs (miRNAs...
MEF2A/KMT2D/H3K4me3/LOX axis promotes osteoclast differentiation by increasing autophagic flux and participates in LPS-induced osteolysis [0.03%]
MEF2A/KMT2D/H3K4me3/LOX轴通过增加自噬流促进破骨细胞分化并参与LPS诱导的骨质溶解
Kaihang Lu,Hui Han,Zhenyu Li et al.
Kaihang Lu et al.
Overactivation of osteoclasts represents the core pathological mechanism driving bone destruction and pathological osteolysis, yet safe and effective targeted therapeutic strategies remain lacking in clinical settings. Lysyl oxidase (LOX), ...
Cyclase-associated protein 1 facilitates actin-dependent mitochondrial fission in podocytes associated with diabetic nephropathy [0.03%]
cyclase相关蛋白1通过促进系膜细胞线粒体裂变介导糖尿病肾病发生发展
Huimin Ma,Shuang Yao,Zihan Wang et al.
Huimin Ma et al.
Aberrant mitochondrial dynamics in podocytes are closely associated with the progression of diabetic nephropathy (DN); however, the underlying mechanisms remain incompletely understood. Recent research has demonstrated that cyclase-associat...
DHCR7 promotes granulosa cells ferroptosis and represents a potential therapeutic target in premature ovarian insufficiency [0.03%]
DHCR7促进颗粒细胞铁死亡并可作为早发性卵巢功能不全的潜在治疗靶点
Xingyu Huo,Yueming Wang,Zheyang Wang et al.
Xingyu Huo et al.
Premature Ovarian Insufficiency (POI) is characterized by declining ovarian function before the age of 40, which affects female fertility. Granulosa cells (GCs) are essential for follicular development and ovarian function, and their dysfun...
RREB1-driven FMR1 upregulation promotes colorectal cancer angiogenesis via VEGFA-mediated MAPK/PI3K signaling activation [0.03%]
RREB1驱动的FMR1上调通过VEGFA介导的MAPK/PI3K信号激活促进结直肠癌血管生成
Yuhan Hu,Pei Yu,Zhaoxiang Yan et al.
Yuhan Hu et al.
Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, and angiogenesis is a critical driver of tumor growth and metastasis. In this study, we found that FMR1, an RNA-binding protein, was markedly upregulated...
TMEM132A affects proliferation, invasion, and apoptosis via the β-catenin-dependent Wnt signaling in breast cancer [0.03%]
TMEM132A通过β-连环蛋白依赖型Wnt信号影响乳腺癌的增殖、侵袭和凋亡
Xiaoqiang Liu,Linmiao Qin,Huawei Yang
Xiaoqiang Liu
Breast cancer continues to pose a significant health threat to women globally, highlighting the urgent need for novel therapeutic targets. The Wnt/β-catenin pathway plays an important role in tissue homeostasis. The Wnt/β-catenin signalin...
The yin and yang interplay between HDAC6 and KDM1 regulates the lysosomal degradation of mutp53 in colon cancer cells undergoing TG-induced ER stress [0.03%]
HDAC6和KDM1之间的阴阳互作通过溶酶体途径降解结肠癌细胞中TG诱导的内质网应激相关的mutp53蛋白质
Rossella Benedetti,Rosanna Paola Amato,Michele Di Crosta et al.
Rossella Benedetti et al.
Post-translational modifications (PTMs) play a key role in regulating protein/protein interactions and protein stability, thus influencing protein expression and function. HSPs and p53, including its wtp53 and mutp53 forms, make no exceptio...
N-glycome composition of extracellular vesicles released by urological cancer cells and reference non-malignant cells [0.03%]
泌尿系统癌细胞和参考良性细胞释放的细胞外囊泡的N-糖组组成
Magdalena Surman,Sara Trzos,Magdalena Wilczak et al.
Magdalena Surman et al.
Transport of bioactive molecules via extracellular vesicles (EVs) is one of the mechanisms of intercellular communication. EVs regulate a number of physiological processes in recipient cells, but also contribute to development and progressi...