Yuan Li,Ling Wang,Xiaofeng Liu et al.
Yuan Li et al.
NIR, a novel INHAT, negatively regulates the transcription activity of tumor repressor p53. However, if NIR functions in the tumorigenesis dependent on the regulation of p53 remains unknown. Here, we report that NIR promotes progression of ...
Kisspeptin preserves mitochondrial function by inducing mitophagy and autophagy in aging rat brain hippocampus and human neuronal cell line [0.03%]
Kisspeptin通过诱导衰老大鼠脑海马和人神经元细胞系的线粒体自噬和自噬来维持线粒体功能
Ushodaya Mattam,Noble Kumar Talari,Arun Kumar Paripati et al.
Ushodaya Mattam et al.
It has become amply clear that mitochondrial function defined by quality, quantity, dynamics, homeostasis, and regulated by mitophagy and mitochondrial biogenesis is a critical metric of human aging and disease. As a consequence, therapeuti...
Altered mitochondrial fusion drives defensive glutathione synthesis in cells able to switch to glycolytic ATP production [0.03%]
改变的线粒体融合驱动细胞合成防御性谷胱甘肽
David A Patten,Shawn McGuirk,Ujval Anilkumar et al.
David A Patten et al.
Mitochondria are highly dynamic organelles. Alterations in mitochondrial dynamics are causal or are linked to numerous neurodegenerative, neuromuscular, and metabolic diseases. It is generally thought that cells with altered mitochondrial s...
Suppressed nuclear envelope proteins activate autophagy of vascular smooth muscle cells during cyclic stretch application [0.03%]
周期拉伸过程中核膜蛋白激活血管平滑肌细胞自噬机制的研究
Hai-Peng Li,Ji-Ting Liu,Yuan-Xiu Chen et al.
Hai-Peng Li et al.
Dysfunctions of vascular smooth muscle cells (VSMCs) play crucial roles in vascular remodeling in hypertension, which correlates with pathologically elevated cyclic stretch due to increased arterial pressure. Recent researches reported that...
Lysophosphatidic acid receptor 5 transactivation of TGFBR1 stimulates the mRNA expression of proteoglycan synthesizing genes XYLT1 and CHST3 [0.03%]
溶血磷脂酸受体5转激活TGFBR1刺激蛋白多糖合成基因XYLT1和CHST3的mRNA表达
Ying Zhou,Peter J Little,Yingnan Cao et al.
Ying Zhou et al.
Lysophosphatidic acid (LPA) via transactivation dependent signalling pathways contributes to a plethora of physiological and pathophysiological responses. In the vasculature, hyperelongation of glycosaminoglycan (GAG) chains on proteoglycan...
Atorvastatin prevents hearing impairment in the presence of hyperlipidemia [0.03%]
阿托伐他汀可预防高脂血症引起的听力损伤
Yun Yeong Lee,Oak-Sung Choo,Yeon Ju Kim et al.
Yun Yeong Lee et al.
It is known that hyperlipidemia is a risk factor for sensorineural hearing loss. However, the biological mechanisms underlying hyperlipidemia and hearing impairment have not been completely elucidated in the cochlea. Based on our previous s...
Connexin 32 induces pro-tumorigenic features in MCF10A normal breast cells and MDA-MB-231 metastatic breast cancer cells [0.03%]
连接蛋白32在MCF10A正常乳腺细胞和MDA-MB-231转移性乳腺癌细胞中诱导促瘤特征
Asli Adak,Yagmur Ceren Unal,Simge Yucel et al.
Asli Adak et al.
Connexins (Cx), the basic subunit of gap junctions, play important roles in cell homeostasis, and their abnormal expression and function are associated with human hereditary diseases and cancers. In tumorigenesis, connexins were observed to...
Barbadin selectively modulates FPR2-mediated neutrophil functions independent of receptor endocytosis [0.03%]
巴巴定通过独立于受体胞吞作用的选择性调节FPR2介导的中性粒细胞功能
Martina Sundqvist,André Holdfeldt,Shane C Wright et al.
Martina Sundqvist et al.
FPR2, a member of the family of G protein-coupled receptors (GPCRs), mediates neutrophil migration, a response that has been linked to β-arrestin recruitment. β-Arrestin regulates GPCR endocytosis and can also elicit non-canonical recepto...
Acute depletion of telomerase components DKC1 and NOP10 induces oxidative stress and disrupts ribosomal biogenesis via NPM1 and activation of the P53 pathway [0.03%]
端粒酶成分DKC1和NOP10的急性耗竭通过NPM1和P53通路的激活诱导氧化应激并破坏核糖体生物的发生
José Santiago Ibáñez-Cabellos,Marta Seco-Cervera,Carmen Picher-Latorre et al.
José Santiago Ibáñez-Cabellos et al.
Mutations in DKC1, NOP10, and TINF2 genes, coding for proteins in telomerase and shelterin complexes, are responsible for diverse diseases known as telomeropathies and ribosomopathies, including dyskeratosis congenita (DC, ORPHA 1775). Thes...
Iron-sulfur cluster biogenesis, trafficking, and signaling: Roles for CGFS glutaredoxins and BolA proteins [0.03%]
铁硫簇生物合成，转运和信号转导：CGFS谷氧还蛋白和BolA蛋白的作用
Evan A Talib,Caryn E Outten
Evan A Talib
The synthesis and trafficking of iron-sulfur (Fe-S) clusters in both prokaryotes and eukaryotes requires coordination within an expanding network of proteins that function in the cytosol, nucleus, mitochondria, and chloroplasts in order to ...