One ring to bring them all and in the darkness bind them: The trafficking of heme without deliverers [0.03%]
一枚戒指向黑暗中召集并统御他们：没有运载蛋白的血红素运输
Ian G Chambers,Mathilda M Willoughby,Iqbal Hamza et al.
Ian G Chambers et al.
Heme, as a hydrophobic iron-containing organic ring, is lipid soluble and can interact with biological membranes. The very same properties of heme that nature exploits to support life also renders heme potentially cytotoxic. In order to uti...
Adventures with Mike [0.03%]
与迈克的冒险经历
Robin Irvine
Robin Irvine
Here are a few personal recollections of my 'big adventure' with Mike. Keywords: Calcium; IP3; Inositol. ...
Simon J Mayr,Ralf-R Mendel,Guenter Schwarz
Simon J Mayr
The molybdenum cofactor (Moco) represents an ancient metal‑sulfur cofactor, which participates as catalyst in carbon, nitrogen and sulfur cycles, both on individual and global scale. Given the diversity of biological processes dependent on...
Brian J Earley,Adelita D Mendoza,Chieh-Hsiang Tan et al.
Brian J Earley et al.
C. elegans is a powerful model for studies of zinc biology. Here we review recent discoveries and emphasize the advantages of this model organism. Methods for manipulating and measuring zinc levels have been developed in or adapted to the w...
m6A-YTHDF1-mediated TRIM29 upregulation facilitates the stem cell-like phenotype of cisplatin-resistant ovarian cancer cells [0.03%]
m6A-YTHDF1介导的TRIM29上调促进了顺铂耐药卵巢癌细胞干性特性维持
Liang Hao,Jia-Mei Wang,Bao-Qin Liu et al.
Liang Hao et al.
Ovarian cancer is the deadliest gynaecologic malignancy, and the five-year survival rate of patients is less than 35% worldwide. Cancer stem cells (CSCs) are a population of cells with stem-like characteristics that are thought to cause che...
Rab5b function is essential to acquire heme from hemoglobin endocytosis for survival of Leishmania [0.03%]
获取血红素以保证利什曼原虫生存必需Rab5b功能通过内吞血红蛋白获得血红素
Ruchir Rastogi,Anjali Kapoor,Jitender Kumar Verma et al.
Ruchir Rastogi et al.
Previously, we showed that Rab5a and Rab5b differentially regulate fluid-phase and receptor-mediated endocytosis in Leishmania, respectively. To unequivocally demonstrate the role of Rab5b in hemoglobin endocytosis in Leishmania, we generat...
Loss of keratinocyte Mcpip1 abruptly activates the IL-23/Th17 and Stat3 pathways in skin inflammation [0.03%]
角质细胞中Mcpip1的丢失会突然激活皮肤炎症中的IL-23 / Th17和Stat3通路
Agata Lichawska-Cieslar,Piotr Konieczny,Weronika Szukala et al.
Agata Lichawska-Cieslar et al.
Sarah Hofmann,Nancy Kedersha,Paul Anderson et al.
Sarah Hofmann et al.
Stress granules (SGs) are membrane-less ribonucleoprotein (RNP)-based cellular compartments that form in the cytoplasm of a cell upon exposure to various environmental stressors. SGs contain a large set of proteins, as well as mRNAs that ha...
FGFR1 overexpression renders breast cancer cells resistant to metformin through activation of IRS1/ERK signaling [0.03%]
FGFR1过表达通过激活IRS1 / ERK信号使乳腺癌细胞对二甲双胍产生抗性
Yujie Shi,Zhikun Ma,Qiong Cheng et al.
Yujie Shi et al.
Metformin has been suggested as an anti-cancer agent. However, increasing reports show that some tumors are resistant to metformin. Identification of factors affecting metformin mediated cancer therapy is of great significance. FGFR1 is a r...
Joseph J Braymer,Sven A Freibert,Magdalena Rakwalska-Bange et al.
Joseph J Braymer et al.
Iron-sulfur (Fe/S) proteins are present in virtually all living organisms and are involved in numerous cellular processes such as respiration, photosynthesis, metabolic reactions, nitrogen fixation, radical biochemistry, protein synthesis, ...