Assessing the involvement of tumor-secreted factors in the inhibition of muscle differentiation [0.03%]
评估肿瘤分泌因子在抑制肌肉分化中的作用
Miranda van der Ende,Xiaolin Li,Mieke Poland et al.
Miranda van der Ende et al.
Cancer cachexia is a multifactorial syndrome characterized by involuntary and pathological weight loss, predominantly caused by muscle wasting. While tumors can elicit detrimental effects on skeletal muscle function, the contribution of spe...
SPRED2 controls the severity of cisplatin-induced acute kidney injury by inhibiting ERK activation and TNFα production in mice [0.03%]
SPRED2通过在小鼠中抑制ERK活化和TNFα产生来控制顺铂引起的急性肾损伤的严重程度
Xu Yang,Jiali He,Tong Gao et al.
Xu Yang et al.
Cisplatin is an effective chemotherapeutic agent used to treat solid tumors, but its clinical use is limited by acute kidney injury (AKI), in which ERK signaling plays a crucial role. Here, we investigated whether Sprouty-related EVH1 domai...
Structural diversity of full-length human αvβ3 integrin revealed by cryo-EM [0.03%]
人类全长αvβ3整合素的结构多样性由cryo-EM揭示
Cang Wu,Yuanzhu Gao,Weiyan Wang et al.
Cang Wu et al.
Integrins are essential transmembrane receptors that orchestrate cell adhesion, migration, and survival, and have emerged as promising therapeutic targets for cancer, fibrosis, and autoimmune diseases. However, most integrin-targeted drugs ...
Metabolic reprogramming is implicated in the differential response of the CAL-1 plasmacytoid dendritic cell line to autophagy inhibitors [0.03%]
代谢重构参与CAL-1浆细胞样树突状细胞系对自噬抑制剂的不同反应
Carlota Ramalhinho,Paulo Antas,Philippe Pierre et al.
Carlota Ramalhinho et al.
Plasmacytoid dendritic cells (pDCs) produce large amounts of type I Interferons (IFN) and pro-inflammatory cytokines, playing crucial roles in antiviral and anticancer immunity as well as in autoimmune diseases. Understanding the mechanisms...
Transgenic overexpression of miR-486 and sAnk1.5 does not alter glucose handling in mice [0.03%]
在小鼠中过表达miR-486和sAnk1.5不影响血糖水平
S Buonocore,F Fiore,E M Rubino et al.
S Buonocore et al.
Recent studies have shown that the C allele of SNP rs508419 is associated with susceptibility to Type 2 diabetes (T2D). This SNP lies within the muscle-specific P2 promoter of human ANK1, which drives transcription of the sAnk1.5 isoform an...
Anti-tumor response by targeting glucose metabolism and depletion of membrane cholesterol in breast cancer and melanoma cells [0.03%]
通过靶向葡萄糖代谢和膜胆固醇耗竭来诱导乳腺癌和黑色素瘤细胞的抗肿瘤反应
Himanshi Yaduvanshi,Bhavana Deshmukh,Abhijeet Singh et al.
Himanshi Yaduvanshi et al.
Enhanced lactate production and cholesterol accumulation in cancer cells are often correlated with poor prognosis and the development of resistance to therapies. This study investigates a unique dual-pronged approach for abrogating tumor de...
Corrigendum to "Activation of ER stress and apoptosis by hydrogen peroxide in HeLa cells: Protective role of mild heat preconditioning at 40 °C" [Biochim. Biophys. Acta Mol. Cell Res., 1813 (2011) 1987-1999. / PMID: 21875624] [0.03%]
“H₂O₂诱导的HeLa细胞内质网应激及凋亡及其40℃预处理的热保护作用的修正”[Biochim.Biophys.Acta Mol.Cell Res., 1813 (2011) 1987-1999]校正案
Pragathi Pallepati,Diana A Averill-Bates
Pragathi Pallepati
Developmental spatiotemporal switching of the germline-specific subunits of heterodimeric NAC protein in Drosophila melanogaster [0.03%]
果蝇生殖细胞特异性异二聚体NAC蛋白亚基的时空动态转换机制研究
Elena A Mikhaleva,Natalia V Akulenko,Oxana M Olenkina et al.
Elena A Mikhaleva et al.
The ribosome-associated αβ heterodimeric ubiquitously expressed NAC protein is involved in protein homeostasis in eukaryotes. We previously reported that the germline-specific α and β subunits (gNACαβ) differ from ubiquitously express...
Escitalopram disrupts PDK1-Akt signaling in B cells through a structure-dependent mechanism independent of SERT [0.03%]
艾司西酞普兰通过独立于SERT的结构依赖性机制破坏B细胞中的PDK1-Akt信号转导路径
Yu-Lun Tseng,Meng-Ling Chiang
Yu-Lun Tseng
The PI3K-Akt pathway is a central regulator of survival and growth signals across receptor systems, controlled at the membrane-proximal PDK1-Akt signaling node. Although selective serotonin reuptake inhibitors (SSRIs) primarily target the s...
Endothelial ANGPT2 impairs cardiomyocyte calcium homeostasis via ITGB3 receptor in murine sepsis-related cardiomyopathy [0.03%]
内皮ANGPT2通过ITGB3受体损害小鼠脓毒症相关心肌病中心肌细胞的钙稳态
Yi-Ni Lu,Wen-Xue Liu,Xiao-Han Wang et al.
Yi-Ni Lu et al.
Sepsis-related cardiomyopathy (SCM) is a life-threatening complication of sepsis, characterized by cardiac dysfunction. Although angiopoietin 2 (ANGPT2) is pivotal in the pathological progress of several diseases, its functional involvement...