Cell mechanosensing at focal adhesions: Emerging insights from phase separation [0.03%]
细胞黏附斑的细胞机械感应：相分离的新见解
Jialin Xie,Ziqi Gao,Hongxiang Mei et al.
Jialin Xie et al.
Focal adhesions are central structures that allow cells to sense and respond to extracellular mechanical cues, yet traditional interaction-based models cannot fully explain their efficient protein enrichment, rapid turnover, and strong mech...
Mupirocin-mediated downregulation of claudin-14 enhances chemosensitivity in human colorectal cancer cells [0.03%]
穆匹罗芬介导的Claudin-14下调可增强人结直肠癌细胞的化疗敏感性
Yuko Mizukami,Tomoka Ando,Shiemi Tosaki et al.
Yuko Mizukami et al.
Claudin-14 (CLDN14), a tight junction protein, contributes to cell proliferation and chemoresistance in human colorectal cancer (CRC)-derived DLD-1 cells. However, small molecules targeting CLDN14 remain unexplored. Here, we identified mupi...
Focadhesin interacts with SALL4 to regulate EGFR signaling and oncogenesis in non-small cell lung cancer [0.03%]
FOCAD与SALL4互作调控非小细胞肺癌EGFR信号通路及肿瘤发生发展的新机制研究
Xin Lu,Yijie Gu,Wei Ye et al.
Xin Lu et al.
Owing to drug resistance to therapeutic targets, there is an urgent demand to find and validate new potent targets for non-small cell lung cancer (NSCLC). Although high SALL4 expression significantly promotes lung cancer growth, its oncogen...
Extracellular matrix stiffness primes the NLRP-inflammasome by promoting NLRP3 gene expression via FAK/mTOR/nuclear-actin/SREBP signalling in vascular smooth muscle cells [0.03%]
细胞外基质刚性通过FAK/mTOR/核肌动蛋白/SREBP信号促进血管平滑肌细胞中NLRP3基因表达从而启动NLRP3炎性小体反应
Lily Hadfield,Madeleine McNeill,Vealmurugan Sekar et al.
Lily Hadfield et al.
Arterial stiffening is associated with an increased risk of cardiovascular disease (CVD) morbidity and mortality. We investigated the effects of ECM-stiffness on the expression of NLRP3, a component of the NLRP3-inflammasome. VSMC interacti...
A putative role for Mrx3 and Fmp10 in regulating yeast mitochondrial acyl-CoA thioesters [0.03%]
Mrx3和Fmp10调节酵母线粒体酰基-CoA硫酯的假定作用
Marcelo Mesa Costa-Lima,Fernando Gomes,Thaynara Roberta Damaceno et al.
Marcelo Mesa Costa-Lima et al.
The hotdog-fold acyl-CoA thioesterases (ACOTs) are enzymes typically related to lipid metabolism and are widely spread across the tree of life, but many members of this group are poorly characterized. In this work, through in silico analyze...
Narirutin inhibits inflammation and oxidative stress in osteoarthritis via suppressing AKT/NF-κB signaling [0.03%]
narirutin通过抑制AKT/NF-κB信号通路抑制骨关节炎的炎症和氧化应激
Houyi Wang,Liansheng Hao,Yadong Wu et al.
Houyi Wang et al.
Narirutin is a flavanone with anti-inflammatory and antioxidant properties. The objective of this study was to evaluate its therapeutic potential against osteoarthritis. Anterior cruciate ligament transection (ACLT) rats were administered 1...
Fibroblasts carrying intermediate C9orf72 hexanucleotide repeat expansions from iNPH patients show changes in energy metabolism but no cell pathologies [0.03%]
携带中等长度C9orf72六核苷酸重复扩增的外周血成纤维细胞显示出能量代谢改变但无细胞病理表型（来自iNPH患者）
Dorit Hoffmann,Ville Korhonen,Hannah Rostalski et al.
Dorit Hoffmann et al.
Long C9orf72 hexanucleotide repeat expansions (C9-HRE) are the most common genetic cause of frontotemporal dementia (FTD), a group of neurodegenerative syndromes leading to cognitive dysfunction and frontal and temporal atrophy. FTD is a po...
SMN haploinsufficiency exacerbates high glucose dialysate-induced peritoneal inflammation and fibrosis via mTOR/NFκB signaling pathway [0.03%]
SMN单倍体不足通过mTOR/NFκB信号通路增强高葡萄糖透析液诱导的腹膜炎症和纤维化
Dongdong Zhu,Xiaohui Huang,Shuyang Bian et al.
Dongdong Zhu et al.
Peritoneal dialysis (PD) is a renal replacement therapy for patients with end-stage renal disease (ESRD). However, long-term PD treatment frequently triggers peritoneal inflammation and mesothelial-to-mesenchymal (MMT), ultimately leading t...
Impact of ventricular pressure load changes on cardiomyocyte proliferation: the role of ALDH2 and GRAF1 [0.03%]
室性压力负荷变化对心肌细胞增殖的影响及其ALDH2和GRAF1的作用机制研究
Peng Cheng,Jieyun Wu,Xiaodan Hao et al.
Peng Cheng et al.
Heart failure is a major clinical challenge, posing a significant health threat due to its high mortality rate. The lack of regenerative capacity in the adult mammalian heart remains a core issue in heart failure treatment. Our previous stu...
STING-associated metabolic changes engage AMPK to amplify interferon signaling in Listeria-infected macrophages [0.03%]
STING相关代谢改变活化AMPK以增强Listeria感染的巨噬细胞中I型干扰素信号转导
Shukun Chen,Xiao Wang,Zhuoyu Duan et al.
Shukun Chen et al.
Innate immune activation is tightly coupled to metabolic remodeling, yet how STING-associated signaling intersects with macrophage metabolism during bacterial infection remains incompletely understood. Here, using Listeria monocytogenes inf...