Matthew John Wakefield,Ksenija Nesic,Olga Kondrashova et al.
Matthew John Wakefield et al.
Novel insights into breast cancer progression and metastasis: A multidisciplinary opportunity to transition from biology to clinical oncology [0.03%]
乳腺癌进展和转移的新见解：从生物学过渡到临床肿瘤学的多学科机会
Manuel Scimeca,Nicoletta Urbano,Rita Bonfiglio et al.
Manuel Scimeca et al.
According to the most recent epidemiological studies, breast cancer shows the highest incidence and the second leading cause of death in women. Cancer progression and metastasis are the main events related to poor survival of breast cancer ...
Theresa K Leslie,Andrew D James,Fulvio Zaccagna et al.
Theresa K Leslie et al.
The concentration of sodium ions (Na+) is raised in solid tumours and can be measured at the cellular, tissue and patient levels. At the cellular level, the Na+ gradient across the membrane powers the transport of H+ ions and essential nutr...
Fibroblasts in cancer: Defining target structures for therapeutic intervention [0.03%]
癌症中的纤维母细胞：确定治疗性干预的目标结构
Maximilian Boesch,Florent Baty,Holger Rumpold et al.
Maximilian Boesch et al.
The functional importance of the tumor stroma for cancer growth and progression is increasingly recognized, but has not resulted in notable therapeutic developments yet. Within the mesenchymal tumor microenvironment, cancer-associated fibro...
Comprehensive elaboration of database resources utilized in next-generation sequencing-based tumor somatic mutation detection [0.03%]
基于下一代测序的肿瘤体细胞突变检测中所用数据库资源的详述
Peng Gao,Rui Zhang,Jinming Li
Peng Gao
The rapid evolution of next-generation sequencing (NGS)-based tumor genomic profile detection and the emergence of molecularly targeted therapies have enabled precision oncology. In NGS-based analysis, various types of databases have been d...
Metastasis as a systemic disease: molecular insights and clinical implications [0.03%]
转移作为系统性疾病：分子见解及其临床意义
Maša Alečković,Sandra S McAllister,Kornelia Polyak
Maša Alečković
Metastasis is a complex systemic disease that develops as a result of interactions between tumor cells and their local and distant microenvironments. Local and systemic immune-related changes play especially critical roles in limiting or en...
Bacterial biofilms as a potential contributor to mucinous colorectal cancer formation [0.03%]
细菌生物膜可能促进粘液性结直肠癌形成
Shan Li,Maikel P Peppelenbosch,Ron Smits
Shan Li
A prominent mucinous phenotype is observed in 10-15% of all colorectal cancers (CRCs). They are associated with a proximal location, and more commonly observed among tumors with mismatch repair defects and a promoter CpG methylator phenotyp...
FLT3 overexpression in acute leukaemias: New insights into the search for molecular mechanisms [0.03%]
急性白血病中的FLT3过度表达：寻找分子机制的新见解
Caroline Pires Poubel,Marcela B Mansur,Mariana Boroni et al.
Caroline Pires Poubel et al.
FLT3 overexpression is a recurrent event in various acute leukaemia subtypes. This transcriptional deregulation is important to define the prognostic risk for many patients. Of note, the molecular mechanisms leading to this gene upregulatio...
Sneha Vivekanadhan,Debabrata Mukhopadhyay
Sneha Vivekanadhan
Plexin D1 belongs to a family of transmembrane proteins called plexins. It was characterized as a receptor for semaphorins and is known to be essential for axonal guidance and vascular patterning. Mutations in Plexin D1 have been implicated...
From genetics to signaling pathways: molecular pathogenesis of esophageal adenocarcinoma [0.03%]
从遗传学到信号通路：食管腺癌的分子发病机制
Ravindran Caspa Gokulan,Monica T Garcia-Buitrago,Alexander I Zaika
Ravindran Caspa Gokulan
Esophageal adenocarcinoma (EAC) has one of the fastest rising incidence rates in the U.S. and many other Western countries. One of the unique risk factors for EAC is gastroesophageal reflux disease (GERD), a chronic digestive condition in w...