The double-edged sword of IRF7: "Guardian" or "traitor" of tumors? From mechanistic contradictions to therapeutic revolution [0.03%]
双刃剑的IRF7：肿瘤的“守护者”还是“叛徒”？从机制矛盾到治疗革命
Siyu Li,Qiong Luo,Jiali Hu et al.
Siyu Li et al.
Interferon Regulatory Factor 7 (IRF7) is emerging as a pivotal and paradoxical modulator in cancer biology, functioning both as a tumor suppressor and as a context-dependent oncogenic driver. This review not only covers classical features s...
Beyond repair: Expanding roles of BRCA1 in RNA processing and cancer [0.03%]
超越修复：BRCA1在RNA处理和癌症中的作用扩展
Mahsa Rastegar Moghaddam Poorbagher,Manuela Santarosa
Mahsa Rastegar Moghaddam Poorbagher
BRCA1 is widely recognized as a guardian of the genome due to its established roles in DNA damage repair and cell cycle regulation. Nevertheless, these functions alone do not fully account for the tissue-specific defects and tumor phenotype...
Michela Corsini,Mattia Domenichini,Elisa Moreschi et al.
Michela Corsini et al.
Metastatic cancer cells display a remarkable ability to resist the mechanical and biochemical challenges associated with detaching from the extracellular matrix and metastasize. A key adaptive mechanism in this process is resistance to anoi...
Decoding the epigenetic landscape: ctDNA methylation as a game-changer in hepatocellular carcinoma management [0.03%]
表观遗传景观的解密：ctDNA甲基化在肝细胞癌管理中的变革作用
Dexin Yang,Yueru Yao,Fenfang Gui et al.
Dexin Yang et al.
Hepatocellular carcinoma (HCC) constitutes a pressing global health issue, where conventional diagnostics like alpha-fetoprotein (AFP) and ultrasonography reveal limitations in early identification and prognostic reliability. Circulating tu...
Rewiring PD-1/PD-L1 combination therapy via glyco-immune targeting of galectins: Toward clinical translation [0.03%]
通过糖免疫靶向半乳糖凝集素重构PD-1 / PD-L1联合疗法：走向临床转化
Xiangyu Huang,Si Zhang,Jiale Li et al.
Xiangyu Huang et al.
Despite advances in PD-1/PD-L1 combination therapies, clinical benefits remain limited and toxicity is significant. Galectins, a family of β-galactoside-binding lectins, have emerged as mechanistically distinct, multimodal targets with the...
Reza Izadpanah,Amin Izadpanah,Eckhard U Alt
Reza Izadpanah
Angiogenesis is a highly coordinated process essential for development, tissue homeostasis, and repair. In physiologic settings, endothelial cells remain quiescent until transient hypoxia- or injury-induced surges of VEGF (vascular endothel...
Keratinocyte organelle reprogramming as a key player in melanocyte biology in health and disease [0.03%]
角质形成细胞器重编程在黑素细胞生物学中的作用：健康与疾病的视角
Sophia N Baptista,Alessandra V S Faria,Carmen V Ferreira-Halder
Sophia N Baptista
Melanoma, an aggressive skin cancer, poses significant global health challenges due to its increasing incidence and high metastatic potential. While traditionally focused on genetic mutations, recent research highlights the critical role of...
mRNA cancer vaccine: A novel and potential immunotherapy for multiple myeloma [0.03%]
针对多发性骨髓瘤的新型潜在免疫治疗手段—mRNA癌症疫苗疗法
Yiming Feng,Yufeng Du,Chengtao Zhang et al.
Yiming Feng et al.
Multiple myeloma (MM) is a malignant haematologic tumour originating from bone marrow plasma cells, characterised by the abnormal proliferation of monoclonal plasma cells, invasion of the bone marrow, and resulting end-organ damage, with co...
Posttranslational modifications in Helicobacter pylori-associated gastric pathogenesis: Bridging inflammation and carcinogenesis [0.03%]
与幽门螺旋杆菌相关胃病发生发展的蛋白质修饰作用：炎症向癌变的发展过程中的信号通路之间的关系
Wei Li,Tong Liu,Tianhua Wu et al.
Wei Li et al.
Helicobacter pylori (H. pylori), a Group I carcinogen that affects approximately half of the global population, is the primary aetiological agent of chronic gastritis, peptic ulcers, gastric adenocarcinoma, and gastric mucosa-associated lym...
Opposing roles of YY1 and RKIP in cancer progression and therapy resistance [0.03%]
YY1和RKIP在癌症进展和治疗抵抗中的相反作用
Christos Rigopoulos,Stavroula Baritaki,Ilias Georgakopoulos-Soares et al.
Christos Rigopoulos et al.
Yin Yang 1 (YY1) and Raf kinase inhibitory protein (RKIP, encoded by PEBP1) are multifunctional regulators with antagonistic roles in tumor biology. YY1 functions as a context-dependent transcription factor and chromatin organizer, integrat...