Principles and methods of integrative chromatin analysis in primary tissues and tumors [0.03%]
原代组织和肿瘤中整合分析染色质的原则与方法学
Paloma Cejas,Henry W Long
Paloma Cejas
Recent methodological advances have enabled the genome-wide interrogation of chromatin from primary tumor tissues. Integrative analysis of histone post-translational modifications, transcription factor (TF) binding and open chromatin sites ...
Lan Huang,Cindy Wang,Huaxi Xu et al.
Lan Huang et al.
An important feature shared by many cancer cells is drastically altered metabolism that is critical for rapid growth and proliferation. The distinctly reprogrammed metabolism in cancer cells makes it possible to manipulate the levels of met...
The intricate relationship between diabetes, obesity and pancreatic cancer [0.03%]
糖尿病、肥胖和胰腺癌之间的复杂关系
Silvano Paternoster,Marco Falasca
Silvano Paternoster
Pancreatic cancer is one of the leading determinants of global cancer mortality, and its incidence is predicted to increase, to become in 2030 the second most common cause of cancer-related death. Obesity and diabetes are recognized risk fa...
Venous thromboembolism GWAS reported genetic makeup and the hallmarks of cancer: Linkage to ovarian tumour behaviour [0.03%]
静脉血栓栓塞GWAS报道的遗传构成与癌症的特点：与卵巢肿瘤行为的关系
Valéria Tavares,Ricardo Pinto,Joana Assis et al.
Valéria Tavares et al.
Venous thromboembolism (VTE) is a common cardiovascular disease thought to be the outcome of an intricate interplay between acquired and inherited factors that act together to modify disease risk. Over the years, several single-nucleotide p...
David Anwanwan,Santosh Kumar Singh,Shriti Singh et al.
David Anwanwan et al.
Globally, liver cancer is the most frequent fatal malignancy; in the United States, it ranks fifth. Patients are often diagnosed with liver cancer in advanced stages, contributing to its poor prognosis. Of all liver cancer cases, >90% are h...
Harnessing the therapeutic potential of anticancer drugs through amorphous solid dispersions [0.03%]
通过无定形固体分散体技术挖掘抗癌药物的治疗潜力
Urvi H Gala,Dave A Miller,Robert O Williams rd
Urvi H Gala
The treatment of cancer is still a major challenge. But tremendous progress in anticancer drug discovery and development has occurred in the last few decades. However, this progress has resulted in few effective oncology products due to cha...
Elevating pancreatic cystic lesion stratification: Current and future pancreatic cancer biomarker(s) [0.03%]
胰腺囊性病变的分层诊断：当前和未来的胰腺癌生物标志物
Joseph Carmicheal,Asish Patel,Vipin Dalal et al.
Joseph Carmicheal et al.
Pancreatic ductal adenocarcinoma (PDAC) is an incredibly deadly disease with a 5-year survival rate of 9%. The presence of pancreatic cystic lesions (PCLs) confers an increased likelihood of future pancreatic cancer in patients placing them...
D Farhat,H Lincet
D Farhat
We discuss how lipoic acid (LA), a natural antioxidant, induces apoptosis and inhibits proliferation, EMT, metastasis and stemness of cancer cells. Furthermore, owing to its ability to reduce chemotherapy-induced side effects and chemoresis...
Ke Wang,Xin-Hui Zhao,Jun Liu et al.
Ke Wang et al.
The nervous system has been recently shown to exert impact on gastric cancer directly and indirectly. Gastric cancer cells invade nerve fibers to induce outgrowth and branching of neural cells, and nerve fibers in turn infiltrate into tumor...
The association between type of endocrine therapy and development of estrogen receptor-1 mutation(s) in patients with hormone-sensitive advanced breast cancer: A systematic review and meta-analysis of randomized and non-randomized trials [0.03%]
内分泌治疗类型与激素敏感型晚期乳腺癌患者雌激素受体-1突变发展的关联：随机试验和非随机试验的系统评价和荟萃分析
Omar Najim,Sofie Seghers,Laurine Sergoynne et al.
Omar Najim et al.
Background: Breast cancer has, due to its high incidence, the highest mortality of cancer in women. The most common molecular type of breast cancer is the luminal subtype, which expresses estrogen and progesterone recepto...