Cholesterol and beyond - The role of the mevalonate pathway in cancer biology [0.03%]
胆固醇与更广泛的领域——甲羟戊酸途径在癌症生物学中的作用
Andy Göbel,Martina Rauner,Lorenz C Hofbauer et al.
Andy Göbel et al.
Cancer is a multifaceted global disease. Transformation of a normal to a malignant cell takes several steps, including somatic mutations, epigenetic alterations, metabolic reprogramming and loss of cell growth control. Recently, the mevalon...
Epigenetic memory in development and disease: Unraveling the mechanism [0.03%]
表观遗传记忆在发育和疾病中的作用及机制研究
Sam Thiagalingam
Sam Thiagalingam
Epigenetic memory is an essential process of life that governs the inheritance of predestined functional characteristics of normal cells and the newly acquired properties of cells affected by cancer and other diseases from parental to proge...
Multiple roles and context-specific mechanisms underlying YAP and TAZ-mediated resistance to anti-cancer therapy [0.03%]
YAP和TAZ介导的抵抗抗癌治疗的多重作用及特定机制
Francesca Reggiani,Giulia Gobbi,Alessia Ciarrocchi et al.
Francesca Reggiani et al.
Understanding the molecular mechanisms driving resistance to anti-cancer drugs is both a crucial step to define markers of response to therapy and a clinical need in many cancer settings. YAP and TAZ transcriptional cofactors behave as onco...
Communication in tiny packages: Exosomes as means of tumor-stroma communication [0.03%]
通讯微包：通过外泌体进行肿瘤间质通讯
Juliane Daßler-Plenker,Victoria Küttner,Mikala Egeblad
Juliane Daßler-Plenker
Tumor-derived exosomes are nano-sized vesicles acting as multi-signal devices influencing tumor growth at local and distant sites. Exosomes are derived from the endolysosomal compartment and can shuttle diverse biomolecules like nucleic aci...
Liliana Raimundo,Helena Ramos,Joana B Loureiro et al.
Liliana Raimundo et al.
Increasing emphasis has been given to prevention as a feasible approach to reduce the cancer burden. However, for its clinical success, further advances are required to identify effective chemopreventive agents. This review affords a critic...
The emerging role of paraptosis in tumor cell biology: Perspectives for cancer prevention and therapy with natural compounds [0.03%]
旁细胞死亡在肿瘤细胞生物学中的作用及其利用天然化合物进行癌症预防和治疗的前景
Fabrizio Fontana,Michela Raimondi,Monica Marzagalli et al.
Fabrizio Fontana et al.
Standard anti-cancer therapies promote tumor growth suppression mainly via induction of apoptosis. However, in most cases cancer cells acquire the ability to escape apoptotic cell death, thus becoming resistant to current treatments. In thi...
RLIP controls receptor-ligand signaling by regulating clathrin-dependent endocytosis [0.03%]
RLIP调控受体-配体信号转导的机制研究及其依赖于网格蛋白的内吞作用 регуляция клатринозависимой эндоцитозом(signaling)
Sharad S Singhal,Ravi Salgia,Nisan Verma et al.
Sharad S Singhal et al.
RLIP (Ral-interacting protein) is a multifunctional protein that couples ATP hydrolysis with the movement of substances. Its primary function appears to be in the plasma membrane, where it catalyzes the ATP-dependent efflux of glutathione-c...
The conflicting role of E2F1 in prostate cancer: A matter of cell context or interpretational flexibility? [0.03%]
E2F1在前列腺癌中的矛盾作用：由细胞类型决定还是解释的灵活性导致？
Jung Nyeo Chun,Minsoo Cho,Soonbum Park et al.
Jung Nyeo Chun et al.
The transcription factor E2F1 plays a crucial role in mediating multiple cancer hallmark capabilities that regulate cell cycle, survival, apoptosis, metabolism, and metastasis. Aberrant activation of E2F1 is closely associated with a poor c...
The role of AhR in transcriptional regulation of immune cell development and function [0.03%]
AhR在免疫细胞发育和功能的转录调控中的作用
Prashant Trikha,Dean A Lee
Prashant Trikha
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcriptional factor (TF) that is a member of the Per-Arnt-Sim family of proteins. AhR regulates diverse processes, including malignant transformation, hematopoietic cell developme...
Mechanism of colorectal carcinogenesis triggered by heme iron from red meat [0.03%]
红肉中的血基铁引发结直肠癌发生的机制研究
Nina Seiwert,Daniel Heylmann,Solveig Hasselwander et al.
Nina Seiwert et al.
Colorectal cancer (CRC) is one of the major tumor entities worldwide, with an increasing incidence in younger people. CRC formation is causally linked to various genetic, life-style and dietary risk factors. Among the ladder, the consumptio...