RON receptor tyrosine kinase in pancreatic ductal adenocarcinoma: Pathogenic mechanism in malignancy and pharmaceutical target for therapy [0.03%]
胰腺导管腺癌中RON酪氨酸激酶的致癌机制及其作为药物治疗靶点的作用
Hang-Ping Yao,Rachel Hudson,Ming-Hai Wang
Hang-Ping Yao
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers with poor prognosis and high mortality. Molecular aberrations associated with PDAC pathogenesis and progression have been extensively investigated. Nevertheless, ...
Advances in cancer cachexia: Intersection between affected organs, mediators, and pharmacological interventions [0.03%]
癌症恶病质的研究进展：受累器官、介质和药物干预的交叉点
Jawed A Siddiqui,Ramesh Pothuraju,Maneesh Jain et al.
Jawed A Siddiqui et al.
Advanced cancer patients exhibit cachexia, a condition characterized by a significant reduction in the body weight predominantly from loss of skeletal muscle and adipose tissue. Cachexia is one of the major causes of morbidity and mortality...
Simone Aparecida de Bessa Garcia,Mafalda Araújo,Tiago Pereira et al.
Simone Aparecida de Bessa Garcia et al.
Breast cancer develops in the mammary glands during mammalian adulthood and is considered the second most common type of human carcinoma and the most incident and mortal in the female population. In contrast to other human structures, the f...
Ranadip Mandal,Joan Compte Barrón,Izabela Kostova et al.
Ranadip Mandal et al.
Caspase-8 is a cysteine - aspartate specific protease that classically triggers the extrinsic apoptotic pathway, in response to the activation of cell surface Death Receptors (DRs) like FAS, TRAIL-R and TNF-R. Besides it's roles in triggeri...
Bram Piersma,Mary-Kate Hayward,Valerie M Weaver
Bram Piersma
Tumors are characterized by extracellular matrix (ECM) deposition, remodeling, and cross-linking that drive fibrosis to stiffen the stroma and promote malignancy. The stiffened stroma enhances tumor cell growth, survival and migration and d...
HERG channel and cancer: A mechanistic review of carcinogenic processes and therapeutic potential [0.03%]
HERG通道与癌症：致癌过程和治疗潜力的机制综述
Siyi He,Mohamed Taha Moutaoufik,Saadul Islam et al.
Siyi He et al.
The human ether-à-go-go related gene (HERG) encodes the alpha subunit of Kv11.1, which is a voltage-gated K+ channel protein mainly expressed in heart and brain tissue. HERG plays critical role in cardiac repolarization, and mutations in H...
Role of fibrillin-2 in the control of TGF-β activation in tumor angiogenesis and connective tissue disorders [0.03%]
纤连蛋白-2在肿瘤血管生成和结缔组织疾病中对TGF-β活化的调控作用
Karlijn van Loon,Julia Yemelyanenko-Lyalenko,Coert Margadant et al.
Karlijn van Loon et al.
Fibrillins constitute a family of large extracellular glycoproteins which multimerize to form microfibrils, an important structure in the extracellular matrix. It has long been assumed that fibrillin-2 was barely present during postnatal li...
Meng Cheng,Zheng Wei Zhang,Xing Hu Ji et al.
Meng Cheng et al.
Glioma is the most common primary malignant tumor in the human brain. Although there are a variety of treatments, such as surgery, radiation and chemotherapy, glioma is still an incurable disease. Super-enhancers (SEs) are implicated in the...
Control of tumor angiogenesis and metastasis through modulation of cell redox state [0.03%]
通过调节细胞氧化还原状态控制肿瘤血管生成和转移
José J Serrano,Belén Delgado,Miguel Ángel Medina
José J Serrano
Redox reactions pervade all biology. The control of cellular redox state is essential for bioenergetics and for the proper functioning of many biological functions. This review traces a timeline of findings regarding the connections between...
Application of organoids in translational research of human diseases with a particular focus on gastrointestinal cancers [0.03%]
类器官在人类疾病转化研究中的应用——特别是胃肠道癌症
Romario Nguyen,Sarah Da Won Bae,Gang Zhou et al.
Romario Nguyen et al.
Gastrointestinal (GI) cancers constitute the largest portion of all human cancers and represent a significant health burden on modern society. Conventional therapeutic approaches such as chemotherapy and surgical resections often fail due t...