Zhongqin Gong,Jianqing Yu,Shucai Yang et al.
Zhongqin Gong et al.
The pathogenesis of hepatocellular carcinoma (HCC) is a multistep process, involving the progressive accumulation of molecular alterations and transcriptomic alterations. The Forkhead-box (FOX) transcription factor family is characterized b...
Jun-O Jin,Gyurin Kim,Juyoung Hwang et al.
Jun-O Jin et al.
Cancer is one of the most prevalent potentially lethal diseases. With the increase in the number of investigations into the uses of nanotechnology, many nucleic acid (NA)-based nanostructures such as small interfering RNA, microRNA, aptamer...
CRISPR screen in mechanism and target discovery for cancer immunotherapy [0.03%]
用于癌症免疫治疗的机制和靶点发现的CRISPR筛选技术
Dan Liu,Xuan Zhao,Anqun Tang et al.
Dan Liu et al.
CRISPR/Cas-based genetic perturbation screens have emerged as powerful tools for large-scale identification of new targets for cancer immunotherapy. Various strategies of CRISPR screen have been used for immune-oncology (IO) target discover...
Molecular subtyping in pancreatic neuroendocrine neoplasms: New insights into clinical, pathological unmet needs and challenges [0.03%]
胰腺神经内分泌肿瘤的分子分型：临床和病理需求及挑战的新见解
Jie Yan,Shuangni Yu,Congwei Jia et al.
Jie Yan et al.
Pancreatic neuroendocrine neoplasms (PanNENs) contain two primary subtypes with distinct molecular features and associated clinical outcomes: well-differentiated neuroendocrine tumors (NETs) and poorly differentiated neuroendocrine carcinom...
Enzyme-based autophagy in anti-neoplastic management: From molecular mechanisms to clinical therapeutics [0.03%]
基于酶的自噬在抗肿瘤管理中的作用：从分子机制到临床治疗
Amir Ajoolabady,Ayuob Aghanejad,Yaguang Bi et al.
Amir Ajoolabady et al.
Autophagy is an evolutionarily conserved self-cannibalization process commonly found in all eukaryotic cells. Through autophagy, long-lived or damaged organelles, superfluous proteins, and pathogens are sequestered and encapsulated into the...
Functionally analyzing the important roles of hepatocyte nuclear factor 3 (FoxA) in tumorigenesis [0.03%]
功能分析肝细胞核因子3（FoxA）在肿瘤发生中的重要作用
Bing Gao,Wei Xie,Xueji Wu et al.
Bing Gao et al.
Transcriptional factors (TFs) play a central role in governing gene expression under physiological conditions including the processes of embryonic development, metabolic homeostasis and response to extracellular stimuli. Conceivably, the ab...
Odyssey of trefoil factors in cancer: Diagnostic and therapeutic implications [0.03%]
三叶草因子在癌症中的诊断和治疗意义： Odyssey之旅
Rahat Jahan,Ashu Shah,Sophia G Kisling et al.
Rahat Jahan et al.
Trefoil factors 1, 2, and 3 (TFFs) are a family of small secretory molecules involved in the protection and repair of the gastrointestinal tract (GI). TFFs maintain and restore epithelial structural integrity via transducing key signaling p...
The rise of T-type channels in melanoma progression and chemotherapeutic resistance [0.03%]
T型通道在黑色素瘤发展和化疗耐药中的作用
Lía Alza,Anna Visa,Judit Herreros et al.
Lía Alza et al.
Hyperactivation of the Mitogen Activated Protein Kinase (MAPK) pathway is prevalent in melanoma, principally due to mutations in the BRAF and NRAS genes. MAPK inhibitors are effective only short-term, and recurrence occurs due to functional...
Circulating tumour DNA: A new biomarker to monitor resistance in NSCLC patients treated with EGFR-TKIs [0.03%]
循环肿瘤DNA：监测EGFR-TKI治疗NSCLC患者耐药性的新型生物标志物
Zhenli Diao,Yanxi Han,Rui Zhang et al.
Zhenli Diao et al.
Targeted molecular therapies have markedly improved the therapeutic management of lung cancer, while the discovery of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) has revolutionized the treatment of non-small cell...
Yuting Jiang,Chengdi Wang,Shengtao Zhou
Yuting Jiang
Ovarian cancer is the leading cause of gynecological cancer-related mortality globally. The majority of ovarian cancer patients suffer from relapse after standard of care therapies and the clinical benefits from cancer therapies are not sat...