Atieh Yaghoubi,Majid Khazaei,Saba Jalili et al.
Atieh Yaghoubi et al.
Bacteria have long been known as one of the primary causative agents of cancer, however, recent studies suggest that they can be used as a promising agent in cancer therapy. Because of the limitations that conventional treatment faces due t...
Local and systemic immunosuppression in pancreatic cancer: Targeting the stalwarts in tumor's arsenal [0.03%]
胰腺癌的局部和全身免疫抑制：针对肿瘤“武器库”中的关键因素进行靶向治疗
Clara S Mundry,Kirsten C Eberle,Pankaj K Singh et al.
Clara S Mundry et al.
Late detection, compromised immune system, and chemotherapy resistance underlie the poor patient prognosis for pancreatic ductal adenocarcinoma (PDAC) patients, making it the 3rd leading cause of cancer-related deaths in the United States. ...
Immunomodulatory effects of ablation therapy on tumors: Potentials for combination with immunotherapy [0.03%]
消融治疗的免疫调控作用及其与免疫治疗联合使用的潜力
Ling Qian,Yehua Shen,Jing Xie et al.
Ling Qian et al.
As a promising area of tumor treatment, immunotherapies, such as immune checkpoint inhibitors, have been applied to various types of cancer. However, many patients do not respond to such therapies. Increasing application of tumor ablation t...
Priming the tumor immune microenvironment with chemo(radio)therapy: A systematic review across tumor types [0.03%]
化疗（放疗）激活肿瘤免疫微环境的系统性回顾研究：跨瘤种分析
Tom van den Ende,Héctor G van den Boorn,Nadine M Hoonhout et al.
Tom van den Ende et al.
Background: Chemotherapy (CT), radiotherapy (RT), and chemoradiotherapy (CRT) are able to alter the composition of the tumor immune microenvironment (TIME). Understanding the effect of these modalities on the TIME could a...
Cardiovascular risks and toxicity - The Achilles heel of androgen deprivation therapy in prostate cancer patients [0.03%]
心血管风险和毒性-雄激素剥夺治疗的阿喀琉斯之踵（前列腺癌患者）
Sakthivel Muniyan,Lei Xi,Kaustubh Datta et al.
Sakthivel Muniyan et al.
Androgen deprivation therapy (ADT) is the primary systemic therapy for treating locally advanced or metastatic prostate cancer (PCa). Despite its positive effect on PCa patient survival, ADT causes various adverse effects, including increas...
Tian-Jiao Li,Wen-Quan Wang,Xian-Jun Yu et al.
Tian-Jiao Li et al.
Cancer regression often fails after systemic immune activation, especially for solid tumors due to their local immunosuppressive microenvironments. Among these, the pancreatic cancer microenvironment is unique and an important reason for re...
New insights on sorafenib resistance in liver cancer with correlation of individualized therapy [0.03%]
索拉非尼耐药肝癌的新认知及其个体化治疗的关联性研究
Zhang Cheng,Jiang Wei-Qi,Ding Jin
Zhang Cheng
Liver cancer is highly malignant and insensitive to cytotoxic chemotherapy and is associated with very poor patient prognosis. In 2007, the small-molecule targeted drug sorafenib was approved for the treatment of advanced liver cancer. In t...
Gambogic acid: A shining natural compound to nanomedicine for cancer therapeutics [0.03%]
gambogic酸：用于癌症治疗的天然化合物纳米药物明星
Elham Hatami,Meena Jaggi,Subhash C Chauhan et al.
Elham Hatami et al.
The United States Food and Drug Administration has permitted number of therapeutic agents for cancer treatment. Most of them are expensive and have some degree of systemic toxicity which makes overbearing in clinical settings. Although adva...
Emerging functions and clinical prospects of connexins and pannexins in melanoma [0.03%]
连接蛋白和泛连蛋白在黑色素瘤中功能及临床应用的新进展
Adrián Varela-Vázquez,Amanda Guitián-Caamaño,Paula Carpintero-Fernandez et al.
Adrián Varela-Vázquez et al.
Cellular communication through gap junctions and hemichannels formed by connexins and through channels made by pannexins allows for metabolic cooperation and control of cellular activity and signalling. These channel proteins have been desc...
Therapeutic aspects of AMPK in breast cancer: Progress, challenges, and future directions [0.03%]
AMPK在乳腺癌治疗中的作用：进展、挑战和未来方向
Lavanya Ponnusamy,Sathan Raj Natarajan,Karthik Thangaraj et al.
Lavanya Ponnusamy et al.
Breast cancer is the most ubiquitous type of neoplasms among women worldwide. Molecular aberrations associated with breast development and progressions have been extensively investigated in recent years. An AMP-activated kinase (AMPK) initi...