MCM family in gastrointestinal cancer and other malignancies: From functional characterization to clinical implication [0.03%]
胃肠道癌症和其他恶性肿瘤中的MCM家族：从功能特征到临床影响
Yifei Wang,Huarong Chen,Jinglin Zhang et al.
Yifei Wang et al.
Despite the recent advances in cancer research and treatment, gastrointestinal (GI) cancers remain the most common deadly disease worldwide. The aberrant DNA replication serves as a major source of genomic instability and enhances cell prol...
Resistin: An inflammatory cytokine with multi-faceted roles in cancer [0.03%]
Resistin：具有多种癌症作用的炎症细胞因子
Sarabjeet Kour Sudan,Sachin Kumar Deshmukh,Teja Poosarla et al.
Sarabjeet Kour Sudan et al.
Systemic and organ-confined inflammation has been associated with cancer development and progression. Resistin, initially described as an adipocyte-derived cytokine in mice, is mostly expressed by the macrophages in humans. It has potent pr...
Biophysical signal transduction in cancer cells: Understanding its role in cancer pathogenesis and treatment [0.03%]
癌细胞中的生物物理信号转导：理解其在癌症发病机制和治疗中的作用
XiaoLei Huang,XiaoXu Yang,Chenchen Sun et al.
XiaoLei Huang et al.
Signaling between cells can promote both the development and progression of cancer. It has been found that chemical and physical signals, together with extracellular factors, can influence cancer progression. In this review, we focus on the...
Classification of extrachromosomal circular DNA with a focus on the role of extrachromosomal DNA (ecDNA) in tumor heterogeneity and progression [0.03%]
染色体外环状DNA的分类，重点介绍染色体外DNA（ecDNA）在肿瘤异质性和进展中的作用
Zhenyu Liao,Wang Jiang,Longyun Ye et al.
Zhenyu Liao et al.
Although the eukaryotic genome is mainly comprised of linear chromosomal DNA, genes can also be found outside of chromosomes. The unconventional presence of extrachromosomal genes is usually found to be circular, and these structures are na...
Extracellular vesicle-based liquid biopsy holds great promise for the management of ovarian cancer [0.03%]
基于细胞外囊泡的液体活检在卵巢癌管理中前景广阔
Xiaocui Zheng,Xiaoduan Li,Xipeng Wang
Xiaocui Zheng
Ovarian cancer is a highly lethal gynecological disease because most patients are diagnosed in advanced stages due to a lack of appropriate markers or methods for early detection. Extracellular vesicles (EVs) are small biological vesicles r...
Cholesterol metabolism: New functions and therapeutic approaches in cancer [0.03%]
胆固醇代谢：癌症中的新功能和治疗途径
Huanji Xu,Sheng Zhou,Qiulin Tang et al.
Huanji Xu et al.
Cholesterol and its metabolites (precursors and derivatives) play an important role in cancer. In recent years, numerous studies have reported the functions of cholesterol metabolism in the regulation of tumor biological processes, especial...
PERP-ing into diverse mechanisms of cancer pathogenesis: Regulation and role of the p53/p63 effector PERP [0.03%]
探究癌症发生发展多样机制的PERP蛋白：PERP对p53和p63的作用及调控功能研究
Owain Roberts,Luminita Paraoan
Owain Roberts
The tetraspan plasma membrane protein PERP (p53 apoptosis effector related to PMP22) is a lesser-known transcriptional target of p53 and p63. A member of the PMP22/GAS3/EMP membrane protein family, PERP was originally identified as a p53 ta...
Lenvatinib for hepatocellular carcinoma: From preclinical mechanisms to anti-cancer therapy [0.03%]
仑伐替尼治疗肝细胞癌：从基础研究到抗肿瘤药物疗法
Yan Zhao,Ya-Ni Zhang,Kai-Ting Wang et al.
Yan Zhao et al.
Lenvatinib, a multi-target tyrosine kinase inhibitor (TKI), is an emerging first-line therapy for hepatocellular carcinoma (HCC). Its application has changed the status of sorafenib as the only first-line TKI treatment for HCC for more than...
ETV6 gene aberrations in non-haematological malignancies: A review highlighting ETV6 associated fusion genes in solid tumors [0.03%]
ETV6基因异常在非血液系统肿瘤中的研究进展：综述ETV6融合基因在实体瘤中的关联性
Angana Biswas,Yetirajam Rajesh,Pralay Mitra et al.
Angana Biswas et al.
ETV6 (translocation-Ets-leukemia virus) gene is a transcriptional repressor mainly involved in haematopoiesis and maintenance of vascular networks and has developed to be a major oncogene with the potential ability of forming fusion partner...
Ge Wang,Pengxiu Cao,Yumei Fan et al.
Ge Wang et al.
Heat shock factor 1 (HSF1) systematically guards proteome stability and proteostasis by regulating the expression of heat shock protein (HSP), thus rendering cancer cells addicted to HSF1. The non-canonical transcriptional programme driven ...