Nerve input to tumours: Pathophysiological consequences of a dynamic relationship [0.03%]
肿瘤的神经输入：一种动态关系的病理生理后果
Charlotte Hutchings,Jade A Phillips,Mustafa B A Djamgoz
Charlotte Hutchings
It is well known that tumours arising in different organs are innervated and that 'perineural invasion' (cancer cells escaping from the tumour by following the nerve trunk) is a negative prognostic factor. More surprisingly, increasing evid...
Cancer regeneration: Polyploid cells are the key drivers of tumor progression [0.03%]
癌症再生：多倍体细胞是肿瘤进展的主要驱动力
Shiva Moein,Rezvan Adibi,Lindolfo da Silva Meirelles et al.
Shiva Moein et al.
In spite of significant advancements of therapies for initial eradication of cancers, tumor relapse remains a major challenge. It is for a long time known that polyploid malignant cells are a main source of resistance against chemotherapy a...
Amoolya Kandettu,Raghu Radhakrishnan,Sanjiban Chakrabarty et al.
Amoolya Kandettu et al.
Micro RNAs (miRNAs) are small non-coding RNAs that are essential for regulation of gene expression of the target genes. Large number of miRNAs are organized into defined units known as miRNA clusters (MCs). The MCs consist of two or more th...
COVID-19 and cancer: A guide with suggested COVID-19 rule-out criteria to support clinical decision-making [0.03%]
COVID-19与癌症：一份含有建议性的排除标准指南以协助临床决策的制定
Christopher Larson,Bryan Oronsky,Sharad Goyal et al.
Christopher Larson et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly contagious zoonotic pathogen that has exacted heavy public health, social and economic tolls. In February 2020, the World Health Organization acronymed the disease cau...
Mechanically stressed cancer microenvironment: Role in pancreatic cancer progression [0.03%]
机械应力的癌症微环境：在胰腺癌进展中的作用
Matthew Hadden,Anubhav Mittal,Jaswinder Samra et al.
Matthew Hadden et al.
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid malignancies in the world due to its insensitivity to current therapies and its propensity to metastases from the primary tumor mass. This is largely attributed to its ...
Roles of CA19-9 in pancreatic cancer: Biomarker, predictor and promoter [0.03%]
CA19-9在胰腺癌中的作用：生物标志物，预测因子和促进者
Guopei Luo,Kaizhou Jin,Shengming Deng et al.
Guopei Luo et al.
Carbohydrate antigen 19-9 (CA19-9) is the best validated biomarker and an indicator of aberrant glycosylation in pancreatic cancer. CA19-9 functions as a biomarker, predictor, and promoter in pancreatic cancer. As a biomarker, the sensitivi...
Human MYC G-quadruplex: From discovery to a cancer therapeutic target [0.03%]
人类MYC G-四链体：从发现到癌症治疗靶点
Wenmeng Wang,Shuangli Hu,Yaru Gu et al.
Wenmeng Wang et al.
Overexpression of the MYC oncogene is a molecular hallmark of both cancer initiation and progression. Targeting MYC is a logical and effective cancer therapeutic strategy. A special DNA secondary structure, the G-quadruplex (G4), is formed ...
The biology and engineered modeling strategies of cancer-nerve crosstalk [0.03%]
癌症与神经相互作用的生物学及工程化建模策略
Emory Gregory,Reagan Dugan,Gabriel David et al.
Emory Gregory et al.
A recent finding critical to cancer aggravation is the interaction between cancer cells and nerves. There exist two main modes of cancer-nerve interaction: perineural invasion (PNI) and tumor innervation. PNI occurs when cancer cells infilt...
Chuanxi Zheng,Fan Tang,Li Min et al.
Chuanxi Zheng et al.
Osteosarcoma is the most common primary malignant bone tumor, predominantly occurring in children and adolescents. Despite treated with surgery and neoadjuvant chemotherapy, osteosarcoma has a high potential of local recurrence and lung met...
Cancer associated fibroblast mediated chemoresistance: A paradigm shift in understanding the mechanism of tumor progression [0.03%]
癌症相关成纤维细胞介导的化疗抗性：对肿瘤进程机制理解的一个范式转移
Bikash Chandra Jena,Chandan Kanta Das,Deblina Bharadwaj et al.
Bikash Chandra Jena et al.
One of the undeniable issues with cancer eradication is the evolution of chemoresistance in due course of treatment, and the mechanisms of chemoresistance have been the subject of extensive research for several years. The efficacy of chemot...