Extracellular proteolysis in glioblastoma progression and therapeutics [0.03%]
胶质母细胞瘤的进展和治疗中的胞外蛋白水解过程
Agathe Quesnel,George S Karagiannis,Panagiota S Filippou
Agathe Quesnel
Gliomas encompass highly invasive primary central nervous system (CNS) tumours of glial cell origin with an often-poor clinical prognosis. Of all gliomas, glioblastoma is the most aggressive form of primary brain cancer. Current treatments ...
Exosomes as Biomarkers of Human and Feline Mammary Tumours; A Comparative Medicine Approach to Unravelling the Aggressiveness of TNBC [0.03%]
外泌体作为人类和猫乳腺肿瘤的生物标志物；比较医学在解开TNBC侵袭性方面的应用
Jane Howard,Cathy Wyse,David Argyle et al.
Jane Howard et al.
Comparative oncology is defined as the discipline that integrates naturally occurring cancers seen in veterinary medicine, into more general studies of cancer biology and therapy in humans, including the study of cancer-pathogenesis and new...
Latest perspectives on glucocorticoid-induced apoptosis and resistance in lymphoid malignancies [0.03%]
淋巴恶性肿瘤中糖皮质激素诱导的凋亡和抗性的最新研究观点
Dorien Clarisse,Fritz Offner,Karolien De Bosscher
Dorien Clarisse
Glucocorticoids are essential drugs in the treatment protocols of lymphoid malignancies. These steroidal hormones trigger apoptosis of the malignant cells by binding to the glucocorticoid receptor (GR), which is a member of the nuclear rece...
The implication of long non-coding RNAs in the diagnosis, pathogenesis and drug resistance of pancreatic ductal adenocarcinoma and their possible therapeutic potential [0.03%]
长非编码RNA对胰腺导管腺癌的诊断、发病机制和药物抵抗的影响及其可能的治疗潜力
Gouri Pandya,Anuradha Kirtonia,Gautam Sethi et al.
Gouri Pandya et al.
Pancreatic ductal adenocarcinoma (PDAC) is one of the lethal malignancies with the lowest median and overall survival rate among all human malignancies. The major problems with the PDAC are the late diagnosis, metastasis, and acquired resis...
Potential diagnostic and therapeutic roles of exosomes in pancreatic cancer [0.03%]
外泌体在胰腺癌诊断和治疗中的潜在作用
Xiangxuan Zhao,Ying Ren,Zaiming Lu
Xiangxuan Zhao
Pancreatic cancer (PaCa) is considered an aggressive but still asymptomatic malignancy. Due to the lack of effective diagnostic markers, PaCa is often diagnosed during late metastatic stages. Besides surgical resection, no other treatment a...
MYBL2 amplification in breast cancer: Molecular mechanisms and therapeutic potential [0.03%]
乳腺癌中的MYBL2基因扩增：分子机制和治疗潜力
Rachel Bayley,Ciara Ward,Paloma Garcia
Rachel Bayley
The MYBL2 gene, also known as B-MYB, is essential to regulate vital cellular processes including cell proliferation, differentiation and DNA repair. Changes in these pathways can facilitate cancer development and as such targeting these pro...
Protein glycosylation in head and neck cancers: From diagnosis to treatment [0.03%]
头颈癌中的蛋白糖基化：从诊断到治疗
Mohammad Rasheduzzaman,Arutha Kulasinghe,Riccardo Dolcetti et al.
Mohammad Rasheduzzaman et al.
Glycosylation is the most common post-translational modification (PTM) of proteins. Malignant tumour cells frequently undergo an alteration in surface protein glycosylation. This phenomenon is also common in cancers of the head and neck, mo...
Metabolic heterogeneity in cancer: An overview and therapeutic implications [0.03%]
癌症中的代谢异质性：概览与治疗意义
Yu Tong,Wei-Qiang Gao,Yanfeng Liu
Yu Tong
Recent research on cancer metabolism has revealed that individual tumors have highly heterogeneous metabolic profiles that contribute to the connective metabolic networks within the tumor and its environment. Indeed, tumor-associated cells ...
The ZAR1 protein in cancer; from epigenetic silencing to functional characterisation and epigenetic therapy of tumour suppressors [0.03%]
癌症中的ZAR1蛋白：从表观遗传沉默到肿瘤抑制因子的功能鉴定和表观遗传治疗
Verena E Deutschmeyer,Antje M Richter
Verena E Deutschmeyer
ZAR1, zygote arrest 1, is a zinc finger protein (C-terminus), which was initially identified in mouse oocytes. Later it was found that its expression is present in various human tissues e.g. lung and kidney. Interestingly, it was observed t...
Choosing tumor mutational burden wisely for immunotherapy: A hard road to explore [0.03%]
明智地选择肿瘤突变负荷用于免疫治疗：一条艰难的探索之路
Rui Li,Dongsheng Han,Jiping Shi et al.
Rui Li et al.
Immunotherapy has revolutionized the treatment of cancer due to its remarkable efficacy and extensive survival benefit in multiple tumor types. However, predictive biomarkers are required to identify patients who are likely to respond to im...