Role of YY1 in pancreatic ductal adenocarcinoma: Mechanisms and therapeutic perspectives [0.03%]
YY1在胰腺导管腺癌中的作用：机制和治疗前景
Pallavi Pellakuru,Rachael Guenter,Niharitha Hariharan et al.
Pallavi Pellakuru et al.
YY1 (Yin Yang 1) is a transcription factor (TF) widely conserved across normal biological cells and solid tumors. It plays a key role in inflammation-related diseases and cancer, particularly pancreatic ductal adenocarcinoma (PDAC). In prec...
Histological transformation in lung cancer: Mechanisms, clinical characteristics, and therapeutic approaches [0.03%]
肺癌的组织学转化：机制、临床特征和治疗策略
Shiyi Liu,Tao Xu,Xiaojing Cao et al.
Shiyi Liu et al.
Lung cancer, the leading cause of cancer-related mortality globally, exhibits remarkable histological plasticity, with non-small cell lung cancer (NSCLC) frequently transforming into small cell lung cancer (SCLC) as a resistance mechanism t...
GABAergic signaling in colorectal cancer: Mechanistic insights, tumor microenvironment crosstalk, and therapeutic opportunities [0.03%]
胃肠癌中的γ-氨基丁酸能信号：机制见解、肿瘤微环境相互作用和治疗机会
Donghao Tang,Paola Orlandi,Qijie Li et al.
Donghao Tang et al.
γ-Aminobutyric acid (GABA) and its receptors have emerged as critical modulators of colorectal cancer (CRC) progression and the tumor microenvironment (TME). Although GABA is traditionally recognized as an inhibitory neurotransmitter in th...
The immunosuppressive microenvironment modulated by glioma-associated mesenchymal stem cells: Current status and potential strategies [0.03%]
胶质瘤相关间充质干细胞调控的免疫抑制微环境：现状及潜在策略
Yuyi Wu,Qiang Liu,Wei Xiang et al.
Yuyi Wu et al.
Glioma, the most prevalent primary malignant tumor of the central nervous system, exhibits aggressive progression and poor prognosis, largely due to its highly immunosuppressive tumor microenvironment (TME). Glioma-associated mesenchymal st...
Meijin Wang,Yunlu Zhang,Zhenhua Li et al.
Meijin Wang et al.
Breast cancer is one of the most prevalent malignant tumours, representing a significant health risk for women. Subtyping of breast cancer is based on gene expression profiles, with five distinct subtypes identified Luminal A, Luminal B, HE...
Inhibition of nucleotide excision repair proteins associated with cancer chemotherapy [0.03%]
与癌症化学疗法相关的核苷酸切除修复蛋白的抑制作用
Francesco Gentile,Emeline Cros-Perrial,Lars Petter Jordheim
Francesco Gentile
DNA repair is involved in the cellular response to alkylating agents used for the treatment of various cancers, decreasing the damages induced by the compounds and thus limiting the efficacy of the drugs. The inhibition of DNA repair should...
Metabolic insights into TAMs and the tumor immune microenvironment: Regulatory mechanisms and therapeutic interventions [0.03%]
巨噬细胞与肿瘤免疫微环境的代谢机制及调控策略
Lei Yang,Yingying Shao,Zewen Zhang et al.
Lei Yang et al.
Tumor-associated macrophages (TAMs) are pivotal regulators of the tumor immune microenvironment exhibiting a dual role in tumor therapy by functioning as both pro-tumorigenic effectors and anti-tumor agents. Tumor cells reprogram macrophage...
The role of tissue factor in the tumor microenvironment and targeted therapy [0.03%]
组织因子在肿瘤微环境中的作用及靶向治疗
Ying Yan,Yifan Li,Dan Zou et al.
Ying Yan et al.
Tissue factor (TF) serves as a pivotal initiator of coagulation and has been extensively acknowledged for its substantial involvement in cancer progression and metastasis. Recent evidence suggests that targeting TF can enhance the infiltrat...
Gynecological malignancy organoids: A game changer for personalized medicine [0.03%]
妇科恶性肿瘤类器官：精准医学的变革者
Ziyang Ding,Xingyu Chang,Xinyu Qu et al.
Ziyang Ding et al.
Recently, the incidence of gynecological malignancies has increased annually, posing a serious threat to women's health. Historically, the emergence and progression of gynecological cancers have primarily been studied using cell lines and a...
Clinical aspect of combined immunotherapy and radiotherapy effect on tumor immune microenvironment in hepatobiliary and pancreatic cancers [0.03%]
免疫治疗与放疗联合治疗对肝胆胰肿瘤免疫微环境影响的临床研究进展
Jun-Jie Cheng,Qiu-Yi Zheng,Yi-Lan Huang et al.
Jun-Jie Cheng et al.
Hepatobiliary and pancreatic cancers (HBPCs) remain among the most aggressive nature and lethal malignancies, presenting formidable challenges in their treatment. Surgical resection remains the cornerstone of curative treatment for early-st...