EpCAM cellular functions in adhesion and migration, and potential impact on invasion: A critical review [0.03%]
EpCAM细胞粘附和迁移功能及其对入侵的潜在影响：一次重要回顾
François Fagotto,Azam Aslemarz
François Fagotto
EpCAM has long been known as a cell surface protein highly expressed in carcinomas. It has since become one of the key cancer biomarkers. Despite its high fame, its actual role in cancer development is still controversial. Beyond a flurry o...
Hepatocyte growth factor/MET and CD44 in colorectal cancer: partners in tumorigenesis and therapy resistance [0.03%]
肝细胞生长因子 / MET和结直肠癌中的CD44：肿瘤发生和治疗抵抗的伙伴
Sander P J Joosten,Marcel Spaargaren,Hans Clevers et al.
Sander P J Joosten et al.
Intestinal epithelial self-renewal is a tightly controlled process, which is critically dependent on WNT signalling. Aberrant activation of the WNT pathway in intestinal stem cells (ISCs) results in constitutive transcription of target gene...
Progress and challenge in development of biotherapeutics targeting MET receptor for treatment of advanced cancer [0.03%]
靶向MET受体的生物治疗药物在晚期癌症治疗中的开发进展与挑战
Hang-Ping Yao,Rachel Hudson,Ming-Hai Wang
Hang-Ping Yao
Advanced epithelial cancers such as gastric, lung, and pancreatic tumors are featured by invasive proliferation, distant metastasis, acquired chemoresistance, and tumorigenic stemness. For the last decade, molecular-targeted therapies using...
Oncometabolites lactate and succinate drive pro-angiogenic macrophage response in tumors [0.03%]
肿瘤中致癌代谢物乳酸和琥珀酸促进促血管生成的巨噬细胞反应
Marjolein M G Kes,Jan Van den Bossche,Arjan W Griffioen et al.
Marjolein M G Kes et al.
Macrophages are innate phagocytic leukocytes that are highly present in solid tumors, where they are referred to as tumor-associated macrophages (TAMs). In solid tumors, the microenvironment is often immunosuppressive and hypoxic regions ar...
Yongheng Shu,Ping Cheng
Yongheng Shu
Macrophages are important effector cells of the innate immune system and are also major components of the tumor microenvironment (TME). Macrophages that are abundant in the TME are called tumor-associated macrophages (TAMs). As TAMs promote...
Balancing neurotrophin pathway and sortilin function: Its role in human disease [0.03%]
神经营养因子路径和sortilin功能的平衡：其在人类疾病中的作用
Minnatallah Al-Yozbaki,Amelia Acha-Sagredo,Alex George et al.
Minnatallah Al-Yozbaki et al.
Neurotensin receptor-3 or sortilin is a vacuolar protein sorting 10 protein domain (Vps10p) has been firstly discovered in the human brain, it acts as receptor or co-receptor of the cell and traffics different proteins within the cell. Sort...
Senescence and castration resistance in prostate cancer: A review of experimental evidence and clinical implications [0.03%]
前列腺癌中的衰老与去势抗性：实验证据和临床含义综述
Valerie J Carpenter,Bhaumik B Patel,Riccardo Autorino et al.
Valerie J Carpenter et al.
The development of Castration-Resistant Prostate Cancer (CRPC) remains a major challenge in the treatment of this disease. While Androgen Deprivation Therapy (ADT) can result in tumor shrinkage, a primary response of Prostate Cancer (PCa) c...
Milica B Gilic,Angela L Tyner
Milica B Gilic
Protein tyrosine kinase 6 (PTK6) is the most well studied member of the PTK6 family of intracellular tyrosine kinases. While it is expressed at highest levels in differentiated cells in the regenerating epithelial linings of the gastrointes...
Juliana Felgueiras,Carmen Jerónimo,Margarida Fardilha
Juliana Felgueiras
Cancer cells take advantage of signaling cascades to meet their requirements for sustained growth and survival. Cell signaling is tightly controlled by reversible protein phosphorylation mechanisms, which require the counterbalanced action ...
Deepti Kailash Nabariya,Reddanna Pallu,Vengala Rao Yenuganti
Deepti Kailash Nabariya
Exosomes, which facilitate intercellular communication, antigen presentation and shuttling of biological agents, were initially thought as the cell's garbage cargo but today, after about 40 years of their discovery, we are now beginning to ...