Unmasking carcinoma-associated fibroblasts: Key transformation player within the tumor microenvironment [0.03%]
揭开癌症相关成纤维细胞的面纱：肿瘤微环境中的关键转变参与者
Qing Meng,Xin Luo,Jiaxin Chen et al.
Qing Meng et al.
Fibroblasts have gained increasing attention in tissue desmoplasia, especially in tumors. Activated fibroblasts from various sources modulate matrix composition and stiffness associated with organ fibrosis as well as tumor progression. More...
Fernando C Baltanás,Natasha Zarich,Jose M Rojas-Cabañeros et al.
Fernando C Baltanás et al.
SOS1 and SOS2 are the most universal and widely expressed family of guanine exchange factors (GEFs) capable or activating RAS or RAC1 proteins in metazoan cells. SOS proteins contain a sequence of modular domains that are responsible for di...
Immunotherapy efficacy on mismatch repair-deficient colorectal cancer: From bench to bedside [0.03%]
错配修复缺陷型结直肠癌的免疫治疗效果：从实验台到病床边
Darleny Y Lizardo,Chaoyuan Kuang,Suisui Hao et al.
Darleny Y Lizardo et al.
Colorectal cancers (CRCs) with deficient mismatch repair (dMMR) or microsatellite instability-high (MSI-H) often have sustained responses to immune checkpoint inhibitors (ICIs) including selective monoclonal antibodies against Program Death...
Cancer-associated fibroblasts in therapeutic resistance of pancreatic cancer: Present situation, predicaments, and perspectives [0.03%]
与胰腺癌治疗抵抗相关的癌症成纤维细胞：现状、困境和展望
Xuan Han,Wu-Hu Zhang,Wen-Quan Wang et al.
Xuan Han et al.
Pancreatic cancer is highly lethal, and the most effective treatment is curative resection followed by chemotherapy. Unfortunately, chemoresistance is an extremely common occurrence, and novel treatment modalities, such as immunotherapy and...
Maria Letizia Taddei,Elisa Pardella,Erica Pranzini et al.
Maria Letizia Taddei et al.
In mammalian cells, tyrosine phosphorylation is one of the main mechanisms responsible for regulating signal transduction pathways and key cellular functions. Moreover, recent studies demonstrated that tyrosine phosphorylation influences th...
Drug tolerance to target therapy in melanoma revealed at single cell level: What next? [0.03%]
黑色素瘤单细胞水平揭示了针对药物耐受性的治疗目标：接下来是什么？
Domenico Liguoro,Luigi Fattore,Rita Mancini et al.
Domenico Liguoro et al.
Drug resistance strongly impairs the efficacy of virtually every kind of anticancer therapy. This phenomenon is commonly fueled by intrinsic or acquired mechanisms. In this mini-review, focusing on BRAF-mutated melanoma as prototypical exam...
Li Zhang,Jia Ding,Hui-Yan Li et al.
Li Zhang et al.
A couple of molecular-targeting medications, such as Lenvatinib, are available for the treatment of hepatocellular carcinoma (HCC) in addition to Sorafenib in an advanced stage. Approval for the use of immune check-point inhibitors, such as...
P53 in skin cancer: From a master player to a privileged target for prevention and therapy [0.03%]
皮肤癌中的p53：从一个核心角色到预防和治疗的优先目标
J B Loureiro,M Abrantes,P A Oliveira et al.
J B Loureiro et al.
The increasing incidence of skin cancer (SC) is a global health concern. The commonly reported side effects and resistance mechanisms have imposed the pursuit for new therapeutic alternatives. Moreover, additional preventive strategies shou...
Tong Li,Bowen Wu,Tao Yang et al.
Tong Li et al.
Over the past decades, tumor-resident immune cells have been extensively studied to dissect their biological functions and clinical roles. Tumor-infiltrating CD8+ T cells, because of their cytotoxic and killing ability, have been under the ...
Bing Wen,Li-Yan Xu,En-Min Li
Bing Wen
Lysyl oxidase-like 2 (LOXL2) is a copper and lysine tyrosyl-quinone (LTQ)-dependent amine oxidase belonging to the lysyl oxidase (LOX) family, the canonical function of which is to catalyze the crosslinking of elastin and collagen in the ex...