Christopher A Raab,Monika Raab,Sven Becker et al.
Christopher A Raab et al.
Inhibitors of mitotic protein kinases are currently being developed as non-neurotoxic alternatives of microtubule-targeting agents (taxanes, vinca alkaloids) which provide a substantial survival benefit for patients afflicted with different...
Haidi Chen,Qifeng Zhuo,Zeng Ye et al.
Haidi Chen et al.
Pancreatic cancer is a rapidly progressing disease with a poor prognosis. We still have many questions about the pathogenesis, early diagnosis and precise treatment of this disease. Organoids, a rapidly emerging technology, can simulate the...
The methyltransferase SETD3-mediated histidine methylation: Biological functions and potential implications in cancers [0.03%]
组蛋白修饰甲基转移酶SETD3介导的组蛋白组氨酸甲基化及其生物学功能和潜在的病理学意义
Wen-Jie Shu,Hai-Ning Du
Wen-Jie Shu
SETD3 belongs to a family of SET-domain containing proteins. Recently, SETD3 was found as the first and so-far the only known metazoan histidine methyltransferase that catalyzes actin histidine 73 (His73) methylation, a pervasive modificati...
Sen Yu,Chunyu Zhang,Ke-Ping Xie
Sen Yu
Pancreatic cancer is a lethal disease with limited opportunity for resectable surgery as the first choice for cure due to its late diagnosis and early metastasis. The desmoplastic stroma and cellular genetic or epigenetic alterations of pan...
Altered glycosylation in cancer: A promising target for biomarkers and therapeutics [0.03%]
癌症中糖基化改变的生物标志物和治疗作用及靶点前景展望
Divya Thomas,Ashok Kumar Rathinavel,Prakash Radhakrishnan
Divya Thomas
Glycosylation is a well-regulated cell and microenvironment specific post-translational modification. Several glycosyltransferases and glycosidases orchestrate the addition of defined glycan structures on the proteins and lipids. Recent adv...
The role of CAF derived exosomal microRNAs in the tumour microenvironment of melanoma [0.03%]
CAF源外泌体微环境中miRNA在黑色素瘤肿瘤微环境中的作用
M Shelton,C A Anene,J Nsengimana et al.
M Shelton et al.
Exosomes play a crucial role in the crosstalk between cancer associated fibroblasts (CAFs) and cancer cells, contributing to carcinogenesis and the tumour microenvironment. Recent studies have revealed that CAFs, normal fibroblasts and canc...
Pre-clinical tumor models of primary brain tumors: Challenges and opportunities [0.03%]
原发性脑肿瘤的临床前肿瘤模型：挑战与机遇
Farhana Akter,Brennan Simon,Nadine Leonie de Boer et al.
Farhana Akter et al.
Primary brain tumors are a heterogeneous group of malignancies that originate in cells of the central nervous system. A variety of models tractable for preclinical studies have been developed to recapitulate human brain tumors, allowing us ...
Translational control in the naked mole-rat as a model highly resistant to cancer [0.03%]
作为癌症高度抵抗模型的无毛莫罗鼠体内的翻译控制
Giovanna Maldonado,Greco Hernández
Giovanna Maldonado
Dysregulation of mRNA translation is involved in the onset and progression of different types of cancer. To gain insight into novel genetic strategies to avoid this malady, we reviewed the available genomic, transcriptomic, and proteomic da...
Blood-based PD-L1 analysis in tumor-derived extracellular vesicles: Applications for optimal use of anti-PD-1/PD-L1 axis inhibitors [0.03%]
基于血液的肿瘤源性细胞外囊泡PD-L1分析：抗PD-1 / PD-L1轴抑制剂的最佳应用
Marzia Del Re,Ron H N van Schaik,Stefano Fogli et al.
Marzia Del Re et al.
Monoclonal antibodies that inhibit the programmed cell death protein 1 axis (anti-PD-1/PD-L1) are part of a new pharmacological strategy aimed at reinforcing the immune response to cancer. Despite the success in several cancer types, a sign...
Catríona M Dowling,Hua Zhang,Tríona Ní Chonghaile et al.
Catríona M Dowling et al.
Metabolic reprogramming is a hallmark of cancer which contributes to essential processes required for cell survival, growth, and proliferation. Non-small cell lung cancer (NSCLC) is the most common type of lung cancer and its genomic classi...