Natsuki Furukawa,Aleksander S Popel
Natsuki Furukawa
Cancer immunotherapy has achieved positive clinical outcomes and is revolutionizing cancer treatment. However, cancer immunotherapy has thus far failed to improve outcomes for most "cold tumors", which are characterized by low infiltration ...
The emerging roles of exosomes in anti-cancer drug resistance and tumor progression: An insight towards tumor-microenvironment interaction [0.03%]
外泌体在抗肿瘤药物耐药及肿瘤进展中作用的研究进展：聚焦肿瘤微环境交互作用的新视野
Bikash Chandra Jena,Mahitosh Mandal
Bikash Chandra Jena
The tumor microenvironment (TME) is a complex network of cellular organization consisting of fibroblasts, adipocytes, pericytes, immune cells endothelial cells, and extracellular matrix proteins. Besides communicating with each other, tumor...
Deregulated estrogen receptor signaling and DNA damage response in breast tumorigenesis [0.03%]
乳腺肿瘤发生过程中的雌激素受体信号失调及DNA损伤修复异常机制研究
Arathi Rajan,Revathy Nadhan,Neetha Rajan Latha et al.
Arathi Rajan et al.
Carriers of BRCA1 mutations have a higher chance of developing cancers in hormone-responsive tissues like the breast, ovary and prostate, compared to other tissues. These tumors generally exhibit basal-like characters and do not express est...
Third-line treatment of HER2-positive advanced breast cancer: From no standard to a Pandora's box [0.03%]
HER2阳性晚期乳腺癌三线治疗：从无标准到潘多拉魔盒
Paolo Tarantino,Aleix Prat,Javier Cortes et al.
Paolo Tarantino et al.
Human epidermal growth factor receptor 2 positive (HER2+) advanced breast cancer (ABC) accounts for about 15-20% of all ABC cases. Large randomized trials have determined the standard first- and second-line treatments for this subgroup of p...
Bidirectional and dynamic interaction between the microbiota and therapeutic resistance in pancreatic cancer [0.03%]
胰腺癌微环境与治疗抵抗的相互作用
Jia Dong,He-Li Gao,Wen-Quan Wang et al.
Jia Dong et al.
Pancreatic ductal adenocarcinoma is one of the most lethal malignancies and is known for its high resistance and low response to treatment. Cancer treatments can reshape the microbiota and in turn, the microbiota influences the therapeutic ...
Of immune checkpoint maladies and remedies: The throwing of jabs in the oncogenic ring of PDAC [0.03%]
免疫检查点疾病的治疗现状及对策：PDAC基因环中的 jab 假说
Olamide T Olaoba,Funmilayo C Ligali,Zaccheaus O Alabi et al.
Olamide T Olaoba et al.
The upregulation of co-inhibitory checkpoint receptors/ligands that inactivate antitumor T-cells, the enhancement of Tregs-mediated trogocytosis that contribute delayed maturation of antigen presenting cell (APC), and the high Tregs/CD+8 ra...
Mechanisms of docetaxel resistance in prostate cancer: The key role played by miRNAs [0.03%]
-docetaxel耐药的前列腺癌中miRNA的作用机制研究
Milena Rizzo
Milena Rizzo
One of the main problems with the treatment of metastatic prostate cancer is that, despite an initial positive response, the majority of patients develop resistance and progress. In particular, the resistance to docetaxel, the gold standard...
Designing precision medicine panels for drug refractory cancers targeting cancer stemness traits [0.03%]
针对癌症干细胞特性设计精准医疗药物以治疗难治性癌症
Sudha Warrier,Manasi Patil,Sanyukta Bhansali et al.
Sudha Warrier et al.
Cancer is one amongst the major causes of death today and cancer biology is one of the most well researched fields in medicine. The driving force behind cancer is considered to be a minor subpopulation of cells, the cancer stem cells (CSCs)...
A "hit-and-run" affair - A possible link for cancer progression in virally driven cancers [0.03%]
一次“肇事逃逸”式的事件——病毒驱动的癌症可能与癌细胞进展有关的一点联系
Danyelle A Ferreira,Yaman Tayyar,Adi Idris et al.
Danyelle A Ferreira et al.
Background: It is well-known that certain cancers are caused by viruses. However, viral oncogenesis is complex and only a small fraction of the infected people develop cancer. Indeed, a number of environmental factors can...
New insights into molecular pathways in colorectal cancer: Adiponectin, interleukin-6 and opioid signaling [0.03%]
colorectal cancer中新的分子通路研究:脂联素、白介素-6和阿片受体信号途径的新见解
Mikołaj Świerczyński,Agata Szymaszkiewicz,Jakub Fichna et al.
Mikołaj Świerczyński et al.
Colorectal cancer (CRC) is one of the most common cause of death among neoplasms around the world. The environmental factors, like diet and obesity, are crucial in CRC pathogenesis by creating cancer-favorable microenvironment and hormonal ...