Insight into the multi-faceted role of the SUV family of H3K9 methyltransferases in carcinogenesis and cancer progression [0.03%]
SUV甲基转移酶家族在肿瘤发生发展中的功能研究进展
Nirmalya Saha,Andrew G Muntean
Nirmalya Saha
Growing evidence implicates histone H3 lysine 9 methylation in tumorigenesis. The SUV family of H3K9 methyltransferases, which include G9a, GLP, SETDB1, SETDB2, SUV39H1 and SUV39H2 deposit H3K9me1/2/3 marks at euchromatic and heterochromati...
Power and promise of exosomes as clinical biomarkers and therapeutic vectors for liquid biopsy and cancer control [0.03%]
外泌体作为临床生物标志物和治疗载体在液体活检和癌症控制中的潜力与前景
Yu-Shui Ma,Xiao-Li Yang,Rui Xin et al.
Yu-Shui Ma et al.
Exosomes, microvesicles derived from the nuclear endosome and plasma membrane, can be released into the extracellular environment to act as mediators between the cell membrane and cytoplasmic proteins, lipids, or RNA. Exosomes are considere...
Relationships between DNA repair and RTK-mediated signaling pathways [0.03%]
DNA修复与受体酪氨酸激酶介导的信号转导通路之间的关系
Thomas Chabot,Yvonnick Cheraud,Fabrice Fleury
Thomas Chabot
Receptor Tyrosine Kinases (RTK) are an important family involved in numerous signaling pathways essential for proliferation, cell survival, transcription or cell-cycle regulation. Their role and involvement in cancer cell survival have been...
Effect of probiotics and gut microbiota on anti-cancer drugs: Mechanistic perspectives [0.03%]
益生菌和肠道微生物对抗癌药物的作用：机制展望
Aja Badgeley,Hina Anwar,Karan Modi et al.
Aja Badgeley et al.
Bacteria present in probiotics, particularly the common Lactobacillus and Bifidobacterium microbes, have been found to induce anti-cancer action by enhancing cancer cell apoptosis and protecting against oxidative stress. Probiotics suppleme...
Yu Zhang,Yiqiong Yang,Xiuxiu Hu et al.
Yu Zhang et al.
Protein arginine deiminases (PADs), is a group of calcium-dependent enzymes, which play crucial roles in citrullination, and can catalyze arginine residues into citrulline. This chemical reaction induces citrullinated proteins formation wit...
Yinghui Zhao,Chuanxin Wang,Ajay Goel
Yinghui Zhao
Colorectal cancer (CRC) remains one of the most commonly diagnosed cancers and a leading cause of cancer-related deaths worldwide. The stepwise accumulation of epigenetic alterations in the normal colorectal epithelium has been reported to ...
Shusuke Toden,Timothy J Zumwalt,Ajay Goel
Shusuke Toden
Recent advances have begun to clarify the physiological and pathological roles of non-coding RNAs (ncRNAs) in various diseases, including cancer. Among these, microRNAs (miRNAs) have been the most studied and have emerged as key players tha...
Rhys Gillman,Kylie Lopes Floro,Miriam Wankell et al.
Rhys Gillman et al.
Hepatocellular carcinoma is rapidly becoming a major cause of global mortality due to the ever-increasing prevalence of obesity. DNA damage is known to play an important role in cancer initiation, however DNA repair systems are also vital f...
Lin Zhao,Min Tang,Ann M Bode et al.
Lin Zhao et al.
Adenine nucleotide translocases (ANTs) are a class of transporters located in the inner mitochondrial membrane that not only couple processes of cellular productivity and energy expenditure, but are also involved in the composition of the m...
Xiali Qin,Yu Gu,Tianyu Liu et al.
Xiali Qin et al.
The human gut is mainly habited by a staggering amount and abundance of bacteria as well as fungi. Gut dysbiosis is believed as a pivotal factor in colorectal cancer (CRC) development. Lately increasing evidence from animal or clinical stud...