Sai Shyam Vasantharajan,Michael R Eccles,Euan J Rodger et al.
Sai Shyam Vasantharajan et al.
Cancer metastasis is the main reason for the high mortality in patients, contributing to 90% of cancer-related deaths. Biomarkers for early detection and therapeutic monitoring are essential to improve cancer outcomes. Circulating tumour ce...
The clinical relevance of gene expression based prognostic signatures in colorectal cancer [0.03%]
结直肠癌中基于基因表达的预后标志物的临床意义
Pankaj Ahluwalia,Ravindra Kolhe,Gagandeep K Gahlay
Pankaj Ahluwalia
Colorectal cancer (CRC) is one of the most prevalent cancers, with more than one million new cases every year. In the last few decades, several advancements in therapeutic and preventative levels have reduced the mortality rate, but new bio...
Sharad S Singhal,David Horne,Jyotsana Singhal et al.
Sharad S Singhal et al.
Aberrations in RLIP, p53, and PKCα represent essentially the entire spectrum of all human neoplasms. Elevated PKCα expression, failure of the cell cycle checkpoint (p53 dysfunction), and abnormal glutathione (GSH) metabolism are fundament...
Greco Hernández
Greco Hernández
Diagnostic, prognostic, and therapeutic significance of long non-coding RNA MALAT1 in cancer [0.03%]
长链非编码RNAMALAT1在癌症诊断、预后和治疗中的意义
Bela Goyal,Shashi Ranjan Mani Yadav,Nikee Awasthee et al.
Bela Goyal et al.
Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1) is a widely studied lncRNA in cancer. Although dispensable for normal physiology, MALAT1 is important for cancer-related pathways regulation. It is localized in the nuclear spe...
Roles of CA125 in diagnosis, prediction, and oncogenesis of ovarian cancer [0.03%]
CA125在卵巢癌诊断、预后和肿瘤发生中的作用
Minghai Zhang,Shanshan Cheng,Yue Jin et al.
Minghai Zhang et al.
After it was discovered approximately 40 years ago, carbohydrate antigen 125 (CA125) became the most widely used and concerning biomarker in ovarian cancer screening. However, there is still controversy about its role in clinical practice. ...
Small nucleolar RNA and its potential role in breast cancer - A comprehensive review [0.03%]
小核仁RNA及其在乳腺癌中的潜在作用-全面综述
Venzil Lavie Dsouza,Divya Adiga,S Sriharikrishnaa et al.
Venzil Lavie Dsouza et al.
Small Nucleolar RNAs (snoRNAs) are known for their canonical functions, including ribosome biogenesis and RNA modification. snoRNAs act as endogenous sponges that regulate miRNA expression. Thus, precise snoRNA expression is critical for fi...
Anwar Salem,Mashael Alotaibi,Rima Mroueh et al.
Anwar Salem et al.
The CCR7 chemokine axis is comprised of chemokine ligand 21 (CCL21) and chemokine ligand 19 (CCL19) acting on chemokine receptor 7 (CCR7). This axis plays two important but apparently opposing roles in cancer. On the one hand, this axis is ...
Clusterin as modulator of carcinogenesis: A potential avenue for targeted cancer therapy [0.03%]
clusterin在癌症发生发展中的作用及机制研究重要进展
Prakash Priyadarshi Praharaj,Srimanta Patra,Debasna Pritimanjari Panigrahi et al.
Prakash Priyadarshi Praharaj et al.
Clusterin (CLU) is an evolutionary conserved molecular chaperone present in different human tissues and fluids and established to be a significant cancer regulator. It controls several cancer-associated cellular events, including cancer cel...
Evaluating the current status of protein kinase C (PKC)-protein kinase D (PKD) signalling axis as a novel therapeutic target in ovarian cancer [0.03%]
蛋白激酶C（PKC）-蛋白激酶D（PKD）信号轴在卵巢癌中的作用及作为潜在治疗靶点的价值评估
Komal Tyagi,Adhiraj Roy
Komal Tyagi
Ovarian cancer, especially high grade serous ovarian cancer is one of the most lethal gynaecological malignancies with high relapse rate and patient death. Notwithstanding development of several targeted treatment and immunotherapeutic appr...