You-Min Shen,Fang-Ning Wan,Hua Xu et al.
You-Min Shen et al.
The rapid advancements and declining costs of mRNA technology have led to a significant rise in the use of mRNA-based interventions recently. Unlike traditional drug design schemes, mRNA vaccines rely on next-generation sequencing (NGS) res...
Elucidating cellular origins and TME dynamic evolution in NSCLC through multi-omics technologies [0.03%]
通过多组学技术阐明非小细胞肺癌的细胞起源和肿瘤微环境动态演变
Ning Ning Chao,Li Zhang
Ning Ning Chao
Non-small cell lung cancer (NSCLC) is a leading cause of cancer mortality. Despite progress in targeted therapies and immunotherapy, resistance driven by tumor heterogeneity and dynamic tumor microenvironment (TME) remodeling persists. Mult...
Wenli Liu,Griffin P Rodgers
Wenli Liu
Olfactomedin 4 (OLFM4) is endogenously expressed in several normal human tissues and exerts its biological functions through its diverse binding partners on both the cell surface and intracellularly. OLFM4 is involved in multiple cellular f...
Targeting cholesterol metabolism in tumor and its immune microenvironment: opportunities and challenges [0.03%]
肿瘤及其免疫微环境中的胆固醇代谢调控：机遇与挑战
Ziyi Wang,Xinyan Li,Xiangyu Sun
Ziyi Wang
Cholesterol metabolism provides cell and organelle membrane components, and its precursors and derivatives exert a variety of biological functions. Dysregulated cholesterol metabolism has emerged as a hallmark of tumors. In the tumor microe...
Liquid-liquid phase separation: A dynamic driver of hepatocellular carcinoma [0.03%]
液-液相分离：肝细胞癌的动态驱动因素
Tianle Zhou,Lei Li,Yuping Chen
Tianle Zhou
Liquid-liquid phase separation (LLPS) is a physicochemical phenomenon prevalent in eukaryotic cells, mediating the compartmentalization of discrete subcellular regions through the formation of membrane-less organelles and biomolecular conde...
From infection to immune exhaustion: The Epstein-Barr virus and its contribution to Immunosenescence [0.03%]
从感染到免疫耗竭：EB病毒及其对免疫衰老的贡献
Longtai Hu,Tongxi Zhu,Jingyi Long et al.
Longtai Hu et al.
Epstein-Barr virus (EBV), a common herpesvirus, is linked to chronic infections and malignancies like lymphomas and nasopharyngeal carcinoma. EBV's evasion of immune surveillance and induction of immune dysfunction are critical for disease ...
Baixin Li,Shuang Zhao,Lingling Zhang et al.
Baixin Li et al.
The skin is highly susceptible to external physical stimuli, and mechanical stresses contribute to certain skin tumors. Focusing on keloid, basal cell carcinoma, cutaneous squamous cell carcinoma and melanoma, we systematically examined the...
STIM1-mediated calcium signalling in cancer: Its relation to tumour aggressiveness and therapeutic horizons [0.03%]
STIM1介导的癌症钙信号转导：其与肿瘤侵袭性及治疗靶点的关系
Songling Fang,Yan Wang,Zixian Huang et al.
Songling Fang et al.
Calcium ions (Ca2+), pivotal regulators of tumour progression, drive cancer metastasis and therapy resistance via STIM1-mediated store-operated calcium entry (SOCE). This review focuses on the role of STIM1 and SOCE-mediated calcium signall...
Dan Zhao,Lei Wu,Yongsheng Li
Dan Zhao
In recent years, the interaction between lipid metabolism and immune checkpoint inhibitors (ICIs) has become a key area of research in cancer treatment. Tumor cells utilize lipid metabolism reprogramming to promote rapid proliferation, evad...
Ma Carmen Ocaña,Manuel Bernal,Ana R Quesada et al.
Ma Carmen Ocaña et al.
Angiogenesis and metabolic remodeling are two hallmarks of cancer. This review aims to synthesize the current scientific literature linking these two processes, providing an overview of the principal metabolic mechanisms that contribute to ...