Molecular mechanisms of TAM-regulated tumorigenesis and progression in various types of radiotherapy and future prospects of radiation-immunotherapy combinations [0.03%]
TAM调控的放疗相关肿瘤发生发展的分子机制及其放射免疫联合治疗展望
Luyu Liao,Yuzhao Jin,Wei Mao et al.
Luyu Liao et al.
Although conventional photon radiotherapy can eradicate tumors, the presence of radioresistance has limited treatment efficacy. Nowadays the multiple radiotherapies carried out around different physics beam types will provide more options f...
Role of mesenchymal stem cells in modulating cytokine networks and immune checkpoints in gastric cancer therapy [0.03%]
间充质干细胞在胃癌治疗中调节细胞因子网络和免疫检查点的作用
Zakari Shaibu,Isah Adamu Danbala,Zhihong Chen et al.
Zakari Shaibu et al.
Gastric cancer (GC) remains a leading cause of cancer-related mortality worldwide, driven by a complex tumor microenvironment (TME) that promotes disease progression and therapeutic resistance. This review explores the pivotal roles of mese...
Osteoblasts in bone metastasis: Key players in the tumor microenvironment and therapeutic targets [0.03%]
骨转移中的成骨细胞：肿瘤微环境的关键参与者和治疗靶点
Lingxiao Jin,Zhenxuan Shao,Zhaoming Ye et al.
Lingxiao Jin et al.
Osteoblasts, recognized for their role in bone formation and mineral metabolism, are emerging as pivotal, although underexplored, regulators within the bone tumor microenvironment (TME). Despite increasing evidence of their involvement, the...
Unlocking the power of innate lymphoid cell plasticity in the tumor microenvironment: A revolutionary pathway for cancer immunotherapy [0.03%]
解锁肿瘤微环境内固有淋巴细胞的可塑性潜能：癌症免疫治疗的新路径
Peng Yin,Pei Cao,Yu Liang et al.
Peng Yin et al.
Innate lymphoid cells (ILCs) are emerging as powerful players in the immune system, capable of dramatically influencing tumor immunity. Their extraordinary plasticity, which allows them to adapt to dynamic changes in the tumor microenvironm...
Trogocytosis at crossroads: Navigating the duality in tumor-immune cell interactions [0.03%]
吞噬细胞交叉点：探讨肿瘤免疫细胞相互作用的二元性导航
Xin Yang,Xiaolu Huang,Zhuonan Chen et al.
Xin Yang et al.
Trogocytosis, derived from the Greek "trogo-," meaning "nibble," is a cellular process in which one cell extracts membrane fragments and surface molecules from another, modulating the functions of both donor and recipient cells. In tumor im...
Multidimensional technological advances in cervical cancer screening: From standardized processes to precision medicine [0.03%]
宫颈癌筛查多维度技术进展：从标准化流程到精准医疗
Xiang Li,Jiaxin Zheng,Chang Liu et al.
Xiang Li et al.
Cervical cancer is a common malignancy among women worldwide. To address this significant public health issue, the World Health Organization launched the "Eliminating Cervical Cancer" initiative. Effective screening of cervical cancer is cr...
Targeted drug delivery systems in Lymphoma treatment: Advances and clinical perspectives [0.03%]
靶向药物递送系统在淋巴瘤治疗中的进展与临床前景
Qianqian Guo,Yingshu Luo,Xin Wang et al.
Qianqian Guo et al.
Lymphomas are a heterogeneous group of hematologic tumors that pose a significant challenge in precise treatment. With the development of novel intervention strategies in lymphoma, such as targeted drugs and cell therapy, the prognosis and ...
The dysregulated YY1-EZH2-RKIP axis in cancer cells and immune evasion [0.03%]
癌症细胞中失调的YY1-EHZ2-RKIP轴及其免疫逃逸作用
Talia Festekdjian,Benjamin Bonavida
Talia Festekdjian
We have recently witnessed several milestones in the treatment of a subset of cancer patients with immunotherapy and resulting in significant clinical responses. However, there is a subset that is unresponsive due to resistant factors in th...
Fatty acid addiction in cancer: A high-fat diet directly promotes tumor growth through fatty acid oxidation [0.03%]
脂肪酸与癌症之间的关系：高脂饮食通过促进脂肪酸氧化直接促进肿瘤生长
Soo-Youl Kim
Soo-Youl Kim
Tumor growth promoted by a high-fat diet (HFD) was completely reversed by inhibiting fatty acid oxidation (FAO). The promotion of tumors by an HFD is known to result from the indirect effects of sex hormones, leptin, and adipokines such as ...
Integrating multi-omics proteomic approaches in deciphering the tumor microenvironment and therapeutic resistance mechanisms in prostate cancer [0.03%]
整合多组学蛋白质组方法解码前列腺癌肿瘤微环境及耐药机制
Yutao Wang,Fan Wang,Qi Pan et al.
Yutao Wang et al.
Prostate cancer (PCa) is one of the main causes of cancer-related mortality. The tumor microenvironment (TME) and the development of drug resistance pose significant challenges to effective cancer therapy. This review explores the integrati...