The CD39-CD73-adenosine axis: Master regulator of immune evasion and therapeutic target in pancreatic ductal adenocarcinoma [0.03%]
CD39-CD73-腺苷轴在胰腺导管腺癌中的作用及其作为治疗靶点的潜力：免疫逃避的主要调节者和治疗靶标
Xiaolong Liu,Qingzhu Ding,Han Zhang et al.
Xiaolong Liu et al.
Pancreatic ductal adenocarcinoma (PDAC) exhibits persistent resistance to immunotherapy, with a 5-year survival rate around 10 %. The CD39-CD73-adenosine axis emerges as a critical mediator of immune evasion in PDAC, generating pathological...
The role of protein glycosylation in colorectal cancer: From molecular pathways to clinical applications [0.03%]
结肠直肠癌中蛋白质糖基化的作用：从分子途径到临床应用
Tiangui Wu,Jianguo Gu,Yuhan Sun et al.
Tiangui Wu et al.
Glycosylation, a pivotal post-translational modification, critically influences colorectal cancer (CRC) progression via dysregulated N- and O-linked pathways, characterized by oligomannose, fucosylation, hypersialylation, truncated O-glycan...
Ghazala Rahman,Anamika Bhargava
Ghazala Rahman
Cancer metastasis remains the leading cause of cancer-related deaths, highlighting the urgent need for therapies targeting metastatic processes. Dysregulated calcium (Ca2+) signaling is increasingly linked to metastasis and offers a promisi...
Innate immune cells in oral squamous cell carcinoma: Characteristics and therapeutic potential [0.03%]
口腔鳞状细胞癌中的固有免疫细胞：特征及治疗潜力
Yinjie Jiang,Jingyi Cheng,Jianjun Wu et al.
Yinjie Jiang et al.
Innate immune cells play an important role in the immune system and are mainly responsible for the rapid response to foreign pathogens, damaged tissues, or abnormal cells. However, their immunophenotype in oral squamous cell carcinoma (OSCC...
The role of clonal hematopoiesis of indeterminate potential in non-hematological malignancies of various origins [0.03%]
不确定潜能克隆性造血在各种原发部位的非血液系统恶性肿瘤中的作用
Bo Zheng,Jie He,Wanqian Hu et al.
Bo Zheng et al.
Clonal hematopoiesis of indeterminate potential (CHIP) bridges hematopoietic clonality and solid tumorigenesis, unveiling a systemic dimension of somatic mutagenesis in cancer biology. Generally, population studies demonstrate CHIP carriers...
The evolving landscape of antibody-drug conjugates in small cell lung cancer: From research progress to clinical application [0.03%]
抗体偶联药物在小细胞肺癌中的研究进展与临床应用展望
Haoyu Wang,Chenyue Zhang,Haiyong Wang
Haoyu Wang
Antibody-drug conjugates (ADCs), one of the emerging developing classes of antitumor drugs, have transformed the therapeutic paradigm in oncology. It stands out due to its properties of boasting the strength of both chemotherapy and targete...
Unveiling anaphylatoxins: Pioneering cancer therapies through complement system insights [0.03%]
揭示过敏毒素：通过补体系统的见解开创癌症疗法
Jiamu Li,Xinqiao Li,Jinpeng Hu et al.
Jiamu Li et al.
The complement system, a cornerstone of innate immunity, plays pivotal roles in both defense and pathology, particularly through its anaphylatoxins, C3a and C5a. These small peptides, generated during complement activation, not only mediate...
Cancer stem cells in focus: Deciphering the dynamic functional landscape of stemness in cancer [0.03%]
聚焦癌干细胞：解读癌症干细胞性的动态功能景观
Gabriel C Nwokolo,Trivadi Sundaram Ganesan,Klaus Pors et al.
Gabriel C Nwokolo et al.
Cancer stem cells (CSCs) are central to tumour initiation, progression, and relapse, yet their dynamic and adaptive nature hampers therapeutic targeting. Once viewed as a fixed subpopulation, CSCs are now recognised as a fluid functional st...
Colorectal cancer chemoprevention: Exploring the path from molecular mechanisms to available drugs [0.03%]
结直肠癌化学预防：从分子机制到可用药物的路径探索
Devon M Ivy,Rosa Bordone,Laura Di Magno et al.
Devon M Ivy et al.
Colorectal cancer (CRC) remains a significant global health challenge despite advances in screening and diagnostic modalities that have contributed to reduced incidence and mortality. A substantial proportion of cases, however, continue to ...
Testicular germ cell tumors and infertility: Exploring epigenetic dysregulation in the journey of the male germ cell towards new biomarkers and therapeutics [0.03%]
睾丸生殖细胞肿瘤与男性不育：探索表观遗传失调在男性生殖细胞发育过程中的作用及新的生物标志物和治疗手段的研究旅程
Bruno Oliveira-Lopes,Nuno Tiago Tavares,Rui Henrique et al.
Bruno Oliveira-Lopes et al.
The development of male germ cells comprises a series of differentiation events that culminate in the formation of spermatozoa. From the primordial germ cell (PGC) to the spermatid, an array of epigenetic events take place in different stag...