Revolutionizing bladder cancer research: Harnessing 3D organoid technology to decode tumor heterogeneity and propel personalized therapeutics [0.03%]
革命性膀胱癌研究：利用三维类器官技术解码肿瘤异质性和推动个性化治疗
Helin Kang,Xi Liu,Dan Ge et al.
Helin Kang et al.
Bladder cancer (BC), characterized by remarkable tumor heterogeneity, remains a challenging malignancy with limited therapeutic options. Emerging three-dimensional (3D) organoid models are transforming our understanding of BC biology by clo...
The role of fatty acid oxidation in metabolic crosstalk between tumor cells and associated factors in the microenvironment [0.03%]
脂肪酸氧化在肿瘤细胞与微环境相关因素之间的代谢串扰中的作用
Suman Pakhira,Subhadip Kundu,Sib Sankar Roy
Suman Pakhira
Metabolic reprogramming is a defining characteristic of cancer cells as they undergo multistage development. Cancer cells dynamically adjust their metabolism to aid their survival and to retain their malignant traits within the adverse tumo...
Cancer-associated thrombosis in cholangiocarcinoma: Exploring a phenotype of tumor aggressiveness [0.03%]
肝内胆管癌相关性血栓形成的临床预测因素分析及其作为肿瘤侵袭表型的探索研究
Luca Fabris,Yahima Frión-Herrera,Massimiliano Cadamuro et al.
Luca Fabris et al.
Cholangiocarcinoma (CCA) is the liver malignancy with the most rapid increase in incidence and lethality in recent years. Venous thromboembolism (VTE) is a common complication of the cancer-associated hypercoagulable state, which may incite...
Animal models in preclinical evaluation of CAR-T cell therapy: Advantages and limitations [0.03%]
CAR-T细胞治疗临床前评估的动物模型：优势与局限性
Lasse von Bornemann Fløe,Maya Graham Pedersen,Bjarne K Møller
Lasse von Bornemann Fløe
Chimeric Antigen Receptor T (CAR-T) cell therapy is a promising new treatment category. Animal models have played a pivotal role in advancing CAR-T cell therapy. However, no animal model fully replicates human physiology, leading to unsucce...
Intricate role of DRP1 and associated mitochondrial fission signaling in carcinogenesis and cancer progression [0.03%]
线粒体分裂信号通路关键介质DRP1在肿瘤发生发展中的作用机制研究
Soumya Ranjan Mishra,Priyadarshini Mishra,Prakash Kumar Senapati et al.
Soumya Ranjan Mishra et al.
The process of mitochondrial fission is a major determinant of mitochondrial homeostasis. DRP1 is the chief architect of the mitochondrial fission process, and the DRP1 recruitment to the mitochondrial outer membrane is necessary for the mi...
Functional dichotomy of autophagy signaling in tumor microenvironment driving hallmarks in oral cancer [0.03%]
自噬信号在口腔肿瘤微环境中的功能二元性及其驱动癌症发生的标志性特征
Sushmita Patra,Bishnu Prasad Behera,Birija S Patro et al.
Sushmita Patra et al.
As a cytoprotective mechanism, autophagy recycles damaged proteins and organelles via the lysosomal degradation pathway in response to diverse stress conditions. However, its role in tumor microenvironment, including oral cancer, is still a...
Mechanisms of tumor aggressiveness driven by ablation-induced niche remodeling [0.03%]
肿瘤微环境重塑诱发肿瘤侵袭性的机制研究
Shuyue Gao,Ting Luo,Fangying Fan et al.
Shuyue Gao et al.
Tumor niche represents a dynamic, functionally specialized microenvironment defined by reciprocal interactions between tumor cells and their surrounding stroma. However, emerging evidence suggests that ablation-induced niche remodeling may ...
Unraveling the role of mitochondrial dynamics in cancer stem cells: Molecular basis and therapeutic implications [0.03%]
线粒体动力学在癌症干细胞中的作用：分子基础与治疗意义
Gaia Giannitti,Sara Marchesi,Riccardo Garavaglia et al.
Gaia Giannitti et al.
Many tumors consist of heterogeneous cell populations derived from a minority of cancer stem cells (CSCs), which possess distinct metabolic profiles that contribute to resistance against conventional anticancer therapy and increase the risk...
Hydrogen sulfide and carbon monoxide as possible regulators of YY1 and RKIP: Novel insights into gastrointestinal cancers pathogenesis [0.03%]
氢硫酸化物和一氧化碳可能调节YY1和RKIP：对胃肠道癌症发病机制的新见解
Edyta Korbut,Małgorzata Lasota,Daniel Jankowski et al.
Edyta Korbut et al.
Gastrointestinal (GI) cancers remain among the leading causes of cancer-related mortality, with challenges in early detection, therapeutic resistance, and poor prognosis. Two key molecular players, Yin Yang 1 (YY1) and Raf kinase inhibitor ...
Yogesh Kumar,Lokesh Gambhir,Gaurav Sharma et al.
Yogesh Kumar et al.
Cancer has been one of the primary causes of mortality for the last three decades across the globe, with contemporary treatment modalities often falling short due to limitations viz. drug resistance, toxicity, and the inability to target mo...