Role of macrophage PKM2 in inflammation and tumor progression and its targeted therapy [0.03%]
巨噬细胞PKM2在炎症及肿瘤进展中的作用及其靶向治疗研究进展
Yafei Li,Lingao Zhu,Lu Liu et al.
Yafei Li et al.
Macrophages play a dual role of promoting or inhibiting in inflammation and tumor progression, highly dependent on the dynamic changes of M1/M2 polarization. In inflammation, M1/M2 polarization balance determines the outbreak of inflammatio...
Unstructured but critical: The role of YY1 and YY2 disorder in promoter recognition networks, transcriptional control, and oncogenesis [0.03%]
无序但关键：YY1和YY2在启动子识别网络、转录调控及肿瘤发生中的作用
Małgorzata Figiel,Katarzyna Pustelny,Marta Dziedzicka-Wasylewska et al.
Małgorzata Figiel et al.
The transcription factors Yin Yang 1 and Yin Yang 2 are key regulators of gene expression and play complex roles in cancer development. Although closely related in sequence and structure, YY1 and YY2 differ in their degree of intrinsic diso...
Detection methods for mitochondrial DNA heteroplasmy and their potential single-cell applications in cancer [0.03%]
用于检测线粒体DNA杂合子的方法及其在癌症中的单细胞应用潜力
Tianguang Cheng,Min Pan,Yi Qiao et al.
Tianguang Cheng et al.
Mitochondrial DNA (mtDNA) is crucial for cellular metabolism, oxidative stress responses, and genomic stability, with mutations linked to cancer progression and therapeutic resistance. Mitochondrial heteroplasmy, the coexistence of wild-typ...
Mitochondrial dynamics and metabolic attributes regulate function of natural killer cell and infiltration in tumor microenvironment modulating disease progression [0.03%]
线粒体动态和代谢属性调节自然杀伤细胞的功能及其在肿瘤微环境中的浸润从而调控疾病发展进程
Sayak Ghosh,Rittick Dutta,Devyani Goswami et al.
Sayak Ghosh et al.
Mitochondria in natural killer (NK) cells orchestrate a dynamic interplay between energy production and immune regulation, placing them at the forefront of oncogenesis and tumor microenvironment (TME) infiltration. This review unravels the ...
The role of fatty acid oxidation in the tumor microenvironment: Implications for cancer progression and therapeutic strategies [0.03%]
脂肪酸氧化在肿瘤微环境中的作用：对癌症进展和治疗策略的启示
Nasot Rashed,Wenbin Liu,Xiangjian Luo
Nasot Rashed
Fatty acid oxidation (FAO), or β-oxidation, is a catabolic process that breaks down fatty acids into acetyl-CoA. FAO plays a pivotal role in the metabolic reprogramming of cancer cells and the tumor microenvironment (TME), serving as a cru...
The multifaceted roles of ISG15 in cancer: Conjugated and free forms [0.03%]
ISG15在癌症中的多种作用：共价和非共价形式
Xinran Liu,Qiujin Ma,Zhao Jia et al.
Xinran Liu et al.
Interferon-stimulated gene product 15 (ISG15) is a ubiquitin-like protein. It functions as a conjugated form by covalently modifying target proteins (ISGylation), or in a free form, both are involved in a broad variety of cellular processes...
Lei Yang,Ying Gan,Yu Fan et al.
Lei Yang et al.
Zinc finger proteins (ZNFs), among the most expansive families of transcription factors in eukaryotes, are distinguished by their distinctive zinc-coordinated motifs, which facilitate intricate interactions with DNA, RNA, and other proteins...
The roles and perspectives of YY1 in immune central tolerance establishment [0.03%]
YY1在免疫中枢耐受建立中的作用及机制研究
Gustavo Ulises Martínez-Ruiz,Ricardo Valle-Rios,Marco Velasco-Velazquez et al.
Gustavo Ulises Martínez-Ruiz et al.
Thymic epithelial cells (TEC) drive the proper differentiation of thymocytes for generating self-tolerant naïve T cells. TEC are functionally heterogeneous, as revealed by advancements in single-cell technologies, the development of new mo...
Steroidal derivatives in pancreatic cancer: Paving the way to new anticancer drugs [0.03%]
类固醇衍生物在胰腺癌中的作用：通往新型抗癌药物的道路
Ana R Gomes,Elisiário J Tavares-da-Silva,Fernanda M F Roleira et al.
Ana R Gomes et al.
Pancreatic cancer remains one of the most life-threatening cancers worldwide with limited therapeutic options and a poor prognosis. Despite the advances in treatment regimens, the death rate of pancreatic cancer patients continues to rise, ...
Advancing oncology drug development: Innovative approaches to enhance success rates while reducing animal testing [0.03%]
肿瘤药物开发的创新策略：提高成功率并减少动物实验
Hans Hendriks
Hans Hendriks
Drug development remains a high-risk endeavour, particularly in oncology, where failure rates exceed 90 %. This review examines emerging tools and strategies designed to enhance preclinical success rates, aligning with the 3Rs principle: Re...