The mitochondrial nexus: Targeting metabolic vulnerabilities, oxidative stress, and immunomodulation to induce cancer cell death [0.03%]
线粒体靶点：针对代谢弱点、氧化应激和免疫调控以诱导癌细胞死亡
Woo Hyun Park
Woo Hyun Park
Mitochondria, far from being mere cellular powerhouses, act as central command hubs dictating cell fate by integrating metabolic cues with life-or-death decisions. In cancer, these organelles undergo profound functional and structural repro...
M6A methylation in tumor immune microenvironment: Multidimensional mechanism and targeted therapy strategies [0.03%]
肿瘤免疫微环境中M6A甲基化：多维度机制与靶向治疗策略
Senxu Lu,Junxiu Liu,Shixin Chen et al.
Senxu Lu et al.
N6-methyladenosine (m6A) modification, a dynamic and reversible post-transcriptional RNA alteration, plays a critical role in the precise regulation of gene expression and is fundamentally implicated in the interplay between tumor cells and...
Hyperthermia-induced apoptosis: The role of magnetic nanoparticles in targeted delivery for breast cancer treatment [0.03%]
磁性纳米颗粒在乳腺癌治疗中的作用：靶向输送诱导的高温细胞凋亡研究
Pankaj Garg,Madhu Krishna,David Horne et al.
Pankaj Garg et al.
Magnetochemistry is opening new frontiers in the targeted treatment of breast cancer (BC), offering a precise and innovative way to deliver therapies exactly where they're needed. Beyond drug delivery, magnetic nanoparticles (MNPs) can gene...
AI-powered vaccine breakthroughs: Targeting pancreatic cancer with neoantigens and combination therapies [0.03%]
人工智能助力疫苗突破：用新抗元和组合疗法针对胰腺癌
Jiaxin Zhang,Lin Xiao,Yueshui Zhang et al.
Jiaxin Zhang et al.
The five-year survival rate for Pancreatic Ductal Adenocarcinoma (PDAC) remains below 10 %, primarily due to the limited efficacy of conventional chemotherapy and immune checkpoint inhibitors against its triple-immune-sequestered, low-TMB t...
Advances in tumor micro-environment and immunotherapy of squamous cell carcinoma of the tongue [0.03%]
舌鳞癌肿瘤微环境及免疫治疗进展
Shaopeng Chang,Longhui Li,Yumiao Liu et al.
Shaopeng Chang et al.
Tongue squamous cell carcinoma (TSCC), the most prevalent oral malignancy, demonstrates rising global incidence and mortality rates, while current therapies exhibit limited efficacy in advanced-stage disease. The tumor microenvironment (TME...
Nehal Arvind Kumar,P Manasa,Jaikanth Chandrasekaran
Nehal Arvind Kumar
Uncontrolled cell division is a defining characteristic of cancer, driven by genomic instability. This instability disrupts the DNA damage response network, exacerbates replication stress, and impairs cell cycle checkpoints. Although conven...
Jing Li,Yingkun Yue,Jiaxin Pan et al.
Jing Li et al.
Immune checkpoint inhibitors (ICIs) have demonstrated significant clinical benefits in treating various malignancies. However, their therapeutic efficacy exhibits considerable interindividual variability in patients with colorectal cancer (...
RKIP and tumor immune evasion: Remodeling the immunosuppressive tumor microenvironment [0.03%]
RKIP与肿瘤免疫逃逸：重塑免疫抑制性肿瘤微环境
Evagelia Skouradaki,Giasemi Eptaminitaki,Evagelia Kirio et al.
Evagelia Skouradaki et al.
Raf-1 Kinase Inhibitor Protein (RKIP) is a well-known metastasis suppressor that regulates key oncogenic signaling pathways. Emerging evidence also points to a dual role for RKIP as an immunomodulatory molecule, influencing the tumor immune...
Snake venom-derived peptides as anticancer candidates: Pioneering next-generation therapies [0.03%]
蛇毒衍生的肽作为抗肿瘤候选药物：开创下一代疗法
José R Almeida,Edgar A Pinos-Tamayo,Bruno Mendes et al.
José R Almeida et al.
Cancer treatment has come a long way, but not all cancers can be completely cured. The current therapeutic landscape has significantly reduced mortality rates; however, it remains associated with side effects, limited accessibility, financi...
Dissecting the dual roles of lysosomal membrane proteins: Mediators of autophagy-apoptosis crosstalk in tumor progression [0.03%]
溶酶体膜蛋白在自噬和凋亡交叉 talk 中的双重作用机制及其在肿瘤发生发展中的作用解析
Jiahao Xu,Yujie Jin,Shiqiang Liu et al.
Jiahao Xu et al.
Tumor progression is closely related to the complex interactive regulation between autophagy and apoptosis signaling pathways, particularly the molecular mechanisms mediated by lysosomal membrane proteins (LMPs), and their dynamic regulator...