PAQR4: From spatial regulation of cell signaling to physiological homeostasis and diseases [0.03%]
PAQR4：从细胞信号的空间调节到生理稳态和疾病
Zi-Yan Jin,Zhi-Qiang Ling
Zi-Yan Jin
Progestin and adipoQ receptor family member 4 (PAQR4) gene is a recently discovered seven-transmembrane protein-coding gene that belongs to the PAQR family. An increasing amount of evidence suggests that PAQR4 is upregulated in multiple tum...
Nian Chen,Tao Zhang,Xianyan Yang et al.
Nian Chen et al.
Brain metastasis (BrM) from peripheral solid tumors has a high mortality rate and remains a daunting clinical challenge. In addition to the targeting of tumor cells, studies have focused on the regulation of the tumor microenvironment (TME)...
Tertiary lymphoid structures achieve 'cold' to 'hot' transition by remodeling the cold tumor microenvironment [0.03%]
三级淋巴器官通过重塑“冷”肿瘤微环境实现从“冷”到“热”的转变
Mengke Cui,Mengfan Zhou,Lu Zhou et al.
Mengke Cui et al.
Immune checkpoint blockade (ICB) therapies have demonstrated significant clinical efficacy in immune-infiltrated tumors such as melanoma and non-small cell lung cancer. However, "cold tumors"-including ovarian cancer, pancreatic cancer, and...
Sorafenib resistance and therapeutic strategies in hepatocellular carcinoma [0.03%]
索拉非尼耐药及肝细胞癌的治疗策略
Weijing Zhang,Xuechuan Hong,Yuling Xiao et al.
Weijing Zhang et al.
Hepatocellular carcinoma (HCC) remains one of the most prevalent and lethal cancers globally. While surgical resection and liver transplantation offer potential cures for early-stage HCC, the majority of patients are diagnosed at advanced s...
The crosstalk within tumor microenvironment and exosomes in pancreatic cancer [0.03%]
肿瘤微环境与胰腺癌的外泌体之间的相互作用
Michael Ochieng&#x; Otieno,Tomasz Powrózek,Jesus Garcia-Foncillas et al.
Michael Ochieng&#x; Otieno et al.
Pancreatic cancer is one of the most malignant tumors with a grim prognosis. Patients develop chemoresistance that drastically decreases their survival. The chemoresistance is mainly attributed to deficient vascularization of the tumor, int...
The epipliancy journey: Tumor initiation at the mercy of identity crisis and epigenetic drift [0.03%]
上皮去分化之旅：肿瘤发生是身份危机和表观遗传漂变的产物
Rahma Benhassoun,Anne-Pierre Morel,Victoria Jacquot et al.
Rahma Benhassoun et al.
Cellular pliancy refers to the unique disposition of different stages of cellular differentiation to transform when exposed to specific oncogenic insults. This concept highlights a strong interconnection between cellular identity and tumori...
Unraveling the kinase code: Role of protein kinase in lung cancer pathogenesis and therapeutic strategies [0.03%]
解读激酶密码：蛋白激酶在肺癌发病机制和治疗策略中的作用
Mariyam Fatma,Sana Parveen,Snober S Mir
Mariyam Fatma
Lung cancer is a prominent cause of cancer-related deaths globally, prompting exploration into the molecular pathways governing cancer cell signaling. Recent insights highlight the critical role of kinases in carcinogenesis and metastasis, ...
Some unanswered questions about the pyrimidine catabolic pathway: The human macrophage perspective [0.03%]
嘧啶分解代谢途径的一些未解问题：人类巨噬细胞的角度
Arnaud Millet
Arnaud Millet
Pyrimidine catabolism has attracted attention in relation to pyrimidine analogs used as anticancer drugs but the absence of a severe phenotype associated with pyrimidine catabolism byproducts did not favor to pursue these efforts. Recently,...
Decoding the genetic puzzle: Mutations in key driver genes of pancreatic neuroendocrine tumors [0.03%]
解码基因密码：胰腺神经内分泌肿瘤关键驱动基因的突变
Huanchang Jiang,Wuhu Zhang,Xiaowu Xu et al.
Huanchang Jiang et al.
Although pancreatic neuroendocrine tumors (PanNETs) are less common than other pancreatic tumors, they show significant differences in clinical behavior, genetics, and treatment responses. The understanding of the molecular pathways of PanN...
The role and application of Coronin family in human tumorigenesis and immunomodulation [0.03%]
Coronin家族蛋白在人类肿瘤发生和免疫调节中的作用与应用
Huimeng Gao,Fuli Sun,Xuanyu Zhang et al.
Huimeng Gao et al.
The Coronin family, a class of actin-binding proteins involved in the formation and maintenance of cytoskeleton structural stability, is aberrantly expressed in various tumors, including lung, gastric and head and neck cancers. They can reg...