Fenfang Gui,Limei Zhang,Jiahai Xiao et al.
Fenfang Gui et al.
Intratumoral microbiota are increasingly recognized for their impact on gastric cancer, with growing evidence highlighting their complexity and significance. This review synthesizes current knowledge on the origins, heterogeneity, detection...
Mateusz Wawro,Jakub Kochan,Aneta Kasza
Mateusz Wawro
Transcript turnover, a fundamental process in maintaining cellular homeostasis, involves intricate interactions between cis-acting sequences and trans-acting factors. Recent advancements in RNA decay research have illuminated novel ribonucl...
Nervous system in hepatocellular carcinoma: Correlation, mechanisms, therapeutic implications, and future perspectives [0.03%]
肝细胞癌中的神经系统：相关性、机制、治疗意义及未来展望
Wenxuan Li,Jinghao Zhang,Yueqiu Gao et al.
Wenxuan Li et al.
Hepatocellular carcinoma (HCC) is a highly heterogeneous and complex cancer influenced by both the tumor microenvironment and multi-level regulation of the nervous system. Increasing evidence highlights critical roles of the central nervous...
Tumor immune microenvironment remodeling after neoadjuvant therapy in gastric cancer: Update and new challenges [0.03%]
胃癌新辅助治疗后肿瘤免疫微环境重塑的更新与挑战
Fujing Sun,Xiaozhuo Gao,Tianming Li et al.
Fujing Sun et al.
Gastric cancer (GC) is a malignant tumor with one of the highest morbidity and death rates in the world. Neoadjuvant therapy, including neoadjuvant chemotherapy (NAC) and NAC combined with immunotherapy, can improve the resection and long-t...
VISTA as a context-dependent immune checkpoint: Implications for tumor immunity and autoimmune pathogenesis [0.03%]
VISTA作为一个依赖于环境的免疫检查点：对肿瘤免疫和自身免疫发病机制的意义
Xiaoshuang Niu,Beibei Li,Feiyu Luo et al.
Xiaoshuang Niu et al.
The V-domain Ig suppressor of T cell activation (VISTA) is a recently characterized immune checkpoint regulator with critical roles in modulating immune responses across pathological contexts. In cancer, VISTA contributes to immune evasion ...
CCL20-CCR6 signaling in tumor microenvironment: Functional roles, mechanisms, and immunotherapy targeting [0.03%]
肿瘤微环境中的CCL20-CCR6信号通路：功能、机制及免疫治疗靶向性
Qi Liu,Mingyuan Song,Yan Wang et al.
Qi Liu et al.
Chemokine CC motif ligand 20 (CCL20) is a molecule with immunomodulatory properties that is involved in the regulation of diseases such as chronic inflammation, autoimmune diseases, and cancer. It operates by binding to its specific recepto...
Interactions between cancer cells and tumor-associated macrophages in tumor microenvironment [0.03%]
肿瘤微环境中癌细胞与肿瘤相关巨噬细胞的相互作用
Lu Liu,Yafei Li,Bo Li
Lu Liu
Tumor microenvironment (TME) refers to the local environment in which various cancer cells grow, encompassing tumor cells, adjacent non-tumor cells, and associated non-cellular elements, all of which collectively promote cancer occurrence a...
Targeting the kynurenine pathway in gliomas: Insights into pathogenesis, therapeutic targets, and clinical advances [0.03%]
胶质瘤中靶向犬尿酸途径的研究：发病机制、治疗目标和临床进展的见解
Mikolaj Marek Krupa,Tomasz Pienkowski,Anna Tankiewicz-Kwedlo et al.
Mikolaj Marek Krupa et al.
Gliomas, the most prevalent primary brain tumors, continue to present significant challenges in oncology due to poor patient prognosis despite advances in treatment such as immunotherapy and cancer vaccines. Recent research highlights the p...
Advances in BRAF mutated colorectal cancer-could deoxycholic acid be the culprit? [0.03%]
BRAF突变型结直肠癌的研究进展——脱氧胆酸会是“幕后黑手”吗？
Binle Tian,Xia Xin,Qi Li et al.
Binle Tian et al.
BRAF mutated colorectal cancer (CRC) often demonstrates distinct molecular profiles characterized by a high methylator phenotype with two different microsatellite statuses (MSI and MSS) and corresponding methylation spectra. Prognostic disp...
mTOR inhibitors in targeting autophagy and autophagy-associated signaling for cancer cell death and therapy [0.03%]
靶向自噬和与自噬相关信号转导诱导癌细胞死亡的雷帕霉素哺乳动物靶点抑制剂研究进展
Prakash Kumar Senapati,Kewal Kumar Mahapatra,Amruta Singh et al.
Prakash Kumar Senapati et al.
The mechanistic target of rapamycin (mTOR) is a protein kinase that plays a central regulatory switch to control multifaceted cellular processes, including autophagy. As a nutrient sensor, mTOR inhibits autophagy by phosphorylating and inac...