Spatiotemporal dynamics of the pre-metastatic niche: remodeling of lung microenvironment before breast cancer metastasis and targeted intervention strategies [0.03%]
乳腺癌转移前肺微环境的重塑及干预策略研究
Xinjie Chang,Yan Yao,Minpu Zhang et al.
Xinjie Chang et al.
Breast cancer lung metastasis has attracted considerable research attention because of its complex molecular heterogeneity and refractory characteristics. Development of the pre-metastatic niche (PMN) is a key initiating event in the cancer...
Raf kinase inhibitor protein modulator of gut microbiota and immunotherapy responses in cancer [0.03%]
raf激酶抑制蛋白调节肠道微生物群和癌症免疫治疗反应
Giuseppe Palma,Francesca Bruzzese,Concetta Meo et al.
Giuseppe Palma et al.
Cancer progression and the therapeutic efficacy of targeted treatments are increasingly recognized to be influenced by the gut microbiota (GM). This is particularly evident in the context of immunotherapies, as the composition of the GM can...
Role of Yin Yang 1 (YY1) on microenvironment, signaling pathways, and epigenetics in lung cancer [0.03%]
Yin Yang 1（YY1）在肺癌微环境、信号通路及表观遗传学中的作用
Seema Kumari,S P D Ponamgi,Prashen Chelikani et al.
Seema Kumari et al.
Lung cancer is a significant health concern worldwide. It is caused by smoking and exposure to carcinogens, although other factors like genetics, epigenetics, and transcription factors also play a role. Yin Yang 1 (YY1) is a transcription f...
The roles and mechanisms of non-canonical RNA secondary structures in tumors [0.03%]
非经典RNA二级结构在肿瘤中的作用和机制
Ziyi Pan,Zhaoyang Zeng,Wei Xiong et al.
Ziyi Pan et al.
In recent years, significant breakthroughs have been achieved in the study of RNA secondary structures. The roles of canonical structures, such as hairpins, internal loops, and stem-loops, in gene expression regulation, genome stability, an...
Le Zhang,Xiujuan Chen,Yanbing Zhang et al.
Le Zhang et al.
Gynecological cancers are cancers that begin in the female reproductive organs. Gynecological cancer is the second most common cancer type among women and has become a global health burden for the female population. More than 50 % of all gy...
Yi-Min Chen,Lin Chen,Yu-Xin Xu et al.
Yi-Min Chen et al.
Globally, prostate cancer (PCa) ranks as one of the most frequent malignant tumors in men, with metastasis and drug resistance significantly impacting clinical outcomes. Traditionally, cancer metastasis and drug resistance were regarded as ...
Epigenetic mechanisms in non-small cell lung cancer therapy and chemoresistance [0.03%]
表观遗传机制在非小细胞肺癌治疗和化疗耐药中的作用
Ying Xu,Yang Meng,Yongfeng Xu et al.
Ying Xu et al.
Epigenetic mechanisms play a crucial role in cancer development and progression, encompassing DNA methylation, chromatin organization, histone modifications, and noncoding RNA regulation. Lung cancer is a major cause of cancer-related death...
Giulia Zerbo,Daniela Gasparotto
Giulia Zerbo
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal malignancies of the digestive tract. About 85 % of them have gain-of-function mutations in KIT or PDGFRA, resulting in constitutive activation of these receptor tyrosin...
Experimental toolkit to study the oncogenic role of WNT signaling in colorectal cancer [0.03%]
用于研究WNT信号在结直肠癌致癌作用的实验工具包
Pujarini Dash,Vikas Yadav,Biswajit Das et al.
Pujarini Dash et al.
Colorectal cancer (CRC) is linked to the WNT/β-catenin signaling as its primary driver. Aberrant activation of WNT/β-catenin signaling is closely correlated with increased incidence, malignancy, poorer prognosis, and even higher cancer-re...
Breaking the immune desert: Strategies for overcoming the immunological challenges of pancreatic cancer [0.03%]
打破免疫荒漠：克服胰腺癌免疫学挑战的策略
Tianming Wang,Wenjing Song,Yuan Tang et al.
Tianming Wang et al.
Pancreatic cancer is characterised by its highly aggressive nature and extremely poor prognosis, with a uniquely complex tumour immune microenvironment that manifests as a prototypical "immune desert." This immune-desert phenotype primarily...