Exploring synthetic lethality in cancer therapy: CRISPR-Cas9 technology offers new hope [0.03%]
合成致死性在癌症治疗中的探索——CRISPR-Cas9技术带来新希望
Yuqi Wu,Yali Wang,Yanbin Wang et al.
Yuqi Wu et al.
Synthetic lethality (SL) is a breakthrough concept in cancer therapy that describes a scenario in which the simultaneous inactivation of two genes leads to cell death, whereas inactivation of either gene alone does not. The rise of clustere...
Autophagy-related myosins: Critical roles and potential therapeutic effects in malignancies [0.03%]
自噬相关肌球蛋白：在恶性肿瘤中的关键作用及潜在治疗效应
Jiaying Xiong,Xin Wen,Meiyan Chen et al.
Jiaying Xiong et al.
Myosins, a superfamily of actin-based molecular motor proteins, are important regulators of actin cytoskeleton structure and remodeling. They act as mechano-sensors of the tumor environment, controlling key cellular processes associated wit...
Fan Gao,Kang Sun,Sicheng Wang et al.
Fan Gao et al.
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers. During tumor progression, metabolic reprogramming plays a crucial role in both tumor proliferation and immune evasion. In PDAC, genetic mutations and environment lim...
Unveiling the TGF-β/Smad signaling in renal carcinoma progression: Prognostic and therapeutic insights [0.03%]
肾癌进展中TGF-β/Smad信号通路的揭秘：预后和治疗启示
Vânia Dias,Ângela Alves,Rui Medeiros et al.
Vânia Dias et al.
About 2 to 3 % of all new cancer cases worldwide are renal carcinomas. Nevertheless, during the past few decades, there has been a 2 % annual increase in the prevalence of this malignancy worldwide. Within three years, 20 to 40 % of individ...
The NLRP3 inflammasome and its role in acute myeloid leukemia onset and development [0.03%]
NLRP3炎性小体在急性髓系白血病发生发展中的作用研究
Brunno Gilberto Santos de Macedo,Manuela Albuquerque de Melo,Diego Antonio Pereira-Martins et al.
Brunno Gilberto Santos de Macedo et al.
The tumor microenvironment plays an important role in cancer onset and progression. Its significance has been increasingly addressed in myeloid neoplasms. Such a shift marks a departure from the usual tumor-centered approach to a more compr...
Samu John,Dhanya Kalathil,Ramesh Pothuraju et al.
Samu John et al.
E26 Transformation-Specific homolog 2 (ETS2) is a founding member of the ETS family of transcription factors and has been implicated in several developmental and survival functions. The predominant route of its action is by directly binding...
Sequencing of antibody drug conjugates in breast cancer: Evidence gap and future directions [0.03%]
抗体偶联药物在乳腺癌中的应用：证据缺口及未来方向
Renata Pacholczak-Madej,Małgorzata Meluch,Mirosława Püsküllüoğlu
Renata Pacholczak-Madej
Antibody-drug conjugates (ADCs) have transformed breast cancer treatment by enabling the targeted delivery of cytotoxic agents. However, the optimal sequencing of ADCs remains undefined, with factors such as target antigen, linker type, and...
miRNA expression based modulation: A new paradigm for the treatment of chronic myeloid leukemia [0.03%]
基于微小核糖核酸表达的调节：慢性髓性白血病治疗的新模式
Sana Ansari,Malkhey Verma
Sana Ansari
MicroRNAs (miRNAs) are non-coding and internally derived small RNA molecules. They post-transcriptionally direct gene expression either by inhibiting translation or initiating degradation of mRNA. Conserved evolutionarily, these miRNAs have...
Unraveling metastatic timing: insights and challenges from genomic evolution [0.03%]
解开转移性肿瘤的时序：来自基因组进化的一些见解和挑战
Qiu-Luo Liu,Zong-Guang Zhou,Ziqiang Wang et al.
Qiu-Luo Liu et al.
Metastasis, a significant hurdle in cancer treatment, is driven by genetic alterations that shape tumor evolution and dissemination. Traditionally viewed as a late-stage event, recent evidence suggests that metastasis may initiate earlier i...
The enzyme glycogen synthase kinase-3 is associated with specific forms oncogenesis; what more do we need to know to achieve clinical benefit? [0.03%]
糖原合成酶激酶-3与特定形式的肿瘤发生相关；我们还需要了解哪些内容才能获得临床益处？
Calum Sutherland,Ruby Harrower,Josh T Coats et al.
Calum Sutherland et al.
Mutations in glycogen synthase kinase-3 (GSK3) are associated with oncogenesis, but the opposing roles of GSK3 in tumour suppression and promotion, inadequate methods for assessing GSK3 activity and off-target effects of commonly used inhib...