Targeting the YY1-Bcl2-c-Myc Axis in the treatment of non-Hodgkin lymphoma [0.03%]
靶向YY1-Bcl2-c-Myc轴治疗非霍奇金淋巴瘤
Mai P Ho,Evagelia Skouradaki,Stavroula Baritaki et al.
Mai P Ho et al.
Non-Hodgkin lymphoma (NHL) presents a complex therapeutic challenge due to its heterogeneous nature and the high incidence of relapse following initial treatment. As such, patients who are more susceptible to treatment resistance face a poo...
TXNIP in cancer: Unlocking biological insights and tackling clinical challenges [0.03%]
TXNIP在癌症中的作用：揭示生物学新知和应对临床挑战
Piercarlo Del Console,Luca Gelsomino,Cinzia Giordano et al.
Piercarlo Del Console et al.
Cancer remains a major global health challenge and one of the leading causes of mortality worldwide. Its development and progression involve complex genetic and molecular alterations, including the activation of oncogenes, as well as the in...
Targeting hormone-related signals to reprogram the antitumor immune response in breast cancer: Research progress and application prospects [0.03%]
靶向激素相关信号重编程乳腺癌抗肿瘤免疫应答的研究进展及应用前景
Shunchao Yan,Zhijie Zhang,Jiale Ji et al.
Shunchao Yan et al.
Breast cancer is a heterogeneous disease with varying responses to hormonal therapies and immunotherapies. It is commonly characterized as a "cold" tumor; however, increasing evidence demonstrates the immunomodulatory effects of hormonal si...
Longyu Liu,Zhiyao Fan,Hanxiang Zhan
Longyu Liu
Pancreatic cystic lesions (PCLs) represent a highly heterogeneous category of pancreatic abnormalities with an increasing prevalence due to advances in imaging modalities and an aging population. While the majority of PCLs are benign, a sub...
Yin yang 1: a potential regulator of immune related diseases and cancer immunity [0.03%]
阴阳离子1：免疫相关疾病和癌症免疫的潜在调节因子
Yutong Tan,Dan Ye,Cheng Qian et al.
Yutong Tan et al.
Yin Yang (YY1) is a context-dependent bifunctional transcription factor, activating or repressing target gene transcription via transcriptional or post-translational way, participate in multiple physiological processes including development...
Advances in the combination of immunoadjuvants and tumor ablation: Mediating immune effects to enhance anti-tumor efficacy [0.03%]
免疫佐剂与肿瘤消融联合应用的研究进展：介导免疫效应增强抗肿瘤疗效
Duo Yu,Yang Zuo,Mengdi Qi et al.
Duo Yu et al.
Percutaneous tumor ablation is a minimally invasive treatment for tumors. The release of tumor neoantigens after ablation not only remodels the local tumor microenvironment, but also achieves abscopal effects by mediating local and systemic...
Raf-kinase inhibitor protein (RKIP): A therapeutic target in colon cancer [0.03%]
Raf激酶抑制蛋白(RKIP)在结肠癌治疗中的作用与机制研究
Seema Kumari,Sujatha Peela,Pallaval Veera Bramhachari et al.
Seema Kumari et al.
Raf-kinase inhibitor protein (RKIP) plays a significant role in maintaining cell homeostasis, and its downregulation is a hallmark of various cancers, including colorectal cancer (CRC). It modulates several signals, including MAPK (Raf/MEK/...
Navigating circulating tumour cells and tumour microemboli: Where we stand in bridging their molecular dynamics with clinical translation [0.03%]
循环肿瘤细胞和肿瘤微栓子的研究现状：阐明其分子动力学并实现临床转化
Deepa Bisht,Vivek Kumar,Sudha Gupta et al.
Deepa Bisht et al.
Circulating tumour cells (CTCs) and circulating tumour microemboli (CTM) are key liquid biopsy biomarkers that reflect tumour invasiveness and metastatic potential. CTM, compared to single CTCs, exhibit greater heterogeneity, epithelial-mes...
Key subunits of γ-secretase complex and breast cancer progression: biological function, regulation mode and therapeutic potential [0.03%]
γ分泌酶复合物的关键亚基与乳腺癌进展：生物学功能、调控模式及治疗潜力
Ran Xu,Xin Yang,Kuo Yao et al.
Ran Xu et al.
Breast cancer (BC) is the most prevalent malignant tumor among females. The primary therapeutic options currently available include surgery, radiotherapy, chemotherapy, targeted therapy, and immunotherapy. However, the emergence of drug res...
Targeting the triad: phenotypic plasticity, tumor microenvironment and bone microenvironment in prostate cancer bone-metastatic events [0.03%]
前列腺癌骨转移中的表型可塑性、肿瘤微环境和骨微环境
Ma Chi-Cheng,Ou-Yang Ao-Rong,Chen Zi-Xian et al.
Ma Chi-Cheng et al.
The incidence and mortality rates of prostate cancer are increasing annually, indicating that it poses a serious threat to men's health. Previous studies have demonstrated that bone-metastatic tumor cells undergo four hallmark bone-metastat...