Gluconeogenesis in cancer cells - Repurposing of a starvation-induced metabolic pathway? [0.03%]
癌症细胞中的糖异生——饥饿诱导代谢途径的再利用？
Gabriele Grasmann,Elisabeth Smolle,Horst Olschewski et al.
Gabriele Grasmann et al.
Cancer cells constantly face a fluctuating nutrient supply and interference with adaptive responses might be an effective therapeutic approach. It has been discovered that in the absence of glucose, cancer cells can synthesize crucial metab...
Karolina Elżbieta Kaczor-Urbanowicz,Fang Wei,Shannon Liu Rao et al.
Karolina Elżbieta Kaczor-Urbanowicz et al.
Cancer, a local disease at an early stage, systemically evolves as it progresses by triggering alterations in surrounding microenvironment, disturbing immune surveillance and further disseminating its molecular contents into circulation. Th...
Meng Sha,Jie Cao,Han-Yong Sun et al.
Meng Sha et al.
Increasing studies have demonstrated that neuroendocrine system is involved in the development and progression of cholangiocarcinoma. The neuroendocrine hormones, neurotransmitters and neuropeptides regulate cholangiocarcinoma via affecting...
Defective mitosis-linked DNA damage response and chromosomal instability in liver cancer [0.03%]
肝癌中的缺陷有丝分裂相关DNA损伤应答和染色体不稳定性
Maryam Tahmasebi-Birgani,Hossein Ansari,Vinicio Carloni
Maryam Tahmasebi-Birgani
Hepatocellular carcinoma (HCC), the most common form of liver cancer, represents a health problem in hepatic viruses-eradicating era because obesity, type 2 diabetes, and nonalcoholic steatohepatitis (NASH) are considered emerging pathogeni...
Corrigendum to Preclinical models for precision oncology. BBACAN 1870/2 (2018) 239-246 [0.03%]
精准肿瘤学的临床前模型订正说明(BBACAN 1870/2 (2018) 239-246)
Maider Ibarrola-Villava,Andrés Cervantes,Alberto Bardelli
Maider Ibarrola-Villava
Achalasia and associated esophageal cancer risk: What lessons can we learn from the molecular analysis of Barrett's-associated adenocarcinoma? [0.03%]
achalasia与相关食管癌风险：我们能从Barrett氏病相关腺癌的分子分析中得到哪些教训？
K Nesteruk,M C W Spaander,I Leeuwenburgh et al.
K Nesteruk et al.
Idiopathic achalasia and Barrett's esophagus (BE) are preneoplastic conditions of the esophagus. BE increases the risk of esophageal adenocarcinoma (EAC), while achalasia is associated with both EAC and esophageal squamous cell carcinoma (E...
The role of pyroptosis in gastrointestinal cancer and immune responses to intestinal microbial infection [0.03%]
焦亡在胃肠道癌症及对肠道微生物感染的免疫反应中的作用
Cheng-Bei Zhou,Jing-Yuan Fang
Cheng-Bei Zhou
Pyroptosis, a type of inflammatory programmed cell death, is mediated by multiple inflammasomes which can recognize danger signals and activate the secretion of pro-inflammatory cytokines like IL-181 and IL-1β2. It can induce cancer cell d...
Lin Zhang,Dihua Yu
Lin Zhang
Exosomes play essential roles in intercellular communications. The exosome was discovered in 1983, when it was found that reticulocytes release 50-nm small vesicles carrying transferrin receptors into the extracellular space. Since then, ou...
Piumi Y Liyanage,Sajini D Hettiarachchi,Yiqun Zhou et al.
Piumi Y Liyanage et al.
Breast cancer (BC) is the most common malignancy in women worldwide, and one of the deadliest after lung cancer. Currently, standard methods for cancer therapy including BC are surgery followed by chemotherapy or radiotherapy. However, both...
Drug repurposing in oncology: Compounds, pathways, phenotypes and computational approaches for colorectal cancer [0.03%]
抗癌药物再利用：结直肠癌的化合物、途径、表型和计算方法
Patrycja Nowak-Sliwinska,Leonardo Scapozza,Ariel Ruiz i Altaba
Patrycja Nowak-Sliwinska
The strategy of using existing drugs originally developed for one disease to treat other indications has found success across medical fields. Such drug repurposing promises faster access of drugs to patients while reducing costs in the long...