Decoding the key hallmarks of chemoresistance: A proteomic tale from breast cancer research [0.03%]
解读化学抗性关键特征：来自乳腺癌研究的蛋白质组学故事
Praneeta Pradip Bhavsar,Bhargab Kalita,Khushman Taunk et al.
Praneeta Pradip Bhavsar et al.
Chemoresistance denotes the intricate, multifactorial molecular mechanisms by which malignant cells subvert the cytotoxicity of chemotherapeutic agents, thereby impeding therapeutic efficacy. This phenomenon is orchestrated through a conflu...
Dan Deng,Yan Luo,Yun Hong et al.
Dan Deng et al.
Lactate, a central metabolite generated during glycolysis, functions not only as a by-product but also as a critical signalling mediator, profoundly influencing tumor progression and cellular destiny. Among the post-translational modificati...
Taurine and cancer: Biological properties and multifaceted roles in cancer progression [0.03%]
牛磺酸与癌症：生物学特性及在癌症进展中的多面作用
Rong Liu,Xinze Li,Zhenyu Hua et al.
Rong Liu et al.
Cancer remains one of the leading causes of mortality worldwide and poses a major threat to global health. Recent insights into the tumor microenvironment (TME) have highlighted the pivotal role of amino acid metabolism-one of the three cor...
Anoikis and NETosis in colorectal cancer liver metastasis: the relationship and perspectives [0.03%]
anoikis 和NETosis在结直肠癌肝转移中的关系及展望
Ruoyu Zhang,Yunfei Tan,Dedi Jiang et al.
Ruoyu Zhang et al.
Colorectal cancer (CRC) is a leading cause of cancer-related mortality, with metastatic spread being the primary reason for fatalities. Anoikis, a form of programmed cell death triggered by cell detachment from the extracellular matrix (ECM...
Xinyi Zhou,Yujia Song,Zhen Wang et al.
Xinyi Zhou et al.
Cancer constitutes a significant global health challenge, with altered metabolism being a hallmark feature of cancer cells. Diet can directly modulate systemic metabolite levels, thereby exerting both direct and indirect influences on tumor...
Mechanism of interleukin-6 cytokine family in bone metastasis of lung cancer and prospects for its application [0.03%]
肺癌骨转移中白细胞介素-6细胞因子家族的作用机制及应用前景展望
Jinbai Huang,Qingting Zhang,Yuanshan Yang et al.
Jinbai Huang et al.
Bone metastasis is a significant clinical problem for lung cancer patients. Current studies have reported a strong relationship between the progression of bone metastases from lung cancer and inflammatory cytokines, which can modulate the t...
Research advances on amino acid starvation interventions for hepatocellular carcinoma [0.03%]
氨基酸剥夺在肝细胞癌治疗中的研究进展
Yanqi Li,Lin Li,Yongyong Hou et al.
Yanqi Li et al.
Hepatocellular carcinoma (HCC) is an aggressive malignancy associated with high mortality. Numerous endeavors have been undertaken to develop more effective pharmaceutical interventions. Metabolic reprogramming is recognized as a hallmark o...
Multidimensional regulation of the microbe-TLR4 signaling Axis in colorectal cancer: From molecular mechanisms to microbe-targeted therapies [0.03%]
肠癌中微生物TLR4信号轴的多维度调控：从分子机制到微生物靶向治疗
Caihou Zhang,Haimin Geng,Yurong Tan et al.
Caihou Zhang et al.
Colorectal cancer (CRC), the third most common cancer globally, arises from complex interactions between genetic predisposition, environmental factors, and gut microbiota dysbiosis. This review systematically analyzes the multidimensional r...
Metabolic reprogramming in breast cancer: Pathways driving progression, drug resistance, and emerging therapeutics [0.03%]
乳腺癌中的代谢重构：促进进展、耐药和新兴疗法的途径
Pankaj Garg,Gargi Singhal,David Horne et al.
Pankaj Garg et al.
Breast cancer (BC), one of the most frequent causes of cancer-related death in women, is known to be a highly heterogeneous disease in regard to molecular subtypes, which seem to possess different metabolic profiles. Aberrant metabolism is ...
From unearthing to an intriguing cancer-fighting target: the human BCL-2 promoter G-quadruplex and i-motif [0.03%]
从发现到有吸引力的抗癌靶点：人类Bcl-2启动子G-四链体和i- motif
Pronamika Chetia,Amit Kumar
Pronamika Chetia
Cancer is a global burden that calls for creative solutions. Among the several hallmarks of cancer, overexpression of the BCL-2 oncogene serves as a factor for cancer cell proliferation and progression. Targeting the transcription machinery...