Evaluation of patient experiences with a structured home treatment pathway for pulmonary embolism using direct oral anticoagulants [0.03%]
直接口服抗凝药治疗肺栓塞的结构化家庭治疗路径患者的体验评估
Sophie N M Ter Haar,Jeroen C J Eikenboom,Paul L den Exter et al.
Sophie N M Ter Haar et al.
Background: Patients with pulmonary embolism (PE) at low-risk for early PE-related complications can be treated safely at home. Patient satisfaction with such treatment has hardly been investigated. ...
Analytical and clinical validation of the Tsmart FIB Batrox© assay on the LabPad Evolution analyzer for fibrinogen measurement in whole blood [0.03%]
LabPad Evolution分析仪上用于全血纤维蛋白原测定的Tsmart FIB Batrox©检测的分析和临床验证
Nina Breteau,Corinne Frère,Raphaël Marlu et al.
Nina Breteau et al.
Background: Fibrinogen is the first coagulation factor to drop during severe hemorrhage, making it an early biomarker for assessing bleeding severity. Obj...
Simulation of atherosclerosis-related thrombus evolution in representative vascular geometries using Immersed Boundary 2D [0.03%]
基于Immersion Boundary Method的动脉粥样斑块破裂及血栓形成的二维几何结构代表性模拟研究
Yixuan Wang,Shutao Wei,Jiankun Wang et al.
Yixuan Wang et al.
Thrombus formation in atherosclerosis-related vascular regions is influenced by complex and spatially varying hemodynamic conditions. While low shear stress and flow recirculation have been widely associated with increased thrombotic risk, ...
Temporal trends and risk factors of extracranial major bleeding in patients with acute pulmonary embolism [0.03%]
急性肺栓塞患者重大颅外出血的时空变化及危险因素分析
Konstantinos C Christodoulou,Lukas Hobohm,Katharina Mohr et al.
Konstantinos C Christodoulou et al.
Background: Major bleeding is a crucial event in patients with pulmonary embolism (PE) accompanied by high morbidity and mortality. While the major bleeding research focus primarily on intracranial bleeding, research rega...
Integrative transcriptomics elucidates core regulatory network governing human megakaryopoiesis: Insights from CD34+-derived megakaryocyte maturation [0.03%]
整合转录组学阐明了调控人类巨核细胞生成的核心调节网络：来自CD34+衍生的巨核细胞成熟的见解
Ziyan Zhang,Yue Wang,Peng Liu
Ziyan Zhang
Megakaryopoiesis is an elaborate biological process that primarily occurs in the bone marrow. To gain deeper insights into molecular mechanisms driving normal megakaryopoiesis, we utilized an in vitro human megakaryocytic culture system bas...
Thrombophilia assessment with thrombin generation assay at diagnosis and during induction therapy in children with acute lymphoblastic leukemia [0.03%]
儿童急性淋巴细胞白血病诊断时和诱导治疗期间的血栓生成试验评估血栓形成倾向性
Gorkem Oguz,Yilmaz Ay,Sebnem Onen Goktepe et al.
Gorkem Oguz et al.
Thrombosis is a significant complication of childhood acute lymphoblastic leukemia (ALL) associated with both the disease itself and its treatment. This study aimed to predict the thrombotic process with TGA performed at diagnosis and durin...
The safety of direct oral anticoagulants use during lactation: A systematic review [0.03%]
直接口服抗凝血药哺乳期使用的安全性：系统性综述
Flavia Nunes Benicio,Luís Felipe Leite,Luiz Felipe Costa de Almeida et al.
Flavia Nunes Benicio et al.
Introduction: Direct Oral Anticoagulants (DOACs) are generally not recommended during breastfeeding due to limited data on milk transfer and potential effects on the infant. The main advantages of DOACs over the other ant...
Sex differences in gastrointestinal bleeding among patients with cardiovascular diseases: A secondary analysis of the INTERBLEED study [0.03%]
心血管病患者中胃肠出血的性别差异——INTERBLEED研究的二次分析
Yaoyao Cai,Jacqueline Bosch,Jun Zhu et al.
Yaoyao Cai et al.
Objective: Gastrointestinal (GI) bleeding is a serious complication among patients with cardiovascular disease (CVD). This study aimed to evaluate sex differences in the odds of GI bleeding. ...
Techniques for measuring NETosis: A critical literature review and outlook for standardization [0.03%]
NETosis测量技术：批判性文献回顾及标准化展望
Constant Gillot,Hachem Bouarroudj,Jonathan Decarpentrie et al.
Constant Gillot et al.
Background: Neutrophil extracellular traps (NETs) are key components of innate immunity, but NETosis research is limited by the absence of standardized biomarkers and analytical protocols. The rapid expansion of NET-relat...
Human iPSC-derived platelets generated in alginate scaffolds exhibit functional haemostasis in vitro and in vivo [0.03%]
藻酸盐支架中生成的人iPSC衍生血小板具有体内外止血功能
Marina Tarunina,Richard Amison,Tatyana Ponomaryov et al.
Marina Tarunina et al.
The manufacture of platelets from induced pluripotent stem cells (iPSCs) in a cost-effective, controlled and reproducible manner is a critical challenge for transfusion and regenerative medicine applications. Here we employ a high throughpu...