Has systemic thrombolysis run its course? A systematic review and network meta-analysis of patients with intermediate- and high-risk pulmonary embolism [0.03%]
系统性溶栓疗法是否已经走到尽头？一项关于中高危肺血栓栓塞患者的系统评价和网络meta分析
Gal Aviel,Bruria Raccah-Hirsh,Rafat Abu-Ghannam et al.
Gal Aviel et al.
Background: Traditionally, first-line reperfusion strategy recommendation for patients with hemodynamically significant pulmonary embolism (PE) is systemic thrombolysis (ST). ST is associated with serious adverse events. ...
Reduced ADP-induced platelet aggregation may predict poor clinical outcomes in patients with COVID-19 [0.03%]
ADP诱导的血小板聚集降低可能预示着COVID-19患者的不良临床结局
Hiroyuki Koami,Yuichiro Sakamoto,Yutaro Furukawa et al.
Hiroyuki Koami et al.
Background: COVID-19-associated coagulopathy remained a major contributor to mortality and morbidity even after mutation to the Omicron strain. Pathologic platelet hyperactivation caused by COVID-19 infection is generally...
Evaluating the safety outcomes of whole blood versus component transfusion in trauma: A meta-analysis of 59,213 patients [0.03%]
评估全血与成分输血在创伤患者中的安全性结局：一项包含59213例患者的meta分析研究
Muhammad Taha Khan,Fatima Ali Raza,Rafiya Altaf et al.
Muhammad Taha Khan et al.
Background: Blood transfusion can play a critical role in saving lives by replenishing lost blood volume and helping to stabilize patients. This meta-analysis aims to compare the clinical effectiveness of whole blood (WB)...
Thrombectomy in high-risk pulmonary embolism - device versus thrombolysis: rationale and design of the TORPEDO-NL investigator-initiated, academically-sponsored, multicenter, open-label randomized controlled trial [0.03%]
高危肺栓塞患者导管取栓对比溶栓治疗：TORPEDO-NL研究（一项荷兰的学者发起并学术赞助的多中心开放标签随机对照临床试验）的设计和方法学
W J E Stenger,C A den Uil,W J R Rietdijk et al.
W J E Stenger et al.
Background: Catheter-directed thrombectomy (CDT) is a promising alternative to full dose thrombolysis in patients with acute high-risk pulmonary embolism (PE), expected to have a more direct effect on pulmonary artery clo...
Prolonged duration of pharmacological thromboprophylaxis following oncologic surgery: A systematic review and meta-analysis of RCTs [0.03%]
肿瘤手术后延长药物血栓预防时间：随机对照试验的系统评价和meta分析
Zhongwang Wang,Zhengyu Yu,Ting Niu
Zhongwang Wang
Background: Venous thromboembolism (VTE) is the leading cause of 30-day postoperative mortality, with current guidelines recommending extended-duration thromboprophylaxis despite limited evidence on its impact on clinical...
Extracellular histones promote retraction and impair lysability of platelet-rich clots [0.03%]
细胞外组蛋白促进血小板凝块的回缩并抑制其溶解能力
Concetta T Ammollo,Nicola Semeraro,Mario Colucci et al.
Concetta T Ammollo et al.
Comparative analysis of perioperative management of antiplatelet agent guidelines across US institutions [0.03%]
美国各大医疗机构围手术期抗血小板药物管理指南的比较分析
Ming Y Lim,Jacob C Cogan,Caroline Cromwell et al.
Ming Y Lim et al.
Introduction: Cardiovascular disease (CVD) is the leading cause of mortality worldwide, prompting increasing use of antiplatelet agents for primary and secondary prevention. Despite guidelines from multiple professional s...
Linezolid impair proplatelet formation by reducing mitochondrial energy metabolism in MEG-01 cells [0.03%]
利奈唑胺通过降低MEG-01细胞线粒体能量代谢而抑制血小板生成
Ya Yang,Ning Wang,Lirong Xiong et al.
Ya Yang et al.
Background: Thrombocytopenia is a common adverse side effects of Linezolid (LZD) but the underlying mechanism remains unclear. This study aimed to analyze the mechanism of LZD induced thrombocytopenia for LZD induced thro...
An international survey of clinician recommendations for physical activity after venous thromboembolism [0.03%]
一项关于深静脉血栓形成后体能活动的国际调查研究
Antonia Chan,Pavlina Chrysafi,Dana Angelini et al.
Antonia Chan et al.
Sepsis-related coagulation-inflammation score: Development and validation for predicting 28-day mortality in patients with sepsis [0.03%]
脓毒症相关凝血炎症评分在脓毒症患者中28天死亡率预测中的建立和验证
Ji Jiang,Haicong Huang,Huiya Li et al.
Ji Jiang et al.
Background: Sepsis remains a leading cause of mortality in intensive care units worldwide, characterized by dysregulated host response to infection involving complex interactions between coagulation and inflammatory pathw...