Effectiveness and safety of direct oral anticoagulants in patients with thrombotic antiphospholipid syndrome and venous thrombosis: A retrospective cohort study [0.03%]
直接口服抗凝血剂治疗抗磷脂综合征合并静脉血栓患者的疗效及安全性：回顾性队列研究
Anne Lind Malte,Anders Mønsted Abilgaard,Johanne Andersen Hojbjerg et al.
Anne Lind Malte et al.
Background: Vitamin K antagonists (VKA) are the recommended treatment for thrombotic antiphospholipid syndrome (TAPS), but it remains uncertain whether direct oral anticoagulants (DOAC) could serve as an alternative to VK...
Thrombus formation, endogenous fibrinolysis and atrial fibrillation states in patients with ischaemic stroke: An assessment using global thrombosis test profiles [0.03%]
缺血性卒中患者血栓形成、内源性纤维蛋白溶解和心房颤动状态的全球血栓检测谱分析
Yang Chen,Ying Gue,Sandra Elsheikh et al.
Yang Chen et al.
Background: Atrial fibrillation (AF) is often first detected during or after ischaemic stroke (IS), yet many cases remain undetected. We evaluated whether thrombotic and fibrinolytic profiles vary with AF status in IS and...
Pre-analytical storage and reagent-dependent sensitivity as sources of variability in prothrombin time and activated partial thromboplastin time measurements [0.03%]
凝血酶原时间和活化部分凝血活酶时间检测中变异来源的探究——样本储存和试剂依赖性敏感度的影响
A D van Dam,M M Bioch,E H Jeninga et al.
A D van Dam et al.
Background: Prothrombin time (PT) and activated partial thromboplastin time (aPTT) are widely used coagulation assays whose results can vary due to pre-analytical and analytical factors. Understanding these sources of var...
Apoptotic versus procoagulant platelets: similar "necrotic" phenotype and procoagulant activity in vitro, but distinct adhesive protein composition [0.03%]
凋亡血小板与促凝血血小板的区别：“坏死”表型和体外促凝活性类似，但粘附蛋白组成不同
N A Podoplelova,S I Obydennyi,A A Ignatova et al.
N A Podoplelova et al.
Platelets can undergo at least two distinct types of regulated cell death, apoptosis and mPTP-driven necrosis. Apoptosis is believed to be responsible for platelet clearance, while strong platelet activation by physiological agonists leads ...
Heatstroke-induced coagulopathy: A scoping review of therapeutic strategies and outcome reporting [0.03%]
关于中暑所致凝血障碍的治疗策略及结局报告的系统综述性文章
Takuto Yasuda,Kasumi Satoh,Kei Imai et al.
Takuto Yasuda et al.
Heatstroke-induced coagulopathy (HSIC) is a life-threatening complication of heatstroke that often progresses to disseminated intravascular coagulation. Despite its prognostic significance, standardized treatment strategies have not yet bee...
Mapping thrombus habitat: Non-contrast MRI radiomics and pixel-tile histomics approach to track venous thrombosis evolution in mice [0.03%]
基于非对比度MRI影像组学和像素-瓷砖病理组学的血栓演化追踪方法
Sicheng Yao,Xinran Wu,Yingxin Liu et al.
Sicheng Yao et al.
Background: Determining the age and composition of deep vein thrombosis (DVT) is essential for optimizing thrombus removal strategies, yet clinical decision-making remains restrained by the subjectivity of symptom-based a...
A study protocol for a randomised controlled trial evaluating the safety and efficiency of the YEARS algorithm versus computed tomography pulmonary angiography only for suspected acute pulmonary embolism in patients with cancer: the Hydra Study [0.03%]
YEARS方案与仅行肺计算机断层扫描血管造影检查在癌症患者的疑似急性肺栓塞患者中安全性和有效性的比较：Hydra研究实施方案
E S L Martens,B Akerboom,C Baumgartner et al.
E S L Martens et al.
Background: Pulmonary embolism (PE) is frequently suspected in patients with cancer due to non-specific symptoms suggestive of PE and their inherent risk of venous thromboembolism (VTE). Commonly used clinical decision ru...
Associating the phenotypic expression of platelets with disease type through image-based single-cell profiling [0.03%]
基于图像的单细胞分析在血小板表型与疾病的关联研究中的应用
Huidong Wang,Masako Nishikawa,Yuqi Zhou et al.
Huidong Wang et al.
Background: Platelets are central to hemostasis and thrombosis and contribute to diverse diseases, including cardiovascular disorders, infections, and cancer. Although platelet activation and dysfunction in disease have b...
The mechanisms of contractile dysfunction following chronic limited platelet activation in (pro)thrombotic conditions [0.03%]
慢性血小板有限活化在（前）血栓形成条件下的收缩功能障碍机制
Alina I Khabirova,Rafael R Khismatullin,Shakhnoza M Saliakhutdinova et al.
Alina I Khabirova et al.
Background: Patients with (pro)thrombotic conditions often exhibit a combination of platelet activation and dysfunction, including impaired contractility, which may contribute to thrombosis progression. ...
Molecular basis of the E69Q and R383W heterozygous F2 variants identified in the proband associated with severe hemostatic defects [0.03%]
与严重止血缺陷相关的受检者来源的F2基因杂合突变E69Q和R383W的分子基础研究
Liya Lin,Yang Li,Changming Chen et al.
Liya Lin et al.
Background: Functional studies of F2 variants causing congenital prothrombin deficiency are few. Objectives: To investigate the molecul...