Hepatic toxicity induced by exposure to glyphosate/aminomethylphosphonic acid and oxytetracycline alone or in combination in zebrafish: A novel mechanism of the gut-liver axis [0.03%]
草甘膦/氨基甲基磷酸与 oxytetracycline 单独或联合作用于斑马鱼肝毒性的研究：肠道-肝脏轴作用的新机制
Junyue Zheng,Chen Wang,Miaomiao Teng et al.
Junyue Zheng et al.
Glyphosate (Gly) is the most commonly used herbicide in the world. Glyphosate and its main degradation product, aminomethylphosphonic acid (AMPA), are often detected in aquatic environments and may pose a threat to the health of aquatic org...
Mechanistic insights into the effects of Fluoxetine in Mytilus galloprovincialis using in vivo and in vitro approaches [0.03%]
采用体内和体外方法研究氟西汀对地中海贻贝(Mytilus galloprovincialis)的影响机制
Teresa Balbi,Paola Valbonesi,Marilin Profita et al.
Teresa Balbi et al.
Antidepressants such as selective serotonin reuptake inhibitors (SSRIs) are pseudo-persistent contaminants in aquatic ecosystems. While their effects and molecular targets are relatively well understood in vertebrates, less information is a...
Tissue uptake, distribution, elimination and neurotoxicity of decabromodiphenyl ethane (DBDPE) in adult zebrafish (Danio Rerio) [0.03%]
十溴二苯乙烷在成年斑马鱼体内的组织摄取、分布、消除及神经毒性作用研究
Xiaochen Wang,Kaiyu Fu,Jianghuan Hua et al.
Xiaochen Wang et al.
Decabromodiphenyl ethane (DBDPE), a novel brominated flame retardant, has been widely detected in various environmental media and exhibits significant bioaccumulation potential. This study first analyzed the distribution characteristics of ...
Crosstalk with the cholinergic pathway may be responsible for chlorpyrifos-induced reproductive toxicity in fish [0.03%]
与胆碱能通路的串扰可能是毒死蜱引起鱼类生殖毒性的原因
Aoxue Wang,Yujia Yan,Yuyao Jiang et al.
Aoxue Wang et al.
Chlorpyrifos (CPF), a commonly applied organophosphate insecticide, is known to disrupt the endocrine systems of aquatic species. However, further research is required to elucidate the molecular mechanisms involved in the reproductive toxic...
Ping-Ping Zhang,Chong-Rui Yao,Wen-Jun Shi et al.
Ping-Ping Zhang et al.
Aquatic ecosystems are increasingly threatened by diverse environmental pollutants, such as pharmaceuticals, personal care products, and persistent organic contaminants. While traditional in vivo fish models and two-dimensional (2D) cell cu...
Zebrafish Abcg2a mutant line as an in vivo model for evaluation of the interaction of Abcg2a with drugs and contaminants [0.03%]
斑马鱼Abcg2a突变体作为评估药物和污染物与Abcg2a相互作用的体内模型
Jovica Lončar,Roko Žaja,Ivan Mihaljević et al.
Jovica Lončar et al.
As a member of the ABC transporter superfamily, ABCG2 is a half transporter that mediates the translocation of various xenobiotic substrates across cell membranes, playing an essential role in cellular detoxification. With the aim of develo...
A metabolomics study unravels the hepatotoxic mechanism of diuron in zebrafish: Disruption of glutathione synthesis and mitochondrial energy metabolism [0.03%]
一种除草剂尿隆诱发斑马鱼肝毒性的代谢组学研究：谷胱甘肽合成及线粒体能量代谢紊乱导致肝毒性
Jingjing Shi,Tianlie Luo,Zhuang Wang et al.
Jingjing Shi et al.
The liver plays a central role in xenobiotic metabolism and is consequently highly vulnerable to chemical-induced injury. Nevertheless, the mechanisms underlying diuron-induced hepatotoxicity remain poorly understood. Zebrafish (Danio rerio...
Developmental exposure to Bisphenol S causes neurobehavioural deficits in larval zebrafish (Danio rerio) [0.03%]
-developmentalsbs-暴露于双酚s导致斑马鱼（丹尼俄勒 Ryerii）幼虫出现神经行为缺陷
A K M Munzurul Hasan,Mahesh Rachamalla,Md Helal Uddin et al.
A K M Munzurul Hasan et al.
Bisphenol S (BPS) is a widely used synthetic compound and is known as an endocrine-disrupting chemical (EDC). The ability of BPS to bind predominantly to estrogen receptors raises significant concern, as it can interfere with different neur...
Chronic paternal or maternal exposure to florfenicol causes reproductive and developmental toxicity in marine medaka (Oryzias melastigma) [0.03%]
氟苯尼考的慢性父系或母系暴露会导致拟咽齿鱼(Oryzias melastigma)生殖和发育毒性
Xingying Guo,Tan-Duc Nguyen,Qingshi Chen et al.
Xingying Guo et al.
New pollutants impair the reproduction and development of offspring in marine fish after parental exposure. While florfenicol has been frequently detected in the environment and organisms, limited information is available on its effects on ...
Molecular interactions and biomarker responses to pharmaceutical contaminants in aquatic species [0.03%]
活性化合物污染物的分子效应及水生生物标志响应研究进展与挑战
Dibakar Roy,Mokhtar Rejili,Wasim Ghafoor et al.
Dibakar Roy et al.
Pharmaceutical residues are increasingly detected in freshwater systems, yet mechanistic links between sub-lethal exposure and organ-level injury in fish remain limited. This study assessed 21-day effects of carbamazepine (CBZ), diclofenac ...