Acute disturbance, but chronic re-equilibration of the oyster metabolome to 17β-estradiol and nonylphenol exposure [0.03%]
急性干扰，但长期适应于雌二醇和辛基苯酚暴露的牡蛎代谢组
Sazal Kumar,Wayne A O&#x;Connor,Allison C Luengen et al.
Sazal Kumar et al.
In estuaries, aquatic organisms are often exposed to estrogenic endocrine disrupting chemicals (EEDCs), including 17β-estradiol (E2) and nonylphenol (NP), which affect physiology and metabolism. This study evaluated metabolic profiles of S...
Elucidating toxicity mechanisms of hexabromocyclododecane in marine microalga Chlorella salina: An integrated biomacromolecular and transcriptomic analysis [0.03%]
基于大型生物分子和转录组学的整合分析阐明六溴环十二烷对海洋微藻小盐藻毒性的机制研究
Fei Tian,Xuefeng Wang,Lihua Lai et al.
Fei Tian et al.
Hexabromocyclododecane (HBCD), a persistent brominated flame retardant, poses substantial ecological risks attributable to its bioaccumulation potential and toxicity. This study explored the toxic impacts of HBCD on the marine microalgae Ch...
Bioaccumulation and toxicity of hexafluoropropylene oxide homologs in Manila clams (Ruditapes philippinarum) compared with PFOA: Correlations with molecular backbone length [0.03%]
六氟环氧丙烷同系物与PFOS和PFOA相比，对菲律宾蛤仔生物累积及毒性的影响：与分子主链长度的关系
Hanlin Qin,Qianqian Geng,Yujie Bi et al.
Hanlin Qin et al.
As emerging per-and polyfluoroalkyl substances (PFAS), hexafluoropropylene oxide (HFPO) homologs are substitutes for perfluorooctanoic acid (PFOA), but exhibit widespread environmental distribution, high bioaccumulation potential, and multi...
Unveiling the hidden impacts: A comprehensive review of microplastic effects on marine bivalves [0.03%]
拨开隐形的影响：关于微塑料对海洋双壳纲软体动物影响的全面回顾
Zhaowen Chen,Sijie Fan,Wenbo Guo et al.
Zhaowen Chen et al.
Microplastics (MPs) pollution has become a global environmental issue, posing significant potential risks to marine ecosystems, especially bivalve mollusks. Studies have shown that bivalves are at increased risk of ingesting and accumulatin...
Toxicity of tetrachlorobisphenol A interfering with craniofacial cartilage development by inhibiting RXR activity in zebrafish [0.03%]
四氯双酚A通过抑制视黄酸受体活性干扰斑马鱼颅面软骨发育的毒性作用研究
Xiaomei Chen,Hanyi Zhu,Yinliang Zhong et al.
Xiaomei Chen et al.
Tetrachlorobisphenol A (TCBPA), a prevalent halogenated flame retardant detected in human serum and breast milk, poses significant exposure risks during developmental windows. While recognized for reproductive toxicity, its impact on cranio...
Synergistic cytotoxicity of gymnodimine-A and okadaic acid in Caco-2 cells through coordinated disruption of calcium homeostasis and oxidative stress [0.03%]
通过协同扰乱钙稳态和氧化应激导致gymnodimine-a和okadaic酸在Caco-2细胞中的协同毒性作用
Guixiang Wang,Jiangbing Qiu,Ruolin Wu et al.
Guixiang Wang et al.
The lipophilic phycotoxins gymnodimine-A (GYM-A) and okadaic acid (OA) are frequently detected in shellfish globally, posing a potential threat to human health through combined dietary exposure. Thus, this study aimed to evaluate the combin...
Marine and freshwater mussels as biomonitors for microplastic concentrations: A comparative laboratory study [0.03%]
利用双壳纲无铰类软体动物监测微塑料浓度：一项对比实验研究
Adèle Wolinski,Miléna Ferret,Basile Bergeron et al.
Adèle Wolinski et al.
Microplastics are pervasive in both freshwater and marine waters, posing potential hazards to a wide range of species. Evaluating environmental microplastic pollution is crucial for ecological risk assessment. However, current monitoring me...
Hydra as a dual-utility model for cytotoxicity and genotoxicity: Bridging environmental toxicology and therapeutic applications [0.03%]
水螅作为细胞毒性和遗传毒性双用途模型：环境毒理学和治疗应用之间的桥梁
Jagadisha Tavarekere Venkataravanappa,Saraswathi Saraswathi,Nayana Mitta Lakshminarayana Gupta et al.
Jagadisha Tavarekere Venkataravanappa et al.
Hydra, a simple freshwater cnidarian, is gaining recognition as a valuable alternative model for toxicological research due to its ease of cultivation, exceptional regenerative capacity, and well-characterized cell lineages. While the exist...
Combined impacts of a lipid lowering drug, gemfibrozil, and temperature on bioenergetics and digestive gland function of a marine bivalve Mytilus edulis [0.03%]
一种降脂药物和温度对海洋双壳类Mytilus edulis生物能学和消化腺功能的综合影响
Inna M Sokolova,Halina Falfushynska,Eugene P Sokolov et al.
Inna M Sokolova et al.
Pharmaceutical fibrates are increasingly detected in coastal waters, yet their organism-level effects under realistic thermal regimes remain poorly resolved. We tested how environmentally relevant gemfibrozil (GFB) exposure interacts with t...
Nomilin mitigates OBS-induced developmental cardiotoxicity via the Nrf2 pathway [0.03%]
Nomilin通过Nrf2途径缓解OBS诱导的发育性心脏毒性
Xing Liu,Yi Fan,Ruobing Chen et al.
Xing Liu et al.
Sodium p-perfluorous nonenoxybenzenesulfonate (OBS) is widely used in industry as a replacement for perfluorooctanesulfonic acid (PFOS) and has attracted considerable attention due to its environmental persistence and toxicity. However, lim...