The m6A demethylase FTO suppresses perivascular adipose tissue browning and exacerbates vascular injury via m6A-mediated destabilization of Irx3 mRNA and the IRX3/UCP1 axis [0.03%]
通过mRNA N6-甲基腺苷（m6A）介导的Irx3信使核糖核酸（mRNA）不稳定性及IRX3/UCP1轴抑制血管周围脂肪组织褐变并加重血管损伤：FTO的作用
Xiaoyong Hu,Hongjian Li,Zhaoying Yang et al.
Xiaoyong Hu et al.
Background and aims: Vascular injury triggers perivascular adipose tissue (PVAT) browning, an adaptive response critical for vascular protection, yet its regulatory mechanisms remain unclear. This study aimed to identify ...
PCSK9 expression in human atherosclerotic lesions and vascular smooth muscle cells [0.03%]
人类动脉粥样硬化斑块和血管平滑肌细胞中PCSK9的表达
Yara Azar,Yara Abou Khalil,Marie-Nathalie Lebel et al.
Yara Azar et al.
Aims: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is the third gene involved in autosomal dominant hypercholesterolemia, an atherosclerosis major cause. Its role in regulating plasma cholesterol through hepatocy...
Culprit in custody but disease remains at large: OCT substrate and the residual SYNTAX score [0.03%]
罪犯虽获拘禁然而疾病仍然肆虐：光学相干断层扫描基底病变和术后残留SYNTAX评分
Jonathan A Aun,Carlos R Martinez Licha,Edward A Hulten
Jonathan A Aun
Bidirectional association between breast cancer and cardiovascular disease: Longitudinal analysis of UK Biobank data [0.03%]
乳腺癌和心血管疾病之间的双向关联——英国生物银行数据的纵向分析
Zijia Liu,Fengjun Du,Chunhua Zhao et al.
Zijia Liu et al.
Background and aims: Breast cancer (BC) and cardiovascular disease (CVD) are leading causes of death in women. However, their bidirectional relationship and key risk factors remain unclear. ...
Hepatic GSTM3 deficiency Accelerates Atherosclerosis through redox-driven mitochondrial dysfunction and necroinflammation in Apoe-/- mice [0.03%]
小鼠肝GSTM3缺乏通过氧化还原驱动的线粒体功能障碍和坏死性炎症加速动脉粥样硬化形成
Trina Roy,Aleepta Guha Ray,Subhamoy Pratihar et al.
Trina Roy et al.
Background and aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) is closely associated with accelerated atherosclerosis and cardiovascular complications, yet the hepatic redox-dependent mechanisms lin...
Association between remnant cholesterol and peripheral artery disease from multiple perspectives [0.03%]
从多角度分析残余胆固醇与外周动脉疾病的关系
Wenzhuo Meng,Cong Wang,Zeqin Xu et al.
Wenzhuo Meng et al.
Background and aims: Remnant cholesterol (RC) has emerged as an atherogenic lipid fraction that may be associated with residual cardiovascular risk beyond low density lipoprotein cholesterol (LDL-C). However, its role in ...
Organoid models reveal mechanistic connections and sirolimus efficacy in liver-vascular steatosis and foam cell formation [0.03%]
类器官模型揭示了肝脏血管脂肪变性和平滑肌泡沫细胞形成的机制联系及西罗莫司的治疗效果
Vishnu Goutham Kota,Jordan Low Jun Yi,Zhiyi Zhang et al.
Vishnu Goutham Kota et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) and its progressive form, metabolic dysfunction-associated steatohepatitis (MASH), are the leading chronic liver diseases globally and are closely linked to systemic metabolic...
Reply - PPG meta-analysis: methodological and clinical considerations [0.03%]
连续性肾脏替代治疗的PPGMeta分析：方法学和临床相关问题考虑因素回复
Adrian Bednarek,Mariusz Tomaniak
Adrian Bednarek