Juying Han,Emmanuel Opoku,Gregory Brubaker et al.
Juying Han et al.
Background and aims: An AKRxDBA/2 mouse strain intercross identified an atherosclerosis modifier gene within a small region on chromosome 2, containing only three protein coding genes, including Z-DNA binding protein 1 (Z...
Longitudinal changes and borderline reclassification of Lipoprotein(a) compared with conventional lipids in over 230,000 adults [0.03%]
基于脂蛋白(a)与传统血脂纵向变化及边缘型再分类的队列研究(超过23万名成人数据)
Da-Eun Sung,Mi-Yeon Lee,Min-Jung Kwon et al.
Da-Eun Sung et al.
Background and aims: Lipoprotein(a) [Lp(a)] is a genetically determined cardiovascular risk factor. Although generally considered stable, data on intra-individual reclassification of Lp(a) categories over time compared wi...
Coronary lipid burden indices predict non-culprit major adverse cardiac events independently of novel LDL estimates: Insights from the LRP study [0.03%]
冠脉脂质负荷指标能独立于新型LDL估计值预测非罪犯病变主要心血管不良事件——来自LRP研究的新见解
Kayode O Kuku,Hector M Garcia-Garcia,Gary S Mintz et al.
Kayode O Kuku et al.
Background and aims: Coronary Lipid Burden measured by NIRS-IVUS (maxLCBI4mm > 400) predicts non-culprit major adverse cardiac events (MACE) but has shown weak correlation with traditional low-density lipoprotein (LDL) me...
Clinical impact of systemic inflammation across different high-sensitivity C-reactive protein cutoffs in patients undergoing percutaneous coronary intervention [0.03%]
不同高敏C反应蛋白截点下经皮冠状动脉介入治疗患者全身炎症的临床影响
Angelo Oliva,Mark Shneyderman,Mauro Gitto et al.
Angelo Oliva et al.
Background and aims: Systemic inflammation enhances coronary atherosclerosis progression and is assessed by high-sensitivity C-reactive protein (hsCRP). However, heterogeneity exists in defining the optimal hsCRP threshol...
Association between cardiovascular-kidney-metabolic syndrome, inflammatory biomarkers, and cardiovascular outcomes: Insights from the MESA study [0.03%]
心血管-肾脏-代谢综合征、炎症标志物与心血管结局的相关性——来自MESA研究的启示
Muhammad Imtiaz Ahmad,Parag Chevli,Saeid Mirzai et al.
Muhammad Imtiaz Ahmad et al.
Background: This study investigated the association between cardiovascular-kidney-metabolic (CKM) syndrome stages 0-3 and atherosclerotic cardiovascular disease (ASCVD) and heart failure (HF), as well as whether this asso...
Single-cell RNA-sequencing reveals adventitial fibroblast alterations during mouse atherosclerosis [0.03%]
单细胞RNA测序揭示动脉粥样硬化小鼠外膜成纤维细胞的改变
Lauren E Fries,Allen Chung,Hyun-Kyung Chang et al.
Lauren E Fries et al.
Background: Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of mortality in the western world despite the success of lipid lowering therapies, highlighting the need for novel lipid-independent the...
Associations of high-density lipoprotein cholesterol levels with the presence and severity of coronary atherosclerosis [0.03%]
高密度脂蛋白胆固醇水平与冠状动脉粥样硬化病变的相关性研究
Jari A Laukkanen,Timo Pohjonen,Sudhir Kurl et al.
Jari A Laukkanen et al.
Background and aims: Emerging evidence suggest a controversial relationship between high-density lipoprotein cholesterol (HDL-C) and adverse cardiovascular outcomes. We aimed to explore the associations of serum HDL-C lev...
Patient perspectives on statin intolerance, attribution of the nocebo effect and use of N=1-interventions: a qualitative focus group study [0.03%]
他者视角下的降脂药不耐受、“否定效应”及其个体N=1试验干预：定性焦点小组研究
Ruben J M Mijnster,Marte F van der Bijl,Amber Niesthoven et al.
Ruben J M Mijnster et al.
Background and aims: Statin-associated symptoms often occur under therapy, though N=1-interventions suggest most symptoms may not be attributable to the therapy itself and might be related to the nocebo effect. This study...
Residual cardiovascular risk in CKD: Reevaluating remnant cholesterol and inflammation [0.03%]
慢性肾脏病患者的残余心血管风险：重新评估残余胆固醇和炎症的影响
Haiting Huang,Guirong Dong
Haiting Huang