Laminar shear stress inhibits endothelial-mesenchymal transition and mitigates atherosclerosis through SRXN1 [0.03%]
层流剪切应力通过SRXN1抑制内皮-间充质转化并减轻动脉粥样硬化
Xingyu Jiang,Qingyu Meng,Luya Pu et al.
Xingyu Jiang et al.
Background and aims: Atherosclerosis (AS), a critical inflammatory condition of the arteries that leads to cardiovascular diseases, has a complex pathophysiological mechanism involving multifactorial interactions. Endothe...
Heribert Schunkert
Heribert Schunkert
Genetic disposition accounts for about half of the risk to develop coronary artery disease (CAD). Yet, Mendel's Laws fail to explain its high prevalence. The conceptual dilemma was resolved by the common-disease-common-variant hypothesis, w...
Robert S Rosenson,Deepthi Nishi Velamuri,Paul Muntner et al.
Robert S Rosenson et al.
Background and aims: Remnant cholesterol (RC), the cholesterol transported in triglyceride-rich lipoprotein (TRL) remnants, has emerged as a major contributor to residual atherosclerotic cardiovascular disease (ASCVD) ris...
Lipid clinics worldwide: harmonization and guidance on how to optimally organize and fund. European Atherosclerosis Society consensus statement across 55 countries and more than 500 lipid clinics [0.03%]
全球范围内的脂质诊所：如何优化组织和资助的协调与指导。欧洲动脉粥样硬化学会55个国家以上和500多家脂质诊所共识声明
Christian Bork,Børge G Nordestgaard,Berit Storgaard Hedegaard et al.
Christian Bork et al.
Because one in three of all individuals die from atherosclerotic cardiovascular disease (ASCVD), prevention of ASCVD is key to public health worldwide. Lipid clinics provide specialized diagnostic assessment, lifestyle management, and evide...
NOD1 ligand FK565 promotes atherogenesis and accumulation of NOD1+ smooth muscle cells in atherosclerotic lesions [0.03%]
NOD1配体FK565促进动脉粥样硬化和NOD1+平滑肌细胞在动脉粥样硬化斑块中聚集
Xiao-Ying Zhang,Xin-Tong Jiang,Anton Gisterå et al.
Xiao-Ying Zhang et al.
Background and aims: Nucleotide-binding oligomerization domain-containing protein (NOD)1 is an intracellular pattern recognition receptor that initiates immune responses upon ligation of molecules such as bacterial peptid...
Ida Juul Rasmussen,Jiao Luo,Katrine Laura Rasmussen et al.
Ida Juul Rasmussen et al.
Approximately 50 million people are living with dementia worldwide, a number projected to reach more than 150 million by 2050. Dementia has emerged as one of the most pressing public health challenges globally, and it is increasingly recogn...
Bridging discovery and clinical science: A framework for advancing atherosclerosis research using innovative models [0.03%]
推动动脉粥样硬化研究的创新模型及其临床应用框架
Kaloyan Takov,Marie A C Depuydt,Christophe A T Stevens et al.
Kaloyan Takov et al.
Atherosclerotic cardiovascular disease (ASCVD) is a leading cause of death, with substantial residual risk persisting despite current lipid-lowering, antithrombotic, antihypertensive, weight-management, and anti-inflammatory therapies. This...
The global burden of calcified aortic valve stenosis: epidemiology, risk factors, disparities, and future perspectives - a narrative review [0.03%]
全球钙化性主动脉瓣狭窄的疾病负担：流行病学、危险因素、不平等状况和未来展望——叙述性综述
Kimberley Iris Hemelrijk,Ronak Delewi,Roxana Mehran et al.
Kimberley Iris Hemelrijk et al.
Calcific aortic valve stenosis (CAVS) is the most common valvular heart disease requiring intervention. Progressive fibrocalcific thickening of the valve leaflets results in left ventricular outflow tract obstruction. Once symptoms emerge, ...
Identification of near-infrared spectroscopy-defined lipid content within or adjacent to calcified coronary plaques using optical coherence tomography [0.03%]
利用光学相干断层扫描识别冠状动脉斑块内或其附近的脂质含量（近红外光谱法定义）
Tatsuhiro Nagamine,Eisuke Usui,Yoshihisa Kanaji et al.
Tatsuhiro Nagamine et al.
Background and aims: Calcified coronary plaques frequently harbor lipid-rich components, yet identifying residual lipid burden within calcification remains challenging. This study aimed to evaluate the ability of optical ...