Precision and network medicine in cardiovascular prevention and disease [0.03%]
精准和网络医学在心血管病预防及治疗中的应用
Arvind K Pandey,Joseph Loscalzo
Arvind K Pandey
Cardiovascular diseases are characterized by mechanistic heterogeneity, varied genetic and environmental risk factors, and diverse clinical manifestations. Precision medicine has emerged as a paradigm to identify patient subgroups more clea...
Exercise as medicine: Improving cardiovascular health through physical activity [0.03%]
运动与健康：通过身体活动改善心血管健康
Shriyam Bhardwaz,Heribert Schunkert,Hendrik B Sager
Shriyam Bhardwaz
Cardiovascular diseases remain the leading cause of global mortality, and growing evidence shows that regular exercise is one of the most effective non-pharmacological strategies to prevent and modify their progression. Exercise exerts its ...
Hematopoietic somatic mutations in atherosclerotic cardiovascular disease [0.03%]
造血系统体细胞性突变与动脉粥样硬化性心血管疾病的关系
Beatriz L Ramos-Neble,José J Fuster
Beatriz L Ramos-Neble
Age-related somatic mosaicism in the hematopoietic system is increasingly recognized as a risk factor for atherosclerotic cardiovascular disease. The most prominent example is clonal hematopoiesis of indeterminate potential (CHIP), defined ...
The secretory PCSK family in cardiovascular disease and beyond [0.03%]
PCSK家族的分泌作用在心血管疾病及其相关领域中的作用机制研究
Nabil G Seidah
Nabil G Seidah
It took >20 years to discover the family of proteases implicated in the activation and/or regulation of the activity of secretory proteins, including polypeptide hormones, growth factors and receptors. From 1990 to 2003 the 9 members of the...
Long-term prognostic impact of optical coherence tomography detected plaque rupture in nonculprit coronary segments [0.03%]
光学相干层析成像检测的非罪犯冠状动脉节段斑块破裂长期预后的影像学影响因素研究
Flavio Giuseppe Biccirè,Eloisa Arbustini,Yukio Ozaki et al.
Flavio Giuseppe Biccirè et al.
Background and aims: Atherosclerotic plaque rupture is largely acknowledged as the main mechanism of acute coronary syndrome. However, the prognostic significance of plaque rupture detected in nonculprit coronary sites re...
Multicenter Study
Atherosclerosis. 2026 Jun:417:120681. DOI:10.1016/j.atherosclerosis.2026.120681 2026
Systematic evaluation of mobile element insertions in autosomal dominant hypercholesterolemia genes using short-read sequencing [0.03%]
利用短读测序系统评估载脂蛋白B和低密度脂蛋白受体基因中移动元件插入的状况
Lisa Jeanpetit,Corentin Molitor,Alexandre Janin et al.
Lisa Jeanpetit et al.
Background and aims: Autosomal dominant hypercholesterolemia (ADH) is a common monogenic disorder conferring markedly increased cardiovascular risk. While short-read next-generation sequencing (NGS) efficiently detects sm...
Persistent gaps in management and risk factor control among patients with atherosclerotic cardiovascular disease: All of us research program [0.03%]
动脉粥样硬化性心血管病患者的管理和危险因素控制存差距：All Of Us研究计划数据的启示
Yakubu Bene-Alhasan,Soad Al Osta,Yussif Issaka et al.
Yakubu Bene-Alhasan et al.
Background: Contemporary guidelines recommend aggressive low-density lipoprotein cholesterol (LDL-C) lowering in patients with atherosclerotic cardiovascular disease (ASCVD), yet significant treatment gaps persist in clin...
Context-dependent regulation of endothelial inflammation and atherosclerosis by endothelial microRNA-33 [0.03%]
内皮微小核糖核酸-33在内皮炎症和动脉粥样硬化中的调控作用
Kathryn M Citrin,Yan Huang,Alex Ramos-Perez et al.
Kathryn M Citrin et al.
Background and aims: Atherosclerosis arises through the metabolic and inflammatory perturbation of numerous cells, including immune cells and endothelial cells (ECs). microRNA-33 (miR-33) regulates lipid metabolism and in...
Pyoderma gangrenosum is associated with excess incident major atherothrombotic events [0.03%]
皮肤感染性皮肤病与额外的主要动脉粥样血栓事件相关
Hatim Kerniss,Henning Olbrich,Philip Curman et al.
Hatim Kerniss et al.
Background and aims: Systemic inflammation contributes to atherosclerosis and its thrombotic complications, yet population-level data for neutrophil-predominant dermatoses are limited. Pyoderma gangrenosum (PG) is a proto...
CD146 extracellular vesicles accumulate at atherosclerotic lesions, reducing inflammation and atheroma burden [0.03%]
CD146胞外囊泡在动脉粥样硬化部位富集并减少炎症和动脉粥样斑块负荷
Cléa Dubrou,Muriel G Blin,Karim Fallague et al.
Cléa Dubrou et al.
Atherosclerosis remains the most important cause of death worldwide despite an extensive therapeutic arsenal. We previously showed that CD146, an adhesion molecule expressed by endothelial cells, is harbored by macrophages in atheroscleroti...