Inflammasome inhibition in myocardial infarction reduces early reperfusion injury and suppresses systemic plaque activation [0.03%]
心肌梗死中凋亡相关硫酸盐氧化酶样受体抑制减少了再灌注损伤并抑制全身斑块活化
Santosh Karnewar,The Anh Nguyen,Koya Ozawa et al.
Santosh Karnewar et al.
Background and aims: Activation of innate immunity early after reperfused myocardial infarction (MI) contributes to reperfusion injury and acts systemically to accelerate atherosclerosis in remote non-culprit plaques. We ...
Genome-wide cross-trait analysis reveals immunogenetic pleiotropy between autoimmune diseases and myocardial infarction and prioritizes therapeutic targets [0.03%]
全基因组交叉性状分析揭示自身免疫疾病和心肌梗死之间的免疫遗传多效性并优先确定治疗靶点
Chung-Chih Liao,Wu-Chen Hu,Shun-Fa Yang et al.
Chung-Chih Liao et al.
Background and aims: Autoimmune diseases (ADs) are associated with increased myocardial infarction (MI) risk, suggesting shared genetic susceptibility. We systematically investigated the shared genetic architecture, pleio...
Distribution of Lipoprotein(a) concentrations in children and young people with Familial Hypercholesterolemia (FH) compared to those without FH: A systematic review and narrative synthesis [0.03%]
儿童和年轻人中家族性高胆固醇血症（FH）与非FH患者的Lp（a）浓度分布差异：系统评价和叙述性综述
Lorraine Priestley-Barnham,Steve E Humphries,Jo Wray et al.
Lorraine Priestley-Barnham et al.
Background: Elevated Lipoprotein(a) [Lp(a)] is an established independent risk factor for Atherosclerotic Cardiovascular Disease (ASCVD) in adults, largely determined by genetic variation and present from birth. Despite i...
G6PD inhibition prevents abdominal aortic aneurysm formation in mice induced by Ang II plus high salt [0.03%]
G6PD抑制可防止血管紧张素II和高盐诱导的小鼠腹主动脉瘤形成
Zhihui Wang,Yang Shi,Dou Shi et al.
Zhihui Wang et al.
Background and aims: Aortic aneurysms (AAs) are life-threatening conditions characterized by pathological dilation of the aorta and disruption of vascular structural integrity. Glucose-6-phosphate dehydrogenase (G6PD), th...
Quantitative PET coronary flow capacity and comprehensive management of chronic CAD: Lessons from the randomized CENTURY trial [0.03%]
定量正电子发射断层成像冠状动脉血流储备分数和慢性冠心病综合管理：CENTURY随机对照试验的启示
K Lance Gould,Nils P Johson
K Lance Gould
Background and aims: Randomized trials in chronic coronary artery disease (CAD) tested single interventions of lifestyle, medical treatment, or revascularization. The randomized CENTURY trial tested a comprehensive strate...
Global prevalence of elevated high-sensitivity C-reactive protein in patients with atherosclerotic cardiovascular disease, with and without chronic kidney disease: findings from the POSEIDON study [0.03%]
来自POSEIDON研究的成果：慢性肾脏疾病患者和非慢性肾脏疾病患者的动脉粥样硬化性心血管病患者高敏C反应蛋白升高的全球患病率
Ann Marie Navar,Ling Bai,Jesper Falkesgaard Højen et al.
Ann Marie Navar et al.
Background and aims: Inflammation is a causal risk factor for atherosclerotic cardiovascular disease (ASCVD). Contemporary global data on the prevalence of high inflammatory risk (high-sensitivity C-reactive protein [hsCR...
Methodological and clinical considerations in a Japanese cohort study of familial hypercholesterolemia and stroke-authors' reply [0.03%]
日本家族性高胆固醇血症和卒中队列研究的方法学和临床注意事项-作者回复
Yorito Hattori,Yuriko Nakaoku,Soshiro Ogata et al.
Yorito Hattori et al.
Optimized flow cytometry assay for functional characterization of variants of uncertain significance in familial hypercholesterolemia [0.03%]
用于家族性高胆固醇血症不确定意义变异的功能表征的优化流式细胞仪检测方法
Stella Covino,Alessia Di Costanzo,Alessandra Rossi et al.
Stella Covino et al.
Background: The definitive diagnosis of Familial Hypercholesterolemia (FH) relies on the identification of deleterious variants in FH-related genes, but many detected variants are classified as of uncertain significance (...
Causal insights of modifiable cardiovascular risk factors for dementia risk - potential for efficient prevention and improved brain health [0.03%]
痴呆风险的可改变心血管危险因素的因果关系见解-有效预防和改善脑健康的潜力
Jiao Luo,Ida Juul Rasmussen,Jesper Qvist Thomassen et al.
Jiao Luo et al.
Background: The 2024 Lancet Commission report identifies 14 modifiable risk factors that may prevent half of dementia. The causal nature of these associations remains however unclear. We aimed to establish robust causal e...
Serial OCT-based coronary physiology and plaque composition in vessels with nonobstructive coronary lesions following intensive lipid-lowering therapy: YELLOW III sub-study [0.03%]
一次性血管内光学相干断层扫描评估强化降脂治疗后非阻塞性冠状动脉病变的生理功能及斑块特征：YELL0WⅢ分支研究
Pruthvi C Revaiah,Yuliya Vengrenyuk,Vemuri Krishna Santosh et al.
Pruthvi C Revaiah et al.
Background and aims: Non-obstructive coronary plaques are a major source of future coronary events, particularly when characterized by high lipid burden and adverse plaque morphology. While intensive lipid-lowering therap...