Integrative multi-omics analysis identifies a mitochondrial dysfunction-associated diagnostic signature, molecular subtypes, and drug repurposing candidates for keloid disease [0.03%]
整合多组学分析识别与线粒体功能障碍相关的诊断标志物、分子亚型和老药新用候选药物以治疗瘢痕疙瘩疾病
Xin Le,Youfen Fan,Sida Xu et al.
Xin Le et al.
Background: Keloid, a fibroproliferative disorder, has limited treatments and lacks reliable biomarkers. Mitochondrial dysfunction is implicated in fibrosis, but its transcriptomic role in keloid remains incompletely char...
The Teen-Aged Life Impact Burn Recovery Evaluation profile: Item pool development for a computer adaptive test [0.03%]
青少年烧伤恢复生命质量评价量表：计算机自适应测试题库的建立
Madeleine B McGwin,Khushbu F Patel,Kate E Surette et al.
Madeleine B McGwin et al.
Introduction: Teenagers undergo significant developmental and social changes, which can be further complicated by burn injuries. A condition-specific patient-reported outcome measure is needed to assess the unique challen...
Artificial intelligence for outcome prediction in burn care: A scoping review [0.03%]
烧伤护理结果预测的人工智能研究：系统综述
JeeHwan Ahn,Jinseo Ahn,Jonathan Herron
JeeHwan Ahn
Introduction: Machine learning (ML) is increasingly applied across burn care, but its clinical utility remains unclear. This scoping review mapped current evidence on ML models developed to predict key outcomes in burn pa...
Skin grafting and regeneration: Bridging biological barriers towards functional regeneration [0.03%]
皮肤移植与再生：克服生物屏障实现功能再生
Jian-Kang Zhang,Zhi-Jin Zhang,Fang-Ting Shi et al.
Jian-Kang Zhang et al.
Despite being the clinical gold standard of care for severe skin defects, autologous grafting is constrained by limited donor resources, associated morbidity, and incomplete functional recovery. These challenges have catalyzed a transition ...
Experience-based co-design of paediatric burn service guidance to support parent-administered home dressing changes [0.03%]
基于经验的协同设计儿童烧伤服务指南以支持家长在家进行换药护理
Samantha Goodliffe,Clare Thomas,Jonathan Mathers et al.
Samantha Goodliffe et al.
Background: Annually over 30,000 children require outpatient treatment for burn accidents. Attending clinic appointments has a negative psychological and social impact on families. Many burns centres offer families the op...
Delayed inflammatory resolution and TGF-beta expressing Tregs are associated with healing outcomes in paediatric burns [0.03%]
延迟的炎症反应和TGF-β表达Tregs与儿童烧伤愈合结局相关性研究
Donna Langley,Andrew J A Holland,Giorgio Stefanutti et al.
Donna Langley et al.
The aim of this study was to identify immune cells and inflammatory mediators associated with delayed wound healing in paediatric burn patients. Peripheral blood mononuclear cells (PBMCs) were isolated from 30 paediatric participants: 10 he...
Carboxymethyl chitosan-based multifunctional hydrogel loaded with ginseng stem cell exosomes promotes severe burn wound healing through anti-inflammatory activity [0.03%]
基于壳聚糖的多功能水凝胶负载人参茎叶干细胞外泌体通过抗炎作用促进重度烧伤创面修复
Ran Ding,Yongming Wang,Zhiqing Long et al.
Ran Ding et al.
Severe burns cause excessive inflammation and immune dysregulation that delay healing and increase infection risk. Here, we developed an injectable self-healing hydrogel (CMCS/OHA/Exo, "Exo-gel") incorporating ginseng callus stem-cell-deriv...
Identification and validation of mitotic catastrophe-associated biomarkers for keloid [0.03%]
用于瘢痕疙瘩的有丝分裂灾难相关生物标志物的识别与验证
Hui Sun,Fei Yan,Zhen Kong et al.
Hui Sun et al.
Purpose: Exploring the role of mitotic catastrophe-related genes (MCRGs) in the development of keloid, a benign skin disorder. Methods: ...
Cryopreserved human amnion in pediatric burn care: A retrospective single-center study over a decade [0.03%]
十年来冷冻脱细胞人羊膜在儿童烧伤护理中的应用：单中心回顾性研究
Alfio Luca Costa,Luca Folini,Daniele Brunelli et al.
Alfio Luca Costa et al.
Background: Pediatric partial-thickness burns at function-critical sites require rapid epithelialization to limit hypertrophic scarring and contracture. We assessed outcomes after tangential dermabrasion with application ...