Insight into pathologic abnormalities in congenital semilunar valve disease based on advances in understanding normal valve microstructure and extracellular matrix [0.03%]
基于对正常瓣膜微结构和细胞外基质理解的进步探讨先天性半月形瓣膜疾病的病理异常
Elizabeth H Stephens,Debra L Kearney,K Jane Grande-Allen
Elizabeth H Stephens
Congenitally diseased valves are relatively frequent causes of significant morbidity and mortality. Pathology descriptions of such valves have primarily focused on gross structural features including the number of leaflets or commissures (b...
Reduced serum content and increased matrix stiffness promote the cardiac myofibroblast transition in 3D collagen matrices [0.03%]
降血清含量和增加矩阵刚度可促进三维胶原基质中心脏肌成纤维细胞的转变
Peter A Galie,Margaret V Westfall,Jan P Stegemann
Peter A Galie
Introduction: The fibroblast-myofibroblast transition is an important event in the development of cardiac fibrosis and scar formation initiated after myocardial ischemia. The goals of the present study were to better unde...
Proteinase inhibitor 9 is reduced in human atherosclerotic lesion development [0.03%]
人类动脉粥样硬化病变中蛋白质酶抑素9降低
Alon Hendel,Dawn Cooper,Thomas Abraham et al.
Alon Hendel et al.
Background: Granzyme B, a proapoptotic serine protease, is abundant in advanced, unstable atherosclerotic plaques, and it is suggested to contribute to plaque instability by inducing vascular smooth muscle cells apoptosis...
Mechanical function, glycolysis, and ultrastructure of perfused working mouse hearts following thoracic aortic constriction [0.03%]
胸主动脉缩窄后灌注小鼠心脏的机械功能、糖酵解和超微结构的研究
Michael E Dunn,Thomas G Manfredi,Arthur C Cosmas et al.
Michael E Dunn et al.
Background: Glycolytic flux in the mouse heart during the progression of left ventricular hypertrophy (LVH) and mechanical dysfunction has not been described. ...
Giant cell aortitis: a difficult diagnosis assessing risk for the development of aneurysms and dissections [0.03%]
巨细胞主动脉炎：一种难以诊断的疾病，评估其发展成动脉瘤和夹层的风险
Andrew Lee,Adriana Luk,Katharine R B Phillips et al.
Andrew Lee et al.
A significant location affected by giant cell (GC) arteritis is the ascending aorta, where aneurysms may develop and catastrophic ruptures and acute dissections can occur. Herein, we discuss three cases of GC aortitis discovered at patholog...
Insulin-like growth factor-1 overexpression in cardiomyocytes diminishes ex vivo heart functional recovery after acute ischemia [0.03%]
胰岛素样生长因子-1在心肌细胞中的过度表达可降低急性缺血后离体心脏功能恢复能力
Cecilia M Prêle,Melissa E Reichelt,Steven E Mutsaers et al.
Cecilia M Prêle et al.
Background: Acute insulin-like growth factor-1 administration has been shown to have beneficial effects in cardiac pathological conditions. The aim of the present study was to assess the structural and ex vivo functional ...
Bicuspid aortic valve disease: the role of oxidative stress in Lrp5 bone formation [0.03%]
双叶主动脉瓣疾病：Lrp5骨形成的氧化应激作用
Nalini M Rajamannan
Nalini M Rajamannan
The bicuspid aortic valve is a common congenital cardiac anomaly, having a prevalence of 0.9% to 1.37% in the general population and a male preponderance ratio of 2:1. The recognition of a bicuspid aortic valve is clinically relevant becaus...
Incidental finding of cor triatriatum sinister in an adult post-myocardial infarction [0.03%]
心肌梗塞成人患者偶然发现左心房三腔畸形综合征(cor triatriatum sinister)
Adriana Luk,Andrew Lee,Katharine R B Phillips et al.
Adriana Luk et al.
We report a case of a 51-year-old man who was transferred from a community hospital to our institution in cardiogenic shock after thrombolytic therapy for myocardial infarction. At autopsy, a cor triatriatum sinister was found. This may hav...
The aortic valve microenvironment and its role in calcific aortic valve disease [0.03%]
主动脉瓣微环境及其在主动脉瓣钙化病中的作用
Cindy Ying Yin Yip,Craig A Simmons
Cindy Ying Yin Yip
In calcific aortic valve disease, fibrotic and calcific lesions form focally in the fibrosa layer of the valve leaflets. Layer-specific pathosusceptibility suggests that the fibrosa microenvironment is permissive to pathological development...
Differential proteoglycan and hyaluronan distribution in calcified aortic valves [0.03%]
软化主动脉瓣中蛋白多糖和透明质酸的分布差异分析
Elizabeth H Stephens,Jerome G Saltarrelli,L Scott Baggett et al.
Elizabeth H Stephens et al.
Background: While the prevalence of calcified aortic valve disease continues to rise and no pharmacological treatments exist, little is known regarding the pathogenesis of the disease. Proteoglycans and the glycosaminogly...