Comparative study of four matrix effect correction strategies for bile acid quantification in mouse serum [0.03%]
四种矩阵效应校正策略在小鼠血清胆汁酸定量中的比较研究
Mengjun Xie,Xin Guo,Shilin Shen et al.
Mengjun Xie et al.
Endogenous substances are components produced by metabolism within the body, and they play a crucial role in disease diagnosis, treatment, and the regulation of physiological functions. However, it is difficult to obtain a blank matrix or s...
Vitamin D in major depressive disorder: Current evidence, possible molecular mechanisms, and future prospects [0.03%]
维生素D与重度抑郁障碍：现有证据、可能的分子机制及未来前景
Anderson Camargo,Ana Lúcia S Rodrigues
Anderson Camargo
Vitamin D signaling has emerged as a significant modulator of neurobiological processes implicated in major depressive disorder (MDD). Beyond its classical functions in calcium homeostasis and bone health, accumulating evidence highlights a...
A DEQAS review of the current performance of assays for the measurement of 1,25dihydroxyvitamin D [0.03%]
一项关于1,25-二羟维生素D测定检测性能的DEQAS评审
Georgia E Hackney,Emma L Williams
Georgia E Hackney
The Vitamin D External Quality Assessment Scheme (DEQAS) evaluates participants' performance of analytical methods for vitamin D metabolites, including 1,25dihydroxyvitamin D (1,25(OH)2D), by distributing samples globally on a quarterly bas...
Vitamin D as a multisystem regulatory hormone: Molecular pathways, physiological integration, and implications for physical performance [0.03%]
维生素D作为一种多系统调节激素：分子途径、生理整合以及对身体机能表现的影响
Anuroopa G Nadh,Aswin Mohan,Harshit Sajal et al.
Anuroopa G Nadh et al.
Vitamin D is a pleiotropic secosteroid hormone whose biological actions extend far beyond calcium- phosphate homeostasis. Emerging experimental evidence highlights the regulatory role of this vitamin across multiple organ systems and signal...
Knowledge, attitudes and practices related to vitamin D in young adults in rural Sri Lankan settings [0.03%]
斯里兰卡农村地区年轻人关于维生素D的知识、态度和行为调查研究
Thilanka Ranathunga,Himasha Wickramasinghe
Thilanka Ranathunga
Vitamin D is a fat-soluble vitamin that can be synthesized in the skin upon sunlight exposure. Proper Knowledge, Attitudes, and Practices (KAP) related to vitamin D are essential to achieve optimum vitamin D status in the community. Therefo...
Molly J Mead,S Taylor Woollen,Mathew J Gregoski et al.
Molly J Mead et al.
Introduction: Human milk oligosaccharides (HMOs) arise from tightly regulated glycosylation pathways and exert pleiotropic effects on infant immune, microbial, and neurodevelopmental trajectories. Vitamin D influences gen...
Hydration and interfacial behavior of 7-ketocholesterol monolayers: A comparative molecular dynamics study with cholesterol using the OPC water model [0.03%]
7-酮胆固醇单层的溶剂化和界面行为：使用OPC水模型与胆固醇进行比较分子动力学研究
Jan Kobierski,Anita Wnętrzak,Anna Chachaj-Brekiesz et al.
Jan Kobierski et al.
We investigate how oxidation of cholesterol at the C7 position alters sterol hydration and interfacial organization by combining Langmuir monolayer experiments with all-atom molecular dynamics simulations employing the OPC water model. Whil...
Vitamin D deficiency selectively exacerbates mitochondrial dysfunction in receptor-rich soleus muscle during disuse-induced atrophy [0.03%]
维生素D缺乏选择性地加剧了在失用性萎缩期间富含受体的比目肌线粒体功能障碍
Moe Matsumoto,Natsumi Yanagisawa,Kaoruko Iida
Moe Matsumoto
This study investigated the role of vitamin D (VD) in disuse skeletal muscle atrophy, with a particular focus on muscle type-specific differences. Male C57BL/6 J mice were fed either a standard or VD-deficient diet and subjected to hindlimb...
Sexual dimorphism in liver fibrotic metabolic dysfunction: Effects of testosterone and estrogen on CCl4-induced liver injury in ovariectomy and orchiectomy models [0.03%]
四氯化碳诱导的去势小鼠肝纤维化代谢障碍及性激素调节作用研究
Zi Yi Chen,Mogellah John Panga,Xueting Wang et al.
Zi Yi Chen et al.
Liver fibrosis is closely linked to metabolic dysfunction and hormonal regulation, with sex differences influencing disease progression. This study combined untargeted liver metabolomic profiling with ovariectomy and orchiectomy mouse model...
Targeting 7-ketocholesterol-driven metabolic dysfunction in obesity: Therapeutic potential of Bifidobacterium and dietary antioxidants [0.03%]
靶向肥胖引起的7-酮胆固醇驱动的代谢紊乱：双歧杆菌和膳食抗氧化剂的治疗潜力
Arin Natania S
Arin Natania S
7-Ketocholesterol (7-KC), a highly cytotoxic oxysterol generated during cholesterol oxidation, accumulates in obesity-associated dyslipidemia and plays a significant role in sustaining chronic low-grade inflammation, oxidative stress, and a...