Transcriptomic profiling of oocyte maturation in allotetraploid hybrid fish and identification of HSD17b12 mediating DHP synthesis [0.03%]
四倍体杂交鱼卵母细胞成熟的转录组分析及鉴定介导DHP合成的HSD17B12基因
Shujia Liao,Donglan Diao,Yonglin Miao et al.
Shujia Liao et al.
To reveal the molecular regulatory mechanism underlying oocyte development and maturation in an allotetraploid hybrid of Pengze crucian carp (♀) × Xingguo red carp (♂), the oocyte growth stage (PG, PV, EV, MV, LV and FG) and maturation s...
Jyoti,Gurpreet Singh,Mamta Bishnoi et al.
Jyoti et al.
Organ transplantation has evolved significantly since the first successful kidney transplant in the 1950s, but corticosteroids remain a mainstay of immunosuppressive therapy. This review addresses the emerging and expanding role of corticos...
Importance of oxysterols in nutrition, cancer and other degenerative diseases [0.03%]
氧化固醇在营养、癌症和其他退行性疾病中的重要性
Marc Poirot,Philippe de Médina,Sandrine Silvente-Poirot
Marc Poirot
Acetoacetyl-CoA synthetase modulates lipid partitioning and cholesterol-related gene expression in NEFA-challenged neonatal bovine hepatocytes [0.03%]
乙酰辅酶a合成酶调节NEFA刺激的新生牛肝细胞中的脂质分布和胆固醇相关基因表达
Yan Tian,Shuang Wang,Juan J Loor et al.
Yan Tian et al.
Ketosis is a common metabolic disorder in dairy cows, typically occurring during early postpartum negative energy balance and characterized by hyperketonemia, hepatic lipid accumulation, and oxidative stress. Although acetoacetyl-CoA synthe...
Progesterone and Estrogen Signaling in Uterine Fibroids: A tale of two interconnected pathways [0.03%]
子宫肌瘤中的孕酮和雌激素信号：两个相互关联的通路的故事
Kavita,Shikha Singh,Neha Garg
Kavita
Uterine fibroids are monoclonal tumors occurring in females of reproductive age. The etiology of UFs is still not completely known, but they arise from a single mutation in smooth muscle cells of the uterus. These are hormone-dependent tumo...
Dehydroepiandrosterone alleviates pulmonary fibrosis by modulating the TLR4/NF-κB/NLRP3 signaling cascade in macrophages [0.03%]
脱氢表雄酮通过调节巨噬细胞中的TLR4 / NF-κB / NLRP3信号级联反应来缓解肺纤维化
Qingqing Xie,Xu Zhao,Yiwei Lu et al.
Qingqing Xie et al.
Idiopathic pulmonary fibrosis (IPF) is a severe progressive lung disease with limited treatment options. Dehydroepiandrosterone (DHEA), an endogenous steroid hormone, possesses anti-inflammatory and anti-fibrotic properties, but its mechani...
Detection of Activin A and Follistatin as Potential Biomarkers in Women with Ovarian Endometriosis [0.03%]
检测抗苗勒管激素、活化素A和抗活化素A抗体 follistatin在女性卵巢子宫内膜异位症患者中的潜在生物标志物作用
Nahlah F Makki,Sawsan H Kadhum
Nahlah F Makki
Endometriosis is a condition characterized by the growth of tissue similar to the uterine lining outside the uterus. This study aimed to evaluate certain sex hormones and determine the levels of activin A and follistatin in women with endom...
Novel 5α-reductase inhibitors unlinked to depression-like phenotypes in rat model of BPH [0.03%]
新型未表现出抑郁表型的5α-还原酶抑制剂治疗BPH_rat模型相关研究
Bhawna Khanna,Priyanka Rana,Akash Saini et al.
Bhawna Khanna et al.
Finasteride clinically approved for the treatment of benign prostatic hyperplasia exerts its therapeutic effect by inhibiting type II 5α-reductase, thereby reducing dihydrotestosterone levels, leading to prostate shrinkage and symptomatic ...
Age-specific centiles for fibroblast growth factor 23 and its associations with mineral and bone metabolism in healthy children [0.03%]
健康儿童的纤维细胞生长因子23年龄别百分位数及其与矿质和骨代谢的关系
Isabelle Piec,Andre Chu,Ben Nichols et al.
Isabelle Piec et al.
Background: Fibroblast Growth Factor 23 (FGF23) regulates phosphate and vitamin D metabolism and is implicated in pediatric disorders such as X-linked hypophosphatemia and CKD-mineral and bone disorder. Accurate interpret...
Chronic Mifepristone Administration Induces Obese Sarcopenia, Hepatic Steatosis and Insulin Resistance in Androgen-Deprived Male Mice [0.03%]
长期米非司酮给药可诱导去势雄性小鼠发生肥胖 sarcopenia、肝脂肪变性和胰岛素抵抗
Jiameng Shang,Keyu Yan,Lulu Liu et al.
Jiameng Shang et al.
Both glucocorticoids receptor (GR) and peroxisome proliferator-activated receptor-γ (PPARγ) are critical metabolic checkpoints in endocrine control of whole-body energy homeostasis. Mifepristone, which serves as a non-selective antagonist...