Testosterone increases clonogenicity and self-renewal capacity of human glioblastoma cells [0.03%]
睾酮通过表观遗传调控方式增加人脑胶质母细胞瘤干细胞特性的体外克隆形成能力和体内自我更新能力
Juan Carlos Quintero,Omar Rafael Alemán,Laura Noemi Hernández-Lúa et al.
Juan Carlos Quintero et al.
Glioblastoma is the most common and aggressive malignant brain tumor in adults, characterized by rapid progression and limited therapeutic response. The presence of glioma stem cells contributes to high recurrence and treatment resistance. ...
Role of 5α-reductase inhibitors in Parkinson's disease: Gambling or not? [0.03%]
5α-还原酶抑制剂在帕金森病中的作用：赌博还是突破？
Nawar Raad Hussein,Hayder M Al-Kuraishy,Esraa H Fahad et al.
Nawar Raad Hussein et al.
Parkinson's disease (PD) is a progressive neurodegenerative disease due to degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc). The fundamental cause of PD is not completely confirmed. However, genetic, epigene...
Evolutionary Divergence and Expression Dynamics of the Progestin Receptor System: Sex-Specific Responses to Exogenous Progestin in Spinibarbus hollandi [0.03%]
孕激素受体系统的进化分化及其表达动态：厚唇鱼适应外源性孕激素的性别特异性响应机制研究
Jiangwei Zhou,Weicheng Yang,Wenwei Huang et al.
Jiangwei Zhou et al.
Progestin signaling in teleosts is mediated by a diverse receptor repertoire that has been further expanded after genome duplication. However, how these receptors are organized and respond to exogenous stimulation within a single species re...
miR-148a-3p is elevated in serum of PCOS women and modulates ALDH1A3-retinoic acid signaling to reduce estrogen synthesis in granulosa-like cells [0.03%]
miR-148a-3p在PCOS女性血清中升高并通过调节ALDH1A3-视黄酸信号通路减少颗粒细胞如雌激素合成
Emre Murat Altinkilic,Kay Sara Sauter,Therina du Toit et al.
Emre Murat Altinkilic et al.
Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder with substantial reproductive and metabolic consequences, yet its molecular mechanisms remain incompletely understood. This study investigated circulating microRNAs (miR...
Ameliorative effects and mechanisms of Inonotus hispidus on PCOS via regulation of gut microbiota-ovarian metabolism axis and ferroptosis inhibition [0.03%]
刺毛壳菌通过调节肠道微生物群-卵巢代谢轴和抑制铁死亡改善多囊卵巢综合征的作用及机制研究
Jingjing Zhao,Die Hu,Haiying Bao et al.
Jingjing Zhao et al.
Polycystic ovary syndrome (PCOS) is a prevalent endocrine metabolic disorder with limited therapeutic options. This study investigated the ameliorative effects and underlying mechanisms of the water extract of Inonotus hispidus (WE) on PCOS...
Characterization of a novel synthetic constitutive-active glucocorticoid receptor [0.03%]
新型合成组成性激活型糖皮质激素受体的特征分析
Hong Lu,Conor Fahy,Guirong Wang
Hong Lu
Glucocorticoids (GCs), acting via the glucocorticoid receptor (GR), are the only available drugs for severe alcoholic hepatitis (AH). Additionally, GCs are important drugs for various lung diseases. However, GCs lack long-term benefits and ...
A nuclear delivery strategy for curative treatment of COPD using 1α,25-dihydroxyvitamin D3 and lipid nanoparticles [0.03%]
一种用于COPD治愈性治疗的1α,25-二羟基维生素D3和脂质纳米颗粒核递送策略
Tomomi Akita,Wakana Nemoto,Takehiro Kawai et al.
Tomomi Akita et al.
Chronic obstructive pulmonary disease (COPD) presents with obstructive ventilation disorders. Because no drugs can regenerate destroyed alveoli, there is an urgent need for new treatments that repair alveolar damage. We previously reported ...
Antiplatelet activity of novel aminoestrogens: R-β-mefenetame as a candidate for safer estrogen-based therapies [0.03%]
新型氨基雌激素的抗血小板活性：R-β-美芬氨酯作为更安全的雌激素疗法候选药物
Esbeidy García-Flores,Benny Giovanni Cazarín-Santos,Simón Hernández-Ortega et al.
Esbeidy García-Flores et al.
Hormone replacement therapy (HRT) relieves menopausal symptoms and improves quality of life. Also, estrogen-based regimens are needed for feminizing gender-affirming hormone therapy (GAHT). However, estrogen therapies may evoke thrombotic c...
Photoperiodic regulation of genes involved in steroidogenesis in adult tree sparrows (Passer montanus) [0.03%]
树麻雀成年个体中参与类固醇生成的基因的光周期调节
Subu Yatung,Lalmuanpuia Ralte,Amit Kumar Trivedi
Subu Yatung
Light serves as the primary environmental cue for timing life-history stages in a seasonal breeder. This study examines the effects of photoperiod, intensity, and spectrum on reproductive processes, particularly steroidogenesis, in adult tr...
The Co-occurrence of Iron and vitamin D deficiency in the middle east: A regional review with a focus on Saudi Arabia as a case study for integrated public health strategies [0.03%]
中东铁和维生素D缺乏并存的现状：以沙特阿拉伯为例的区域综述及公共卫生策略整合研究重点
Khaled Essawi
Khaled Essawi
Iron deficiency (ID) and vitamin D deficiency (VDD) often occur together in Saudi Arabia and across the Middle East, influenced by shared cultural, dietary, and environmental factors. This narrative review compiles evidence on this dual iss...